Electroanatomic remodeling of the left stellate ganglion after myocardial infarction

Seongwook Han, Kenzaburo Kobayashi, Boyoung Joung, Gianfranco Piccirillo, Mitsunori Maruyama, Harry V. Vinters, Keith March, Shien Fong Lin, Changyu Shen, Michael C. Fishbein, Peng Sheng Chen, Lan S. Chen

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Abstract

Objectives: The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI). Background: Whether MI results in remodeling of extracardiac nerve activity remains unclear. Methods: We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram in 9 ambulatory dogs. After baseline monitoring, MI was created by 1-h balloon occlusion of the coronary arteries. The dogs were then continuously monitored for 2 months. Both stellate ganglia were stained for growth-associated protein 43 and synaptophysin. The stellate ganglia from 5 normal dogs were used as control. Results: MI increased 24-h integrated SGNA from 7.44 ± 7.19 Ln(Vs)/day at baseline to 8.09 ± 7.75 Ln(Vs)/day after the MI (p < 0.05). The 24-h integrated VNA before and after the MI was 5.29 ± 5.04 Ln(Vs)/day and 5.58 ± 5.15 Ln(Vs)/day, respectively (p < 0.05). A significant 24-h circadian variation was noted for the SGNA (p < 0.05) but not the VNA. The SGNA/VNA ratio also showed significant circadian variation. The nerve densities from the left SG were 63,218 ± 34,719 μm 2/mm 2 and 20,623 ± 4,926 μm 2/mm 2 for growth-associated protein 43 (p < 0.05) and were 32,116 ± 8,190 μm 2/mm 2and 16,326 ± 4,679 μm 2/mm 2 for synaptophysin (p < 0.05) in MI and control groups, respectively. The right SG also showed increased nerve density after MI (p < 0.05). Conclusions: MI results in persistent increase in the synaptic density of bilateral stellate ganglia and is associated with increased SGNA and VNA. There is a circadian variation of the SGNA/VNA ratio. These data indicate significant remodeling of the extracardiac autonomic nerve activity and structures after MI.

Original languageEnglish
Pages (from-to)954-961
Number of pages8
JournalJournal of the American College of Cardiology
Volume59
Issue number10
DOIs
Publication statusPublished - 2012 Mar 6

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Stellate Ganglion
Myocardial Infarction
GAP-43 Protein
Synaptophysin
Dogs
Thoracic Nerves
Balloon Occlusion
Autonomic Pathways
Coronary Vessels
Electrocardiography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Han, Seongwook ; Kobayashi, Kenzaburo ; Joung, Boyoung ; Piccirillo, Gianfranco ; Maruyama, Mitsunori ; Vinters, Harry V. ; March, Keith ; Lin, Shien Fong ; Shen, Changyu ; Fishbein, Michael C. ; Chen, Peng Sheng ; Chen, Lan S. / Electroanatomic remodeling of the left stellate ganglion after myocardial infarction. In: Journal of the American College of Cardiology. 2012 ; Vol. 59, No. 10. pp. 954-961.
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title = "Electroanatomic remodeling of the left stellate ganglion after myocardial infarction",
abstract = "Objectives: The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI). Background: Whether MI results in remodeling of extracardiac nerve activity remains unclear. Methods: We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram in 9 ambulatory dogs. After baseline monitoring, MI was created by 1-h balloon occlusion of the coronary arteries. The dogs were then continuously monitored for 2 months. Both stellate ganglia were stained for growth-associated protein 43 and synaptophysin. The stellate ganglia from 5 normal dogs were used as control. Results: MI increased 24-h integrated SGNA from 7.44 ± 7.19 Ln(Vs)/day at baseline to 8.09 ± 7.75 Ln(Vs)/day after the MI (p < 0.05). The 24-h integrated VNA before and after the MI was 5.29 ± 5.04 Ln(Vs)/day and 5.58 ± 5.15 Ln(Vs)/day, respectively (p < 0.05). A significant 24-h circadian variation was noted for the SGNA (p < 0.05) but not the VNA. The SGNA/VNA ratio also showed significant circadian variation. The nerve densities from the left SG were 63,218 ± 34,719 μm 2/mm 2 and 20,623 ± 4,926 μm 2/mm 2 for growth-associated protein 43 (p < 0.05) and were 32,116 ± 8,190 μm 2/mm 2and 16,326 ± 4,679 μm 2/mm 2 for synaptophysin (p < 0.05) in MI and control groups, respectively. The right SG also showed increased nerve density after MI (p < 0.05). Conclusions: MI results in persistent increase in the synaptic density of bilateral stellate ganglia and is associated with increased SGNA and VNA. There is a circadian variation of the SGNA/VNA ratio. These data indicate significant remodeling of the extracardiac autonomic nerve activity and structures after MI.",
author = "Seongwook Han and Kenzaburo Kobayashi and Boyoung Joung and Gianfranco Piccirillo and Mitsunori Maruyama and Vinters, {Harry V.} and Keith March and Lin, {Shien Fong} and Changyu Shen and Fishbein, {Michael C.} and Chen, {Peng Sheng} and Chen, {Lan S.}",
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Han, S, Kobayashi, K, Joung, B, Piccirillo, G, Maruyama, M, Vinters, HV, March, K, Lin, SF, Shen, C, Fishbein, MC, Chen, PS & Chen, LS 2012, 'Electroanatomic remodeling of the left stellate ganglion after myocardial infarction', Journal of the American College of Cardiology, vol. 59, no. 10, pp. 954-961. https://doi.org/10.1016/j.jacc.2011.11.030

