TY - JOUR
T1 - Electrochemical tuning of oxygen-containing groups on graphene oxides
T2 - Towards control of the performance for the analysis of biomarkers
AU - Lim, Chee Shan
AU - Ambrosi, Adriano
AU - Pumera, Martin
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/6/28
Y1 - 2014/6/28
N2 - Graphene materials are very popular in the field of biosensing owing to their distinctive characteristics. However, oxygen-containing groups are known to exist intrinsically in graphene-related materials. These groups influence the electrochemical properties of graphene materials and therefore affect the sensing performance of graphene-based electrodes when used to detect redox active biomarkers. A well-defined carbon/oxygen (C/O) ratio can be obtained upon applying different reduction potentials to graphene oxide (GO) films for a controlled removal of redox active oxygen functionalities. Here, we show that a precise control of the oxygen functionalities on the graphene oxide films allows the tuning of the biosensing capabilities of the electrodes for the analysis of two significant biomarkers, uric acid and ascorbic acid, as well as two DNA bases, guanine and adenine. Both the catalytic properties and the sensitivity of the reduced GO film electrodes (ERGOs) are evaluated by measuring the oxidation potential and the peak current, respectively. We demonstrate that each biomarker requires different optimal conditions which can be easily matched by varying the electrochemical pre-treatment of the sensing GO film.
AB - Graphene materials are very popular in the field of biosensing owing to their distinctive characteristics. However, oxygen-containing groups are known to exist intrinsically in graphene-related materials. These groups influence the electrochemical properties of graphene materials and therefore affect the sensing performance of graphene-based electrodes when used to detect redox active biomarkers. A well-defined carbon/oxygen (C/O) ratio can be obtained upon applying different reduction potentials to graphene oxide (GO) films for a controlled removal of redox active oxygen functionalities. Here, we show that a precise control of the oxygen functionalities on the graphene oxide films allows the tuning of the biosensing capabilities of the electrodes for the analysis of two significant biomarkers, uric acid and ascorbic acid, as well as two DNA bases, guanine and adenine. Both the catalytic properties and the sensitivity of the reduced GO film electrodes (ERGOs) are evaluated by measuring the oxidation potential and the peak current, respectively. We demonstrate that each biomarker requires different optimal conditions which can be easily matched by varying the electrochemical pre-treatment of the sensing GO film.
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U2 - 10.1039/c4cp01558d
DO - 10.1039/c4cp01558d
M3 - Article
C2 - 24817612
AN - SCOPUS:84901779475
VL - 16
SP - 12178
EP - 12182
JO - Physical Chemistry Chemical Physics
JF - Physical Chemistry Chemical Physics
SN - 1463-9076
IS - 24
ER -