Electromechanical method coupling non-invasive skin impedance probing and in vivo subcutaneous liquid microinjection: Controlling the diffusion pattern of nanoparticles within living soft tissues

Baeckkyoung Sung, Se Hoon Kim, Jin Kyu Lee, Byung Cheon Lee, Kwang Sup Soh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Transdermal drug delivery is the way to transport drug carriers, such as nanoparticles, across the skin barrier to the dermal and/or subcutaneous layer. In order to control the transdermal drug delivery process, based on the heterogeneous and nonlinear structures of the skin tissues, we developed a novel electromechanical method combining in vivo local skin impedance probing, subcutaneous micro-injection of colloidal nanoparticles, and transcutaneous electrical stimulation. Experiments on the nude mice using in vivo fluorescence imaging exhibited significantly different apparent diffusion patterns of the nanoparticles depending on the skin impedance: Anisotropic and isotropic patterns were observed upon injection into low and high impedance points, respectively. This result implies that the physical complexity in living tissues may cause anisotropic diffusion of drug carriers, and can be used as a parameter for controlling drug delivery process. This method also can be combined with microneedle-based drug release systems, micro-fabricated needle-electrodes, and/or advanced in vivo targeting/imaging technologies using nanoparticles.

Original languageEnglish
Pages (from-to)645-653
Number of pages9
JournalBiomedical Microdevices
Volume16
Issue number4
DOIs
Publication statusPublished - 2014 Aug

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Molecular Biology

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