Electrophysiological significance of the interatrial conduction including cavo-tricuspid isthmus during atrial fibrillation

Byounghyun Lim, Je Wook Park, Minki Hwang, Ah Jin Ryu, In Soo Kim, Hee Tae Yu, Boyoung Joung, Eun Bo Shim, Hui Nam Pak

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Key points: The interatrial conduction, including Bachmann's bundle, the posterior septal conduction, the anterior septal conduction, and the cavo-tricuspid isthmus, contributes to the maintenance mechanisms of atrial fibrillation in a 3D biatrial model. The interatrial conduction ablation including a cavo-tricuspid isthmus ablation significantly affects the wave dynamics of atrial fibrillation (AF) and facilitates the AF termination or atrial tachycardia conversion of the AF after the circumferential pulmonary vein isolation. Additional cavo-tricuspid isthmus ablation after the circumferential pulmonary vein isolation improves long-term rhythm outcome after clinical AF catheter ablation. Abstract: Although it is known that atrial fibrillation (AF) is mainly a left atrial (LA) disease, the role of the right atrium (RA) and interatrial conduction (IAC), including the cavo-tricuspid isthmus (CTI), has not been clearly defined. We tested AF wave dynamics with or without IAC in computational modelling and the rhythm outcome of AF catheter ablation (AFCA) including CTI ablation in clinical cohort data. We evaluated the dominant frequency (DF) in 3D biatrial AF simulations integrated with 3D-computed tomograms obtained from 10 patients. The IAC was implemented at Bachmann's bundle, posterior septum and the CTI. After virtual circumferential PV isolation (CPVI), we disconnected IACs one by one, and observed the wave dynamics. We compared the long-term rhythm outcome after CPVI alone and additional CTI ablation in 846 patients with AFCA. LA-DF was higher than RA-DF in AF (P < 0.001). After CPVI, the DF decreased significantly by additional IAC ablation (P = 0.003), especially in the LA (P = 0.016). The amount of DF reduction (P = 0.020) and rates of AF termination (P < 0.001) or AT conversion (P = 0.021) were significantly higher after IAC ablations including CTI than those without. In clinical AFCA, the AF recurrence rate was significantly lower in patients with additional CTI ablation than CPVI alone during 25 ± 20 months’ follow-up (hazard ratio 0.60 [0.46–0.79], P < 0.001, Log rank P < 0.001). IAC contributes to the maintenance mechanism of AF, and IAC including CTI ablation affects AF wave dynamics, facilitating AF termination in 3D biatrial modelling. Additional CTI ablation after CPVI improves the long-term rhythm outcome in clinical AFCA, potentially in a paroxysmal type with accompanying atrial flutter, or atrial dimension close to normal.

Original languageEnglish
Pages (from-to)3597-3612
Number of pages16
JournalJournal of Physiology
Issue number17
Publication statusPublished - 2020 Sep 1

Bibliographical note

Funding Information:
This work was supported by grants HI18C0070 and HI19C0114 from the Ministry of Health and Welfare and grants NRF‐2020R1A2B01001695 and NRF‐2019R1C1C1009075 from the Basic Science Research Program run by the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science, ICT & Future Planning (MSIP).

Publisher Copyright:
© 2020 The Authors. The Journal of Physiology © 2020 The Physiological Society

All Science Journal Classification (ASJC) codes

  • Physiology


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