Electrophysiological rotor ablation in in-silico modeling of atrial fibrillation: Comparisons with dominant frequency, shannon entropy, and phase singularity

Minki Hwang, Jun Seop Song, Young Seon Lee, Changyong Li, Eun Bo Shim, Hui Nam Pak

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17 Citations (Scopus)

Abstract

Background: Although rotors have been considered among the drivers of atrial fibrillation (AF), the rotor definition is inconsistent. We evaluated the nature of rotors in 2D and 3D in- silico models of persistent AF (PeAF) by analyzing phase singularity (PS), dominant frequency (DF), Shannon entropy (ShEn), and complex fractionated atrial electrogram cycle length (CFAE-CL) and their ablation. Methods: Mother rotor was spatiotemporally defined as stationary reentries with a meandering tip remaining within half the wavelength and lasting longer than 5 s. We generated 2D- and 3D-maps of the PS, DF, ShEn, and CFAE-CL during AF. The spatial correlations and ablation outcomes targeting each parameter were analyzed. Results: 1. In the 2D PeAF model, we observed a mother rotor that matched relatively well with DF (>9 Hz, 71.0%, p<0.001), ShEn (upper 2.5%, 33.2%, p<0.001), and CFAE-CL (lower 2.5%, 23.7%, p<0.001). 2. The 3D-PeAF model also showed mother rotors that had spatial correlations with DF (>5.5 Hz, 39.7%, p<0.001), ShEn (upper 8.5%, 15.1%, p <0.001), and CFAE (lower 8.5%, 8.0%, p = 0.002). 3. In both the 2D and 3D models, virtual ablation targeting the upper 5% of the DF terminated AF within 20 s, but not the ablations based on long-lasting PS, high ShEn area, or lower CFAE-CL area. Conclusion: Mother rotors were observed in both 2D and 3D human AF models. Rotor locations were well represented by DF, and their virtual ablation altered wave dynamics and terminated AF.

Original languageEnglish
Article numbere0149695
JournalPloS one
Volume11
Issue number2
DOIs
Publication statusPublished - 2016 Feb

Bibliographical note

Funding Information:
This work was supported by the Korea Health 21 RandD Project, Ministry of Health and Welfare (https://www.htdream.kr/) [A085136 to HNP], the Basic Science Research Program run by the National Research Foundation of Korea (NRF) (http://www.nrf.re.kr/nrf-eng-cms/) which is funded by the Ministry of Science, ICT and Future Planning (MSIP) [NRF-2013R1A2A2A01014634 to HNP], and Basic Science Research Program through the National Research Foundation of Korea (NRF) (http://www.nrf.re.kr/nrf-eng-cms/) funded by the Ministry of Education [2014R1A1A2059391 to MH]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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