Electrochemical deposition of dopamine-hyaluronic acid conjugates for anti-biofouling bioelectrodes

Semin Kim, Yohan Jang, Lindy K. Jang, Sung Hyuk Sunwoo, Tae Il Kim, Seung-Woo Cho, Jae Young Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Bioelectrodes have been widely used to effectively mediate electrical signals with biological systems for various biomedical applications, such as biosensors and prosthetic probes. However, the electrical properties of bioelectrodes are frequently degraded in the biological milieu due to biofouling of bioelectrode surfaces. Hence, the development of simple and effective strategies for bioelectrode surface modification is important for the mitigation of biofouling. To this end, we electrochemically modify electrodes with dopamine-conjugated hyaluronic acid (DA-HA); the modified electrodes exhibit highly hydrophilic surfaces. In addition, the electrochemical impedance of the DA-HA-modified electrodes remains similar to those of bare electrodes. The DA-HA-modified electrodes showed reduced non-specific protein adsorption and minimal adhesion of fibroblasts. Our novel electrochemical passivation of electrodes using DA-HA will contribute to the further development of fouling-resistant and biocompatible bioelectrodes. The electrodeposition of DA-HA can also be potentially applied for general surface modification of other metallic and conducting materials for various applications.

Original languageEnglish
Pages (from-to)4507-4513
Number of pages7
JournalJournal of Materials Chemistry B
Volume5
Issue number23
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Biofouling
Hyaluronic acid
Hyaluronic Acid
Dopamine
Electrodes
Surface treatment
Biological systems
Fibroblasts
Fouling
Prosthetics
Passivation
Biosensors
Electrodeposition
Electric properties
Adhesion
Proteins
Adsorption

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

Kim, Semin ; Jang, Yohan ; Jang, Lindy K. ; Sunwoo, Sung Hyuk ; Kim, Tae Il ; Cho, Seung-Woo ; Lee, Jae Young. / Electrochemical deposition of dopamine-hyaluronic acid conjugates for anti-biofouling bioelectrodes. In: Journal of Materials Chemistry B. 2017 ; Vol. 5, No. 23. pp. 4507-4513.
@article{77188f7a9bf34ec4a5392a8121803080,
title = "Electrochemical deposition of dopamine-hyaluronic acid conjugates for anti-biofouling bioelectrodes",
abstract = "Bioelectrodes have been widely used to effectively mediate electrical signals with biological systems for various biomedical applications, such as biosensors and prosthetic probes. However, the electrical properties of bioelectrodes are frequently degraded in the biological milieu due to biofouling of bioelectrode surfaces. Hence, the development of simple and effective strategies for bioelectrode surface modification is important for the mitigation of biofouling. To this end, we electrochemically modify electrodes with dopamine-conjugated hyaluronic acid (DA-HA); the modified electrodes exhibit highly hydrophilic surfaces. In addition, the electrochemical impedance of the DA-HA-modified electrodes remains similar to those of bare electrodes. The DA-HA-modified electrodes showed reduced non-specific protein adsorption and minimal adhesion of fibroblasts. Our novel electrochemical passivation of electrodes using DA-HA will contribute to the further development of fouling-resistant and biocompatible bioelectrodes. The electrodeposition of DA-HA can also be potentially applied for general surface modification of other metallic and conducting materials for various applications.",
author = "Semin Kim and Yohan Jang and Jang, {Lindy K.} and Sunwoo, {Sung Hyuk} and Kim, {Tae Il} and Seung-Woo Cho and Lee, {Jae Young}",
year = "2017",
month = "1",
day = "1",
doi = "10.1039/c7tb00028f",
language = "English",
volume = "5",
pages = "4507--4513",
journal = "Journal of Materials Chemistry B",
issn = "2050-7518",
publisher = "Royal Society of Chemistry",
number = "23",

}

Electrochemical deposition of dopamine-hyaluronic acid conjugates for anti-biofouling bioelectrodes. / Kim, Semin; Jang, Yohan; Jang, Lindy K.; Sunwoo, Sung Hyuk; Kim, Tae Il; Cho, Seung-Woo; Lee, Jae Young.

In: Journal of Materials Chemistry B, Vol. 5, No. 23, 01.01.2017, p. 4507-4513.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Electrochemical deposition of dopamine-hyaluronic acid conjugates for anti-biofouling bioelectrodes

AU - Kim, Semin

AU - Jang, Yohan

AU - Jang, Lindy K.

AU - Sunwoo, Sung Hyuk

AU - Kim, Tae Il

AU - Cho, Seung-Woo

AU - Lee, Jae Young

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Bioelectrodes have been widely used to effectively mediate electrical signals with biological systems for various biomedical applications, such as biosensors and prosthetic probes. However, the electrical properties of bioelectrodes are frequently degraded in the biological milieu due to biofouling of bioelectrode surfaces. Hence, the development of simple and effective strategies for bioelectrode surface modification is important for the mitigation of biofouling. To this end, we electrochemically modify electrodes with dopamine-conjugated hyaluronic acid (DA-HA); the modified electrodes exhibit highly hydrophilic surfaces. In addition, the electrochemical impedance of the DA-HA-modified electrodes remains similar to those of bare electrodes. The DA-HA-modified electrodes showed reduced non-specific protein adsorption and minimal adhesion of fibroblasts. Our novel electrochemical passivation of electrodes using DA-HA will contribute to the further development of fouling-resistant and biocompatible bioelectrodes. The electrodeposition of DA-HA can also be potentially applied for general surface modification of other metallic and conducting materials for various applications.

AB - Bioelectrodes have been widely used to effectively mediate electrical signals with biological systems for various biomedical applications, such as biosensors and prosthetic probes. However, the electrical properties of bioelectrodes are frequently degraded in the biological milieu due to biofouling of bioelectrode surfaces. Hence, the development of simple and effective strategies for bioelectrode surface modification is important for the mitigation of biofouling. To this end, we electrochemically modify electrodes with dopamine-conjugated hyaluronic acid (DA-HA); the modified electrodes exhibit highly hydrophilic surfaces. In addition, the electrochemical impedance of the DA-HA-modified electrodes remains similar to those of bare electrodes. The DA-HA-modified electrodes showed reduced non-specific protein adsorption and minimal adhesion of fibroblasts. Our novel electrochemical passivation of electrodes using DA-HA will contribute to the further development of fouling-resistant and biocompatible bioelectrodes. The electrodeposition of DA-HA can also be potentially applied for general surface modification of other metallic and conducting materials for various applications.

UR - http://www.scopus.com/inward/record.url?scp=85021658226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021658226&partnerID=8YFLogxK

U2 - 10.1039/c7tb00028f

DO - 10.1039/c7tb00028f

M3 - Article

VL - 5

SP - 4507

EP - 4513

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

SN - 2050-7518

IS - 23

ER -