Abstract
Background: The relationship between plasma biologic markers and coronary artery remodeling is unknown. Hypothesis: Plasma biologic markers are associated with coronary artery remodeling. Methods: Preintervention intravascular ultrasound images were obtained in 44 patients with chronic stable angina. Plasma samples were collected 24 h before coronary intervention. The biologic markers included total cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, lipoprotein(a) [LP(a)], C-reactive protein (CRP), and homocysteine. The remodeling index (RI) was defined as a ratio of the (lesion/proximal reference) external elastic membrane cross-sectional area. Positive remodeling was defined as an RI > 1.05, negative remodeling as an RI <0.95, and intermediate remodeling as an RI between 0.95 and 1.05. Results: Total cholesterol level (r = 0.092, p = 0.557), LDL cholesterol level (r = 0.123, p = 0.426), triglyceride level (r = 0.020, p = 0.901), HDL cholesterol level (r = 0.042, p = 0.789), LP(a) level (r = 0.062, p = 0.729), and CRP level (r = 0.266, p = 0.089) did not significantly correlate with the RI. However, the plasma homocysteine level positively correlated with the RI (r = 0.398, p = 0.008). The plasma homocysteine level was significantly lower in the lesions with negative remodeling and higher in the lesions with positive remodeling (10.8 ± 0.7 μmol/l in negative remodeling, 13.1 ± 0.6 μmol/l in intermediate remodeling, and 18.1 ± 2.8 μmol/l in positive remodeling, p = 0.021). Conclusions: Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina.
| Original language | English |
|---|---|
| Pages (from-to) | 225-229 |
| Number of pages | 5 |
| Journal | Clinical Cardiology |
| Volume | 25 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2002 Jan 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
}
Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina : An intravascular ultrasound study. / Hong, Myeongki; Park, Seong Wook; Lee, Whan Cheol; Choi, Si Wan; Song, Jong Min; Kang, Duk Hyun; Song, Jae Kwan; Kim, Jae Joong; Park, Seung Jung.
In: Clinical Cardiology, Vol. 25, No. 5, 01.01.2002, p. 225-229.Research output: Contribution to journal › Article
TY - JOUR
T1 - Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina
T2 - An intravascular ultrasound study
AU - Hong, Myeongki
AU - Park, Seong Wook
AU - Lee, Whan Cheol
AU - Choi, Si Wan
AU - Song, Jong Min
AU - Kang, Duk Hyun
AU - Song, Jae Kwan
AU - Kim, Jae Joong
AU - Park, Seung Jung
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Background: The relationship between plasma biologic markers and coronary artery remodeling is unknown. Hypothesis: Plasma biologic markers are associated with coronary artery remodeling. Methods: Preintervention intravascular ultrasound images were obtained in 44 patients with chronic stable angina. Plasma samples were collected 24 h before coronary intervention. The biologic markers included total cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, lipoprotein(a) [LP(a)], C-reactive protein (CRP), and homocysteine. The remodeling index (RI) was defined as a ratio of the (lesion/proximal reference) external elastic membrane cross-sectional area. Positive remodeling was defined as an RI > 1.05, negative remodeling as an RI <0.95, and intermediate remodeling as an RI between 0.95 and 1.05. Results: Total cholesterol level (r = 0.092, p = 0.557), LDL cholesterol level (r = 0.123, p = 0.426), triglyceride level (r = 0.020, p = 0.901), HDL cholesterol level (r = 0.042, p = 0.789), LP(a) level (r = 0.062, p = 0.729), and CRP level (r = 0.266, p = 0.089) did not significantly correlate with the RI. However, the plasma homocysteine level positively correlated with the RI (r = 0.398, p = 0.008). The plasma homocysteine level was significantly lower in the lesions with negative remodeling and higher in the lesions with positive remodeling (10.8 ± 0.7 μmol/l in negative remodeling, 13.1 ± 0.6 μmol/l in intermediate remodeling, and 18.1 ± 2.8 μmol/l in positive remodeling, p = 0.021). Conclusions: Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina.
AB - Background: The relationship between plasma biologic markers and coronary artery remodeling is unknown. Hypothesis: Plasma biologic markers are associated with coronary artery remodeling. Methods: Preintervention intravascular ultrasound images were obtained in 44 patients with chronic stable angina. Plasma samples were collected 24 h before coronary intervention. The biologic markers included total cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, lipoprotein(a) [LP(a)], C-reactive protein (CRP), and homocysteine. The remodeling index (RI) was defined as a ratio of the (lesion/proximal reference) external elastic membrane cross-sectional area. Positive remodeling was defined as an RI > 1.05, negative remodeling as an RI <0.95, and intermediate remodeling as an RI between 0.95 and 1.05. Results: Total cholesterol level (r = 0.092, p = 0.557), LDL cholesterol level (r = 0.123, p = 0.426), triglyceride level (r = 0.020, p = 0.901), HDL cholesterol level (r = 0.042, p = 0.789), LP(a) level (r = 0.062, p = 0.729), and CRP level (r = 0.266, p = 0.089) did not significantly correlate with the RI. However, the plasma homocysteine level positively correlated with the RI (r = 0.398, p = 0.008). The plasma homocysteine level was significantly lower in the lesions with negative remodeling and higher in the lesions with positive remodeling (10.8 ± 0.7 μmol/l in negative remodeling, 13.1 ± 0.6 μmol/l in intermediate remodeling, and 18.1 ± 2.8 μmol/l in positive remodeling, p = 0.021). Conclusions: Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina.
UR - http://www.scopus.com/inward/record.url?scp=0036233982&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036233982&partnerID=8YFLogxK
U2 - 10.1002/clc.4950250506
DO - 10.1002/clc.4950250506
M3 - Article
VL - 25
SP - 225
EP - 229
JO - Clinical Cardiology
JF - Clinical Cardiology
SN - 0160-9289
IS - 5
ER -