Electrogenic transport and K + ion channel expression by the human endolymphatic sac epithelium

Sung Huhn Kim, Bo Gyung Kim, Jin Young Kim, Kyung Jin Roh, Michelle J. Suh, Jinsei Jung, InSeok Moon, Sung K. Moon, Jae Young Choi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The endolymphatic sac (ES) is a cystic organ that is a part of the inner ear and is connected to the cochlea and vestibule. The ES is thought to be involved in inner ear ion homeostasis and fluid volume regulation for the maintenance of hearing and balance function. Many ion channels, transporters, and exchangers have been identified in the ES luminal epithelium, mainly in animal studies, but there has been no functional study investigating ion transport using human ES tissue. We designed the first functional experiments on electrogenic transport in human ES and investigated the contribution of K + channels in the electrogenic transport, which has been rarely identified, even in animal studies, using electrophysiological/pharmacological and molecular biological methods. As a result, we identified functional and molecular evidence for the essential participation of K + channels in the electrogenic transport of human ES epithelium. The identified K + channels involved in the electrogenic transport were KCNN2, KCNJ14, KCNK2, and KCNK6, and the K + transports via those channels are thought to play an important role in the maintenance of the unique ionic milieu of the inner ear fluid.

Original languageEnglish
Article number18110
JournalScientific reports
Volume5
DOIs
Publication statusPublished - 2015 Dec 14

Fingerprint

Endolymphatic Sac
Ion Channels
Epithelium
Inner Ear
Maintenance
Cochlea
Ion Transport
Hearing
Homeostasis
Pharmacology
Ions

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kim, S. H., Kim, B. G., Kim, J. Y., Roh, K. J., Suh, M. J., Jung, J., ... Choi, J. Y. (2015). Electrogenic transport and K + ion channel expression by the human endolymphatic sac epithelium Scientific reports, 5, [18110]. https://doi.org/10.1038/srep18110
Kim, Sung Huhn ; Kim, Bo Gyung ; Kim, Jin Young ; Roh, Kyung Jin ; Suh, Michelle J. ; Jung, Jinsei ; Moon, InSeok ; Moon, Sung K. ; Choi, Jae Young. / Electrogenic transport and K + ion channel expression by the human endolymphatic sac epithelium In: Scientific reports. 2015 ; Vol. 5.
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Electrogenic transport and K + ion channel expression by the human endolymphatic sac epithelium . / Kim, Sung Huhn; Kim, Bo Gyung; Kim, Jin Young; Roh, Kyung Jin; Suh, Michelle J.; Jung, Jinsei; Moon, InSeok; Moon, Sung K.; Choi, Jae Young.

In: Scientific reports, Vol. 5, 18110, 14.12.2015.

Research output: Contribution to journalArticle

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AU - Jung, Jinsei

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