Elevated levels of CTRP1 in obesity contribute to tumor progression in a p53-dependent manner

Rackhyun Park; Minsu Jang; Yea In Park; Yeonjeong Park; Sim Namkoong; Jin I. Lee; Junsoo Park

doi:10.3390/cancers13143619

Elevated levels of CTRP1 in obesity contribute to tumor progression in a p53-dependent manner

Rackhyun Park, Minsu Jang, Yea In Park, Yeonjeong Park, Sim Namkoong, Jin I. Lee, Junsoo Park

Division of Bioscience and Biotechnology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Mounting evidence supports the relationship between obesity and cancer. However, the molecular mechanisms linking obesity with cancer remain largely uninvestigated. In this study, we demonstrate that the expression of C1q/TNF-related protein 1 (CTRP1), an adiponectin paralogue, contributes to tumor growth by regulating the tumor suppressor p53. In our study, obese mice on a high-fat diet showed higher serum CTRP1 levels. Through in vitro experiments, we showed that the secreted form of CTRP1 in the culture medium decreased p53 expression and p53-dependent transcription in the cells. Moreover, CTRP1 treatment enhanced colony formation and cell migration. These results collectively suggest that elevated levels of CTRP1 in obesity significantly contribute to tumor progression.

Original language	English
Article number	3619
Journal	Cancers
Volume	13
Issue number	14
DOIs	https://doi.org/10.3390/cancers13143619
Publication status	Published - 2021 Jul 2

Bibliographical note

Funding Information:
Funding: This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government [2019R1A2C1006511 (J.P.), 2020R1I1A1A01051824 (R.P.)].

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers13143619

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title = "Elevated levels of CTRP1 in obesity contribute to tumor progression in a p53-dependent manner",

abstract = "Mounting evidence supports the relationship between obesity and cancer. However, the molecular mechanisms linking obesity with cancer remain largely uninvestigated. In this study, we demonstrate that the expression of C1q/TNF-related protein 1 (CTRP1), an adiponectin paralogue, contributes to tumor growth by regulating the tumor suppressor p53. In our study, obese mice on a high-fat diet showed higher serum CTRP1 levels. Through in vitro experiments, we showed that the secreted form of CTRP1 in the culture medium decreased p53 expression and p53-dependent transcription in the cells. Moreover, CTRP1 treatment enhanced colony formation and cell migration. These results collectively suggest that elevated levels of CTRP1 in obesity significantly contribute to tumor progression.",

author = "Rackhyun Park and Minsu Jang and Park, {Yea In} and Yeonjeong Park and Sim Namkoong and Lee, {Jin I.} and Junsoo Park",

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AU - Park, Rackhyun

AU - Jang, Minsu

AU - Park, Yea In

AU - Park, Yeonjeong

AU - Namkoong, Sim

AU - Lee, Jin I.

AU - Park, Junsoo

N1 - Funding Information: Funding: This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government [2019R1A2C1006511 (J.P.), 2020R1I1A1A01051824 (R.P.)]. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/7/2

Y1 - 2021/7/2

N2 - Mounting evidence supports the relationship between obesity and cancer. However, the molecular mechanisms linking obesity with cancer remain largely uninvestigated. In this study, we demonstrate that the expression of C1q/TNF-related protein 1 (CTRP1), an adiponectin paralogue, contributes to tumor growth by regulating the tumor suppressor p53. In our study, obese mice on a high-fat diet showed higher serum CTRP1 levels. Through in vitro experiments, we showed that the secreted form of CTRP1 in the culture medium decreased p53 expression and p53-dependent transcription in the cells. Moreover, CTRP1 treatment enhanced colony formation and cell migration. These results collectively suggest that elevated levels of CTRP1 in obesity significantly contribute to tumor progression.

AB - Mounting evidence supports the relationship between obesity and cancer. However, the molecular mechanisms linking obesity with cancer remain largely uninvestigated. In this study, we demonstrate that the expression of C1q/TNF-related protein 1 (CTRP1), an adiponectin paralogue, contributes to tumor growth by regulating the tumor suppressor p53. In our study, obese mice on a high-fat diet showed higher serum CTRP1 levels. Through in vitro experiments, we showed that the secreted form of CTRP1 in the culture medium decreased p53 expression and p53-dependent transcription in the cells. Moreover, CTRP1 treatment enhanced colony formation and cell migration. These results collectively suggest that elevated levels of CTRP1 in obesity significantly contribute to tumor progression.

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Elevated levels of CTRP1 in obesity contribute to tumor progression in a p53-dependent manner

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

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