Abstract
Objectives: The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI). Background: Whether MI results in remodeling of extracardiac nerve activity remains unclear. Methods: We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram in 9 ambulatory dogs. After baseline monitoring, MI was created by 1-h balloon occlusion of the coronary arteries. The dogs were then continuously monitored for 2 months. Both stellate ganglia were stained for growth-associated protein 43 and synaptophysin. The stellate ganglia from 5 normal dogs were used as control. Results: MI increased 24-h integrated SGNA from 7.44 ± 7.19 Ln(Vs)/day at baseline to 8.09 ± 7.75 Ln(Vs)/day after the MI (p < 0.05). The 24-h integrated VNA before and after the MI was 5.29 ± 5.04 Ln(Vs)/day and 5.58 ± 5.15 Ln(Vs)/day, respectively (p < 0.05). A significant 24-h circadian variation was noted for the SGNA (p < 0.05) but not the VNA. The SGNA/VNA ratio also showed significant circadian variation. The nerve densities from the left SG were 63,218 ± 34,719 μm 2/mm 2 and 20,623 ± 4,926 μm 2/mm 2 for growth-associated protein 43 (p < 0.05) and were 32,116 ± 8,190 μm 2/mm 2and 16,326 ± 4,679 μm 2/mm 2 for synaptophysin (p < 0.05) in MI and control groups, respectively. The right SG also showed increased nerve density after MI (p < 0.05). Conclusions: MI results in persistent increase in the synaptic density of bilateral stellate ganglia and is associated with increased SGNA and VNA. There is a circadian variation of the SGNA/VNA ratio. These data indicate significant remodeling of the extracardiac autonomic nerve activity and structures after MI.
| Original language | English |
|---|---|
| Pages (from-to) | 954-961 |
| Number of pages | 8 |
| Journal | Journal of the American College of Cardiology |
| Volume | 59 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2012 Mar 6 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
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Electroanatomic remodeling of the left stellate ganglion after myocardial infarction. / Han, Seongwook; Kobayashi, Kenzaburo; Joung, Boyoung; Piccirillo, Gianfranco; Maruyama, Mitsunori; Vinters, Harry V.; March, Keith; Lin, Shien Fong; Shen, Changyu; Fishbein, Michael C.; Chen, Peng Sheng; Chen, Lan S.
In: Journal of the American College of Cardiology, Vol. 59, No. 10, 06.03.2012, p. 954-961.Research output: Contribution to journal › Article
TY - JOUR
T1 - Electroanatomic remodeling of the left stellate ganglion after myocardial infarction
AU - Han, Seongwook
AU - Kobayashi, Kenzaburo
AU - Joung, Boyoung
AU - Piccirillo, Gianfranco
AU - Maruyama, Mitsunori
AU - Vinters, Harry V.
AU - March, Keith
AU - Lin, Shien Fong
AU - Shen, Changyu
AU - Fishbein, Michael C.
AU - Chen, Peng Sheng
AU - Chen, Lan S.
PY - 2012/3/6
Y1 - 2012/3/6
N2 - Objectives: The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI). Background: Whether MI results in remodeling of extracardiac nerve activity remains unclear. Methods: We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram in 9 ambulatory dogs. After baseline monitoring, MI was created by 1-h balloon occlusion of the coronary arteries. The dogs were then continuously monitored for 2 months. Both stellate ganglia were stained for growth-associated protein 43 and synaptophysin. The stellate ganglia from 5 normal dogs were used as control. Results: MI increased 24-h integrated SGNA from 7.44 ± 7.19 Ln(Vs)/day at baseline to 8.09 ± 7.75 Ln(Vs)/day after the MI (p < 0.05). The 24-h integrated VNA before and after the MI was 5.29 ± 5.04 Ln(Vs)/day and 5.58 ± 5.15 Ln(Vs)/day, respectively (p < 0.05). A significant 24-h circadian variation was noted for the SGNA (p < 0.05) but not the VNA. The SGNA/VNA ratio also showed significant circadian variation. The nerve densities from the left SG were 63,218 ± 34,719 μm 2/mm 2 and 20,623 ± 4,926 μm 2/mm 2 for growth-associated protein 43 (p < 0.05) and were 32,116 ± 8,190 μm 2/mm 2and 16,326 ± 4,679 μm 2/mm 2 for synaptophysin (p < 0.05) in MI and control groups, respectively. The right SG also showed increased nerve density after MI (p < 0.05). Conclusions: MI results in persistent increase in the synaptic density of bilateral stellate ganglia and is associated with increased SGNA and VNA. There is a circadian variation of the SGNA/VNA ratio. These data indicate significant remodeling of the extracardiac autonomic nerve activity and structures after MI.
AB - Objectives: The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI). Background: Whether MI results in remodeling of extracardiac nerve activity remains unclear. Methods: We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram in 9 ambulatory dogs. After baseline monitoring, MI was created by 1-h balloon occlusion of the coronary arteries. The dogs were then continuously monitored for 2 months. Both stellate ganglia were stained for growth-associated protein 43 and synaptophysin. The stellate ganglia from 5 normal dogs were used as control. Results: MI increased 24-h integrated SGNA from 7.44 ± 7.19 Ln(Vs)/day at baseline to 8.09 ± 7.75 Ln(Vs)/day after the MI (p < 0.05). The 24-h integrated VNA before and after the MI was 5.29 ± 5.04 Ln(Vs)/day and 5.58 ± 5.15 Ln(Vs)/day, respectively (p < 0.05). A significant 24-h circadian variation was noted for the SGNA (p < 0.05) but not the VNA. The SGNA/VNA ratio also showed significant circadian variation. The nerve densities from the left SG were 63,218 ± 34,719 μm 2/mm 2 and 20,623 ± 4,926 μm 2/mm 2 for growth-associated protein 43 (p < 0.05) and were 32,116 ± 8,190 μm 2/mm 2and 16,326 ± 4,679 μm 2/mm 2 for synaptophysin (p < 0.05) in MI and control groups, respectively. The right SG also showed increased nerve density after MI (p < 0.05). Conclusions: MI results in persistent increase in the synaptic density of bilateral stellate ganglia and is associated with increased SGNA and VNA. There is a circadian variation of the SGNA/VNA ratio. These data indicate significant remodeling of the extracardiac autonomic nerve activity and structures after MI.
UR - http://www.scopus.com/inward/record.url?scp=84863230112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863230112&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2011.11.030
DO - 10.1016/j.jacc.2011.11.030
M3 - Article
C2 - 22381432
AN - SCOPUS:84863230112
VL - 59
SP - 954
EP - 961
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 10
ER -