Elastin content of the renal pelvis and ureter determines post-pyeloplasty recovery

Suk Kim Dong, Yeun Noh Ji, Joo Jeong Hyeon, Joon Kim Myung, Jin Jeon Hyung, Sangwon Han

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: We evaluated the collagen-to-smooth muscle tissue matrix ratio and percentage of elastin in the renal pelvis, ureteropelvic junction (UPJ) and ureter, and compared these findings with the degree of obstruction, patient age and post-pyeloplasty renal recovery. Materials and Methods: We analyzed histological sections from 75 patients with UPJ obstruction. Nine patients were excluded owing to bilateral UPJ obstruction and an improper specimen. We divided the specimen obtained from pyeloplasty into 3 parts, namely the renal pelvis above the obstruction, the obstructed UPJ portion and the ureter below the obstruction. To examine the collagen and smooth muscle, sections were stained using Masson's trichrome, and elastic van Giesson stain was used for elastin, smooth muscle and collagen. Collagen, smooth muscle and elastin populations were identified, and the tissue matrix ratio and percentage of elastin were calculated by color image analysis. Results: In patients with lower ratios of collagen-to-smooth muscle in the UPJ proper hydronephrosis was more improved postoperatively (p = 0.049). In patients with a lower percentage of elastin in the renal pelvis, UPJ and ureter hydronephrosis was more improved postoperatively (p <0.0001). Conclusions: Because the UPJ portion was resected during pyeloplasty, the renal pelvis and the ureter remaining after pyeloplasty are likely to be related to improved hydronephrosis. A higher percentage of elastin in the renal pelvis and ureter contributes to inelasticity and low compliance, and results in a slower recovery from hydronephrosis after pyeloplasty.

Original languageEnglish
Pages (from-to)962-966
Number of pages5
JournalJournal of Urology
Volume173
Issue number3
DOIs
Publication statusPublished - 2005 Jan 1

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Kidney Pelvis
Elastin
Ureter
Hydronephrosis
Smooth Muscle
Collagen
Compliance
Coloring Agents
Color
Kidney
Muscles
Population

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Dong, Suk Kim ; Ji, Yeun Noh ; Hyeon, Joo Jeong ; Myung, Joon Kim ; Hyung, Jin Jeon ; Han, Sangwon. / Elastin content of the renal pelvis and ureter determines post-pyeloplasty recovery. In: Journal of Urology. 2005 ; Vol. 173, No. 3. pp. 962-966.
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Elastin content of the renal pelvis and ureter determines post-pyeloplasty recovery. / Dong, Suk Kim; Ji, Yeun Noh; Hyeon, Joo Jeong; Myung, Joon Kim; Hyung, Jin Jeon; Han, Sangwon.

In: Journal of Urology, Vol. 173, No. 3, 01.01.2005, p. 962-966.

Research output: Contribution to journalArticle

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T1 - Elastin content of the renal pelvis and ureter determines post-pyeloplasty recovery

AU - Dong, Suk Kim

AU - Ji, Yeun Noh

AU - Hyeon, Joo Jeong

AU - Myung, Joon Kim

AU - Hyung, Jin Jeon

AU - Han, Sangwon

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N2 - Purpose: We evaluated the collagen-to-smooth muscle tissue matrix ratio and percentage of elastin in the renal pelvis, ureteropelvic junction (UPJ) and ureter, and compared these findings with the degree of obstruction, patient age and post-pyeloplasty renal recovery. Materials and Methods: We analyzed histological sections from 75 patients with UPJ obstruction. Nine patients were excluded owing to bilateral UPJ obstruction and an improper specimen. We divided the specimen obtained from pyeloplasty into 3 parts, namely the renal pelvis above the obstruction, the obstructed UPJ portion and the ureter below the obstruction. To examine the collagen and smooth muscle, sections were stained using Masson's trichrome, and elastic van Giesson stain was used for elastin, smooth muscle and collagen. Collagen, smooth muscle and elastin populations were identified, and the tissue matrix ratio and percentage of elastin were calculated by color image analysis. Results: In patients with lower ratios of collagen-to-smooth muscle in the UPJ proper hydronephrosis was more improved postoperatively (p = 0.049). In patients with a lower percentage of elastin in the renal pelvis, UPJ and ureter hydronephrosis was more improved postoperatively (p <0.0001). Conclusions: Because the UPJ portion was resected during pyeloplasty, the renal pelvis and the ureter remaining after pyeloplasty are likely to be related to improved hydronephrosis. A higher percentage of elastin in the renal pelvis and ureter contributes to inelasticity and low compliance, and results in a slower recovery from hydronephrosis after pyeloplasty.

AB - Purpose: We evaluated the collagen-to-smooth muscle tissue matrix ratio and percentage of elastin in the renal pelvis, ureteropelvic junction (UPJ) and ureter, and compared these findings with the degree of obstruction, patient age and post-pyeloplasty renal recovery. Materials and Methods: We analyzed histological sections from 75 patients with UPJ obstruction. Nine patients were excluded owing to bilateral UPJ obstruction and an improper specimen. We divided the specimen obtained from pyeloplasty into 3 parts, namely the renal pelvis above the obstruction, the obstructed UPJ portion and the ureter below the obstruction. To examine the collagen and smooth muscle, sections were stained using Masson's trichrome, and elastic van Giesson stain was used for elastin, smooth muscle and collagen. Collagen, smooth muscle and elastin populations were identified, and the tissue matrix ratio and percentage of elastin were calculated by color image analysis. Results: In patients with lower ratios of collagen-to-smooth muscle in the UPJ proper hydronephrosis was more improved postoperatively (p = 0.049). In patients with a lower percentage of elastin in the renal pelvis, UPJ and ureter hydronephrosis was more improved postoperatively (p <0.0001). Conclusions: Because the UPJ portion was resected during pyeloplasty, the renal pelvis and the ureter remaining after pyeloplasty are likely to be related to improved hydronephrosis. A higher percentage of elastin in the renal pelvis and ureter contributes to inelasticity and low compliance, and results in a slower recovery from hydronephrosis after pyeloplasty.

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