Efficient synthesis of polymethoxyselenoflavones via regioselective direct C-H arylation of selenochromones

Woo Ram Yang, Yong Sung Choi, Jin Hyun Jeong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Substantial research has suggested that the configuration and the total number of functional groups on flavones influence their bioactivity. To investigate the changes in the biological activities of selenoflavones in relationship to structural changes, the development of a generally applicable synthetic method was a key. Until now, an efficient pathway for palladium-catalyzed direct arylation with the selenocyclic enone systems is not known in the literature. We herein introduce a simple direct C-H arylation of two difficult coupling partners, selenochromones and electron-rich aryl bromide, affording diverse polymethoxyselenoflavones with great efficiency and high selectivity.

Original languageEnglish
Pages (from-to)3074-3083
Number of pages10
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number14
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Flavones
Palladium
activity (biology)
Bioactivity
Bromides
palladium
bromides
selectivity
Electrons
synthesis
configurations
Research
Functional groups
electrons

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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abstract = "Substantial research has suggested that the configuration and the total number of functional groups on flavones influence their bioactivity. To investigate the changes in the biological activities of selenoflavones in relationship to structural changes, the development of a generally applicable synthetic method was a key. Until now, an efficient pathway for palladium-catalyzed direct arylation with the selenocyclic enone systems is not known in the literature. We herein introduce a simple direct C-H arylation of two difficult coupling partners, selenochromones and electron-rich aryl bromide, affording diverse polymethoxyselenoflavones with great efficiency and high selectivity.",
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Efficient synthesis of polymethoxyselenoflavones via regioselective direct C-H arylation of selenochromones. / Yang, Woo Ram; Choi, Yong Sung; Jeong, Jin Hyun.

In: Organic and Biomolecular Chemistry, Vol. 15, No. 14, 01.01.2017, p. 3074-3083.

Research output: Contribution to journalArticle

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