EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro

Minsu Jang; Rackhyun Park; Yea In Park; Yeo Eun Cha; Ayane Yamamoto; Jin I. Lee; Junsoo Park

doi:10.1016/j.bbrc.2021.02.016

EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro

Minsu Jang, Rackhyun Park, Yea In Park, Yeo Eun Cha, Ayane Yamamoto, Jin I. Lee, Junsoo Park

Division of Bioscience and Biotechnology

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication.

Original language	English
Pages (from-to)	23-28
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	547
DOIs	https://doi.org/10.1016/j.bbrc.2021.02.016
Publication status	Published - 2021 Apr 2

Bibliographical note

Funding Information:
This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government ( 2019R1A2C1006511 ).

Publisher Copyright:
© 2021 Elsevier Inc.

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2021.02.016

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title = "EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro",

abstract = "COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication.",

author = "Minsu Jang and Rackhyun Park and Park, {Yea In} and Cha, {Yeo Eun} and Ayane Yamamoto and Lee, {Jin I.} and Junsoo Park",

note = "Funding Information: This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government ( 2019R1A2C1006511 ). Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

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doi = "10.1016/j.bbrc.2021.02.016",

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T1 - EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro

AU - Jang, Minsu

AU - Park, Rackhyun

AU - Park, Yea In

AU - Cha, Yeo Eun

AU - Yamamoto, Ayane

AU - Lee, Jin I.

AU - Park, Junsoo

N1 - Funding Information: This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government ( 2019R1A2C1006511 ). Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021/4/2

Y1 - 2021/4/2

N2 - COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication.

AB - COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication.

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EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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