Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test

Chang Soo Chon, Hui Suk Yun, Han Sung Kim, Cheolwoong Ko

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A biomechanical test is a good evaluation method that describes the structural, functional, and pathological differences in the bones, such as osteoporosis and fracture. The tensile test, compression test, and bending test are generally performed to evaluate the elastic modulus of the bone using mice. In particular, the femoral head compression test is mainly used for verifying the osteoporosis change of the femoral neck. This study conducted bone mineral density analysis using in vivo microcomputed tomography (micro-CT) to observe changes in osteoporosis over time. It proposed a method of identifying the elastic modulus of the femur in the normal group (CON group) and the osteoporotic group (OVX group) through finite element analysis based on the femoral head compression test and also conducted a comparative analysis of the results. Through the femoral head compression test, it was verified that the CON group's ultimate and yield loads were significantly higher than those of the OVX group. It was considered that this result was caused by the fact that the bone mineral density change by osteoporosis occurred in the proximal end more often than in the femur diaphysis. However, the elastic modulus derived from the finite element analysis showed no significant difference between the two groups.

Original languageEnglish
Article number7201769
JournalApplied Bionics and Biomechanics
Volume2017
DOIs
Publication statusPublished - 2017

Bibliographical note

Funding Information:
The authors gratefully acknowledge Mr. Taemin BYUN for his sincere help on computational simulations and data analysis. This study was supported by grants from Korea Institute of Industrial Technology and by the National Research Council of Science and Technology (NST) grant by the Korean Government (MSIP) (no. CAP-15-09-KIMS).

Publisher Copyright:
© 2017 Chang-soo Chon et al.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine (miscellaneous)
  • Bioengineering
  • Biomedical Engineering

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