EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro

Minsu Jang, Rackhyun Park, Yea In Park, Yeo Eun Cha, Ayane Yamamoto, Jin I. Lee, Junsoo Park

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalBiochemical and Biophysical Research Communications
Publication statusPublished - 2021 Apr 2

Bibliographical note

Funding Information:
This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government ( 2019R1A2C1006511 ).

Publisher Copyright:
© 2021 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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