Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina

An intravascular ultrasound study

Myeongki Hong, Seong Wook Park, Whan Cheol Lee, Si Wan Choi, Jong Min Song, Duk Hyun Kang, Jae Kwan Song, Jae Joong Kim, Seung Jung Park

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: The relationship between plasma biologic markers and coronary artery remodeling is unknown. Hypothesis: Plasma biologic markers are associated with coronary artery remodeling. Methods: Preintervention intravascular ultrasound images were obtained in 44 patients with chronic stable angina. Plasma samples were collected 24 h before coronary intervention. The biologic markers included total cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, lipoprotein(a) [LP(a)], C-reactive protein (CRP), and homocysteine. The remodeling index (RI) was defined as a ratio of the (lesion/proximal reference) external elastic membrane cross-sectional area. Positive remodeling was defined as an RI > 1.05, negative remodeling as an RI <0.95, and intermediate remodeling as an RI between 0.95 and 1.05. Results: Total cholesterol level (r = 0.092, p = 0.557), LDL cholesterol level (r = 0.123, p = 0.426), triglyceride level (r = 0.020, p = 0.901), HDL cholesterol level (r = 0.042, p = 0.789), LP(a) level (r = 0.062, p = 0.729), and CRP level (r = 0.266, p = 0.089) did not significantly correlate with the RI. However, the plasma homocysteine level positively correlated with the RI (r = 0.398, p = 0.008). The plasma homocysteine level was significantly lower in the lesions with negative remodeling and higher in the lesions with positive remodeling (10.8 ± 0.7 μmol/l in negative remodeling, 13.1 ± 0.6 μmol/l in intermediate remodeling, and 18.1 ± 2.8 μmol/l in positive remodeling, p = 0.021). Conclusions: Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalClinical Cardiology
Volume25
Issue number5
DOIs
Publication statusPublished - 2002 Jan 1

Fingerprint

Stable Angina
Homocysteine
Coronary Vessels
HDL Cholesterol
Lipoprotein(a)
Biomarkers
C-Reactive Protein
LDL Cholesterol
Cholesterol
Triglycerides
Membranes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hong, Myeongki ; Park, Seong Wook ; Lee, Whan Cheol ; Choi, Si Wan ; Song, Jong Min ; Kang, Duk Hyun ; Song, Jae Kwan ; Kim, Jae Joong ; Park, Seung Jung. / Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina : An intravascular ultrasound study. In: Clinical Cardiology. 2002 ; Vol. 25, No. 5. pp. 225-229.
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title = "Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina: An intravascular ultrasound study",
abstract = "Background: The relationship between plasma biologic markers and coronary artery remodeling is unknown. Hypothesis: Plasma biologic markers are associated with coronary artery remodeling. Methods: Preintervention intravascular ultrasound images were obtained in 44 patients with chronic stable angina. Plasma samples were collected 24 h before coronary intervention. The biologic markers included total cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, lipoprotein(a) [LP(a)], C-reactive protein (CRP), and homocysteine. The remodeling index (RI) was defined as a ratio of the (lesion/proximal reference) external elastic membrane cross-sectional area. Positive remodeling was defined as an RI > 1.05, negative remodeling as an RI <0.95, and intermediate remodeling as an RI between 0.95 and 1.05. Results: Total cholesterol level (r = 0.092, p = 0.557), LDL cholesterol level (r = 0.123, p = 0.426), triglyceride level (r = 0.020, p = 0.901), HDL cholesterol level (r = 0.042, p = 0.789), LP(a) level (r = 0.062, p = 0.729), and CRP level (r = 0.266, p = 0.089) did not significantly correlate with the RI. However, the plasma homocysteine level positively correlated with the RI (r = 0.398, p = 0.008). The plasma homocysteine level was significantly lower in the lesions with negative remodeling and higher in the lesions with positive remodeling (10.8 ± 0.7 μmol/l in negative remodeling, 13.1 ± 0.6 μmol/l in intermediate remodeling, and 18.1 ± 2.8 μmol/l in positive remodeling, p = 0.021). Conclusions: Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina.",
author = "Myeongki Hong and Park, {Seong Wook} and Lee, {Whan Cheol} and Choi, {Si Wan} and Song, {Jong Min} and Kang, {Duk Hyun} and Song, {Jae Kwan} and Kim, {Jae Joong} and Park, {Seung Jung}",
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Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina : An intravascular ultrasound study. / Hong, Myeongki; Park, Seong Wook; Lee, Whan Cheol; Choi, Si Wan; Song, Jong Min; Kang, Duk Hyun; Song, Jae Kwan; Kim, Jae Joong; Park, Seung Jung.

