Elevated levels of CTRP1 in obesity contribute to tumor progression in a p53-dependent manner

Rackhyun Park, Minsu Jang, Yea In Park, Yeonjeong Park, Sim Namkoong, Jin I. Lee, Junsoo Park

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Mounting evidence supports the relationship between obesity and cancer. However, the molecular mechanisms linking obesity with cancer remain largely uninvestigated. In this study, we demonstrate that the expression of C1q/TNF-related protein 1 (CTRP1), an adiponectin paralogue, contributes to tumor growth by regulating the tumor suppressor p53. In our study, obese mice on a high-fat diet showed higher serum CTRP1 levels. Through in vitro experiments, we showed that the secreted form of CTRP1 in the culture medium decreased p53 expression and p53-dependent transcription in the cells. Moreover, CTRP1 treatment enhanced colony formation and cell migration. These results collectively suggest that elevated levels of CTRP1 in obesity significantly contribute to tumor progression.

Original languageEnglish
Article number3619
Issue number14
Publication statusPublished - 2021 Jul 2

Bibliographical note

Funding Information:
Funding: This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government [2019R1A2C1006511 (J.P.), 2020R1I1A1A01051824 (R.P.)].

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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