The integration of gene delivery technologies with electrospun nanofibers is a versatile strategy to increase the potential of gene therapy as a key platform technology that can be readily utilized for numerous biomedical applications, including cancer therapy, stem cell therapy, and tissue engineering. As a spatial template for gene delivery, electrospun nanofibers possess highly advantageous characteristics, such as their ease of production, their ECM-analogue nature, the broad range of choices for materials, the feasibility of producing structures with varied physical and chemical properties, and their large surface-to-volume ratios. Thus, electrospun fiber-mediated gene delivery exhibits a great capacity to modulate the spatial and temporal release kinetics of gene vectors and enhance gene delivery efficiency. This review discusses the powerful characteristics of electrospun nanofibers, which can function as spatial interfaces capable of promoting controlled and efficient gene delivery.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant through the Active Polymer Center for Pattern Integration (NRF-2007-0056558), Basic Science Research Program (NRF-2012R1A1A1003397), and Bio & Medical Technology Development Program (NRF-2013M3A9D3046431) funded by the Ministry of Science, ICT & Future Planning (MSIP). This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C1564).
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All Science Journal Classification (ASJC) codes
- Environmental Engineering
- Biomedical Engineering
- Molecular Biology
- Cell Biology