Elevated cardiac troponin T predicts cardiovascular events in asymptomatic continuous ambulatory peritoneal dialysis patients without a history of cardiovascular disease

Seung Hyeok Han, Hoon Young Choi, Dong Ki Kim, Sung Jin Moon, Jung Eun Lee, Tae Hyun Yoo, Beom Seok Kim, Shin Wook Kang, Kyu Hun Choi, Ho Yung Lee, Dae Suk Han

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Recent studies revealed that elevated cardiac troponin T (cTnT) could predict all-cause mortality and cardiovascular diseases in end-stage renal disease patients. This study aimed to evaluate cTnT as a prognostic value in asymptomatic continuous ambulatory peritoneal dialysis patients. Methods: This is a prospective observational study with 107 prevalent peritoneal dialysis patients. cTnT, high-sensitive C-reactive protein (hsCRP) and IL-6 were measured at baseline. Based on cTnT level, patients were classified as higher cTnT group (HT, n = 21, cTnT ≥0.1 ng/ml) and lower cTnT group (LT, n = 86, cTnT <0.1 ng/ml), and were followed for 3 years. Primary endpoint was cardiovascular events. Results: The HT group had a significantly higher level of log hsCRP and log IL-6 than the LT group (p < 0.05). Kaplan-Meier survival demonstrated worse cardiovascular event-free survival for the HT group. Multivariate analysis adjusted for age, cTnT, IL-6 and hsCRP level revealed that age (per 1-year increase, HR 1.07, p < 0.05), elevated cTnT (vs. <0.1 ng/ml, HR 5.89, p < 0.05) and hsCRP (vs. <3.0 mg/l, HR 4.15, p < 0.05) were identified as significant determinants of cardiovascular events. Conclusion: This study suggests that cTnT may be an aid in risk stratification of continuous ambulatory peritoneal dialysis patients.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalAmerican Journal of Nephrology
Volume29
Issue number2
DOIs
Publication statusPublished - 2009 Jan 1

Fingerprint

Troponin T
Continuous Ambulatory Peritoneal Dialysis
Cardiovascular Diseases
C-Reactive Protein
Interleukin-6
Peritoneal Dialysis
Disease-Free Survival
Chronic Kidney Failure
Observational Studies
Multivariate Analysis
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Han, Seung Hyeok ; Choi, Hoon Young ; Kim, Dong Ki ; Moon, Sung Jin ; Lee, Jung Eun ; Yoo, Tae Hyun ; Kim, Beom Seok ; Kang, Shin Wook ; Choi, Kyu Hun ; Lee, Ho Yung ; Han, Dae Suk. / Elevated cardiac troponin T predicts cardiovascular events in asymptomatic continuous ambulatory peritoneal dialysis patients without a history of cardiovascular disease. In: American Journal of Nephrology. 2009 ; Vol. 29, No. 2. pp. 129-135.
@article{e646c439e46f4ce1acc884fe4ec6dd01,
title = "Elevated cardiac troponin T predicts cardiovascular events in asymptomatic continuous ambulatory peritoneal dialysis patients without a history of cardiovascular disease",
abstract = "Background: Recent studies revealed that elevated cardiac troponin T (cTnT) could predict all-cause mortality and cardiovascular diseases in end-stage renal disease patients. This study aimed to evaluate cTnT as a prognostic value in asymptomatic continuous ambulatory peritoneal dialysis patients. Methods: This is a prospective observational study with 107 prevalent peritoneal dialysis patients. cTnT, high-sensitive C-reactive protein (hsCRP) and IL-6 were measured at baseline. Based on cTnT level, patients were classified as higher cTnT group (HT, n = 21, cTnT ≥0.1 ng/ml) and lower cTnT group (LT, n = 86, cTnT <0.1 ng/ml), and were followed for 3 years. Primary endpoint was cardiovascular events. Results: The HT group had a significantly higher level of log hsCRP and log IL-6 than the LT group (p < 0.05). Kaplan-Meier survival demonstrated worse cardiovascular event-free survival for the HT group. Multivariate analysis adjusted for age, cTnT, IL-6 and hsCRP level revealed that age (per 1-year increase, HR 1.07, p < 0.05), elevated cTnT (vs. <0.1 ng/ml, HR 5.89, p < 0.05) and hsCRP (vs. <3.0 mg/l, HR 4.15, p < 0.05) were identified as significant determinants of cardiovascular events. Conclusion: This study suggests that cTnT may be an aid in risk stratification of continuous ambulatory peritoneal dialysis patients.",
author = "Han, {Seung Hyeok} and Choi, {Hoon Young} and Kim, {Dong Ki} and Moon, {Sung Jin} and Lee, {Jung Eun} and Yoo, {Tae Hyun} and Kim, {Beom Seok} and Kang, {Shin Wook} and Choi, {Kyu Hun} and Lee, {Ho Yung} and Han, {Dae Suk}",
year = "2009",
month = "1",
day = "1",
doi = "10.1159/000151634",
language = "English",
volume = "29",
pages = "129--135",
journal = "American Journal of Nephrology",
issn = "0250-8095",
publisher = "S. Karger AG",
number = "2",

