Elasticizing tissues for reversible shape transformation and accelerated molecular labeling

Taeyun Ku; Webster Guan; Nicholas B. Evans; Chang Ho Sohn; Alexandre Albanese; Joon Goon Kim; Matthew P. Frosch; Kwanghun Chung

doi:10.1038/s41592-020-0823-y

Elasticizing tissues for reversible shape transformation and accelerated molecular labeling

Taeyun Ku, Webster Guan, Nicholas B. Evans, Chang Ho Sohn, Alexandre Albanese, Joon Goon Kim, Matthew P. Frosch, Kwanghun Chung

Yonsei Advanced Science Institute

Research output: Contribution to journal › Article

Abstract

We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.

Original language	English
Pages (from-to)	609-613
Number of pages	5
Journal	Nature Methods
Volume	17
Issue number	6
DOIs	https://doi.org/10.1038/s41592-020-0823-y
Publication status	Published - 2020 Jun 1

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Molecular Biology
Cell Biology

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Ku, T., Guan, W., Evans, N. B., Sohn, C. H., Albanese, A., Kim, J. G., Frosch, M. P., & Chung, K. (2020). Elasticizing tissues for reversible shape transformation and accelerated molecular labeling. Nature Methods, 17(6), 609-613. https://doi.org/10.1038/s41592-020-0823-y

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