Electrospun nanofibers as versatile interfaces for efficient gene delivery

Slgirim Lee, Gyuhyung Jin, Jae Hyung Jang

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

The integration of gene delivery technologies with electrospun nanofibers is a versatile strategy to increase the potential of gene therapy as a key platform technology that can be readily utilized for numerous biomedical applications, including cancer therapy, stem cell therapy, and tissue engineering. As a spatial template for gene delivery, electrospun nanofibers possess highly advantageous characteristics, such as their ease of production, their ECM-analogue nature, the broad range of choices for materials, the feasibility of producing structures with varied physical and chemical properties, and their large surface-to-volume ratios. Thus, electrospun fiber-mediated gene delivery exhibits a great capacity to modulate the spatial and temporal release kinetics of gene vectors and enhance gene delivery efficiency. This review discusses the powerful characteristics of electrospun nanofibers, which can function as spatial interfaces capable of promoting controlled and efficient gene delivery.

Original languageEnglish
Article number30
JournalJournal of Biological Engineering
Volume8
Issue number1
DOIs
Publication statusPublished - 2014 Dec 9

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Biomedical Engineering
  • Molecular Biology
  • Cell Biology

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