Electroanatomic remodeling of the left stellate ganglion after myocardial infarction. / Han, Seongwook; Kobayashi, Kenzaburo; Joung, Boyoung; Piccirillo, Gianfranco; Maruyama, Mitsunori; Vinters, Harry V.; March, Keith; Lin, Shien Fong; Shen, Changyu; Fishbein, Michael C.; Chen, Peng Sheng; Chen, Lan S.

In: Journal of the American College of Cardiology, Vol. 59, No. 10, 06.03.2012, p. 954-961.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Electroanatomic remodeling of the left stellate ganglion after myocardial infarction

AU - Han, Seongwook

AU - Kobayashi, Kenzaburo

AU - Joung, Boyoung

AU - Piccirillo, Gianfranco

AU - Maruyama, Mitsunori

AU - Vinters, Harry V.

AU - March, Keith

AU - Lin, Shien Fong

AU - Shen, Changyu

AU - Fishbein, Michael C.

AU - Chen, Peng Sheng

AU - Chen, Lan S.

PY - 2012/3/6

Y1 - 2012/3/6

N2 - Objectives: The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI). Background: Whether MI results in remodeling of extracardiac nerve activity remains unclear. Methods: We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram in 9 ambulatory dogs. After baseline monitoring, MI was created by 1-h balloon occlusion of the coronary arteries. The dogs were then continuously monitored for 2 months. Both stellate ganglia were stained for growth-associated protein 43 and synaptophysin. The stellate ganglia from 5 normal dogs were used as control. Results: MI increased 24-h integrated SGNA from 7.44 ± 7.19 Ln(Vs)/day at baseline to 8.09 ± 7.75 Ln(Vs)/day after the MI (p < 0.05). The 24-h integrated VNA before and after the MI was 5.29 ± 5.04 Ln(Vs)/day and 5.58 ± 5.15 Ln(Vs)/day, respectively (p < 0.05). A significant 24-h circadian variation was noted for the SGNA (p < 0.05) but not the VNA. The SGNA/VNA ratio also showed significant circadian variation. The nerve densities from the left SG were 63,218 ± 34,719 μm 2/mm 2 and 20,623 ± 4,926 μm 2/mm 2 for growth-associated protein 43 (p < 0.05) and were 32,116 ± 8,190 μm 2/mm 2and 16,326 ± 4,679 μm 2/mm 2 for synaptophysin (p < 0.05) in MI and control groups, respectively. The right SG also showed increased nerve density after MI (p < 0.05). Conclusions: MI results in persistent increase in the synaptic density of bilateral stellate ganglia and is associated with increased SGNA and VNA. There is a circadian variation of the SGNA/VNA ratio. These data indicate significant remodeling of the extracardiac autonomic nerve activity and structures after MI.

AB - Objectives: The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI). Background: Whether MI results in remodeling of extracardiac nerve activity remains unclear. Methods: We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram in 9 ambulatory dogs. After baseline monitoring, MI was created by 1-h balloon occlusion of the coronary arteries. The dogs were then continuously monitored for 2 months. Both stellate ganglia were stained for growth-associated protein 43 and synaptophysin. The stellate ganglia from 5 normal dogs were used as control. Results: MI increased 24-h integrated SGNA from 7.44 ± 7.19 Ln(Vs)/day at baseline to 8.09 ± 7.75 Ln(Vs)/day after the MI (p < 0.05). The 24-h integrated VNA before and after the MI was 5.29 ± 5.04 Ln(Vs)/day and 5.58 ± 5.15 Ln(Vs)/day, respectively (p < 0.05). A significant 24-h circadian variation was noted for the SGNA (p < 0.05) but not the VNA. The SGNA/VNA ratio also showed significant circadian variation. The nerve densities from the left SG were 63,218 ± 34,719 μm 2/mm 2 and 20,623 ± 4,926 μm 2/mm 2 for growth-associated protein 43 (p < 0.05) and were 32,116 ± 8,190 μm 2/mm 2and 16,326 ± 4,679 μm 2/mm 2 for synaptophysin (p < 0.05) in MI and control groups, respectively. The right SG also showed increased nerve density after MI (p < 0.05). Conclusions: MI results in persistent increase in the synaptic density of bilateral stellate ganglia and is associated with increased SGNA and VNA. There is a circadian variation of the SGNA/VNA ratio. These data indicate significant remodeling of the extracardiac autonomic nerve activity and structures after MI.

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