}

Elevated cardiac troponin T predicts cardiovascular events in asymptomatic continuous ambulatory peritoneal dialysis patients without a history of cardiovascular disease. / Han, Seung Hyeok; Choi, Hoon Young; Kim, Dong Ki; Moon, Sung Jin; Lee, Jung Eun; Yoo, Tae Hyun; Kim, Beom Seok; Kang, Shin Wook; Choi, Kyu Hun; Lee, Ho Yung; Han, Dae Suk.

In: American Journal of Nephrology, Vol. 29, No. 2, 01.01.2009, p. 129-135.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Elevated cardiac troponin T predicts cardiovascular events in asymptomatic continuous ambulatory peritoneal dialysis patients without a history of cardiovascular disease

AU - Han, Seung Hyeok

AU - Choi, Hoon Young

AU - Kim, Dong Ki

AU - Moon, Sung Jin

AU - Lee, Jung Eun

AU - Yoo, Tae Hyun

AU - Kim, Beom Seok

AU - Kang, Shin Wook

AU - Choi, Kyu Hun

AU - Lee, Ho Yung

AU - Han, Dae Suk

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Background: Recent studies revealed that elevated cardiac troponin T (cTnT) could predict all-cause mortality and cardiovascular diseases in end-stage renal disease patients. This study aimed to evaluate cTnT as a prognostic value in asymptomatic continuous ambulatory peritoneal dialysis patients. Methods: This is a prospective observational study with 107 prevalent peritoneal dialysis patients. cTnT, high-sensitive C-reactive protein (hsCRP) and IL-6 were measured at baseline. Based on cTnT level, patients were classified as higher cTnT group (HT, n = 21, cTnT ≥0.1 ng/ml) and lower cTnT group (LT, n = 86, cTnT <0.1 ng/ml), and were followed for 3 years. Primary endpoint was cardiovascular events. Results: The HT group had a significantly higher level of log hsCRP and log IL-6 than the LT group (p < 0.05). Kaplan-Meier survival demonstrated worse cardiovascular event-free survival for the HT group. Multivariate analysis adjusted for age, cTnT, IL-6 and hsCRP level revealed that age (per 1-year increase, HR 1.07, p < 0.05), elevated cTnT (vs. <0.1 ng/ml, HR 5.89, p < 0.05) and hsCRP (vs. <3.0 mg/l, HR 4.15, p < 0.05) were identified as significant determinants of cardiovascular events. Conclusion: This study suggests that cTnT may be an aid in risk stratification of continuous ambulatory peritoneal dialysis patients.

AB - Background: Recent studies revealed that elevated cardiac troponin T (cTnT) could predict all-cause mortality and cardiovascular diseases in end-stage renal disease patients. This study aimed to evaluate cTnT as a prognostic value in asymptomatic continuous ambulatory peritoneal dialysis patients. Methods: This is a prospective observational study with 107 prevalent peritoneal dialysis patients. cTnT, high-sensitive C-reactive protein (hsCRP) and IL-6 were measured at baseline. Based on cTnT level, patients were classified as higher cTnT group (HT, n = 21, cTnT ≥0.1 ng/ml) and lower cTnT group (LT, n = 86, cTnT <0.1 ng/ml), and were followed for 3 years. Primary endpoint was cardiovascular events. Results: The HT group had a significantly higher level of log hsCRP and log IL-6 than the LT group (p < 0.05). Kaplan-Meier survival demonstrated worse cardiovascular event-free survival for the HT group. Multivariate analysis adjusted for age, cTnT, IL-6 and hsCRP level revealed that age (per 1-year increase, HR 1.07, p < 0.05), elevated cTnT (vs. <0.1 ng/ml, HR 5.89, p < 0.05) and hsCRP (vs. <3.0 mg/l, HR 4.15, p < 0.05) were identified as significant determinants of cardiovascular events. Conclusion: This study suggests that cTnT may be an aid in risk stratification of continuous ambulatory peritoneal dialysis patients.

UR - http://www.scopus.com/inward/record.url?scp=49849102445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49849102445&partnerID=8YFLogxK

U2 - 10.1159/000151634

DO - 10.1159/000151634

M3 - Article

C2 - 18719346

AN - SCOPUS:49849102445

VL - 29

SP - 129

EP - 135

JO - American Journal of Nephrology

JF - American Journal of Nephrology

SN - 0250-8095

IS - 2

ER -