In: Clinical Cardiology, Vol. 25, No. 5, 01.01.2002, p. 225-229.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina

T2 - An intravascular ultrasound study

AU - Hong, Myeongki

AU - Park, Seong Wook

AU - Lee, Whan Cheol

AU - Choi, Si Wan

AU - Song, Jong Min

AU - Kang, Duk Hyun

AU - Song, Jae Kwan

AU - Kim, Jae Joong

AU - Park, Seung Jung

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Background: The relationship between plasma biologic markers and coronary artery remodeling is unknown. Hypothesis: Plasma biologic markers are associated with coronary artery remodeling. Methods: Preintervention intravascular ultrasound images were obtained in 44 patients with chronic stable angina. Plasma samples were collected 24 h before coronary intervention. The biologic markers included total cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, lipoprotein(a) [LP(a)], C-reactive protein (CRP), and homocysteine. The remodeling index (RI) was defined as a ratio of the (lesion/proximal reference) external elastic membrane cross-sectional area. Positive remodeling was defined as an RI > 1.05, negative remodeling as an RI <0.95, and intermediate remodeling as an RI between 0.95 and 1.05. Results: Total cholesterol level (r = 0.092, p = 0.557), LDL cholesterol level (r = 0.123, p = 0.426), triglyceride level (r = 0.020, p = 0.901), HDL cholesterol level (r = 0.042, p = 0.789), LP(a) level (r = 0.062, p = 0.729), and CRP level (r = 0.266, p = 0.089) did not significantly correlate with the RI. However, the plasma homocysteine level positively correlated with the RI (r = 0.398, p = 0.008). The plasma homocysteine level was significantly lower in the lesions with negative remodeling and higher in the lesions with positive remodeling (10.8 ± 0.7 μmol/l in negative remodeling, 13.1 ± 0.6 μmol/l in intermediate remodeling, and 18.1 ± 2.8 μmol/l in positive remodeling, p = 0.021). Conclusions: Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina.

AB - Background: The relationship between plasma biologic markers and coronary artery remodeling is unknown. Hypothesis: Plasma biologic markers are associated with coronary artery remodeling. Methods: Preintervention intravascular ultrasound images were obtained in 44 patients with chronic stable angina. Plasma samples were collected 24 h before coronary intervention. The biologic markers included total cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, lipoprotein(a) [LP(a)], C-reactive protein (CRP), and homocysteine. The remodeling index (RI) was defined as a ratio of the (lesion/proximal reference) external elastic membrane cross-sectional area. Positive remodeling was defined as an RI > 1.05, negative remodeling as an RI <0.95, and intermediate remodeling as an RI between 0.95 and 1.05. Results: Total cholesterol level (r = 0.092, p = 0.557), LDL cholesterol level (r = 0.123, p = 0.426), triglyceride level (r = 0.020, p = 0.901), HDL cholesterol level (r = 0.042, p = 0.789), LP(a) level (r = 0.062, p = 0.729), and CRP level (r = 0.266, p = 0.089) did not significantly correlate with the RI. However, the plasma homocysteine level positively correlated with the RI (r = 0.398, p = 0.008). The plasma homocysteine level was significantly lower in the lesions with negative remodeling and higher in the lesions with positive remodeling (10.8 ± 0.7 μmol/l in negative remodeling, 13.1 ± 0.6 μmol/l in intermediate remodeling, and 18.1 ± 2.8 μmol/l in positive remodeling, p = 0.021). Conclusions: Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina.

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