Elevated levels of preoperative CA 15-3 and CEA serum levels have independently poor prognostic significance in breast cancer

J. S. Lee, S. Park, J. M. Park, J. H. Cho, S. I. Kim, Byeongwoo Park

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: To evaluate the prognostic value of preoperative tumor markers, cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA), in breast cancers. Patients and methods: Preoperative CA 15-3 and CEA levels of 1681 patients were measured. The association of both tumor markers levels with clinicopathological parameters and outcomes was investigated by univariate and multivariate analyses. Results: Among 1681 patients, elevated preoperative CA15-3 and CEA levels were identified in 176 and 131 patients, respectively. Higher preoperative CA 15-3 and CEA levels were significantly associated with a larger tumor size, axillary node metastases, and advanced stage. Patients with elevated CA 15-3 and CEA levels showed worse survival, even in stage-matched analysis. Patients with normal levels of both CA15-3 and CEA showed better survival than those with one or both markers levels elevated. In multivariate analysis, elevated preoperative CA 15-3 and CEA levels were independent prognostic factors. The statistical significance of elevated preoperative tumor markers levels on survival was solidified with longer follow-up and larger study population. Conclusions: Elevated preoperative CA 15-3 and CEA levels are associated with tumor burden and showed independent prognostic significance. Therefore, new treatment strategies are necessary for patients with elevated preoperative CA 15-3 and CEA levels in clinical practice.

Original languageEnglish
Article numbermds604
Pages (from-to)1225-1231
Number of pages7
JournalAnnals of Oncology
Volume24
Issue number5
DOIs
Publication statusPublished - 2013 May 1

Fingerprint

Carcinoembryonic Antigen
Breast Neoplasms
Antigens
Serum
Neoplasms
Tumor Biomarkers
Survival
Multivariate Analysis
Differentiation Antigens
Tumor Burden
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

Cite this

Lee, J. S. ; Park, S. ; Park, J. M. ; Cho, J. H. ; Kim, S. I. ; Park, Byeongwoo. / Elevated levels of preoperative CA 15-3 and CEA serum levels have independently poor prognostic significance in breast cancer. In: Annals of Oncology. 2013 ; Vol. 24, No. 5. pp. 1225-1231.
@article{fcaecb76f5864e72a3e56783a2a2004f,
title = "Elevated levels of preoperative CA 15-3 and CEA serum levels have independently poor prognostic significance in breast cancer",
abstract = "Background: To evaluate the prognostic value of preoperative tumor markers, cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA), in breast cancers. Patients and methods: Preoperative CA 15-3 and CEA levels of 1681 patients were measured. The association of both tumor markers levels with clinicopathological parameters and outcomes was investigated by univariate and multivariate analyses. Results: Among 1681 patients, elevated preoperative CA15-3 and CEA levels were identified in 176 and 131 patients, respectively. Higher preoperative CA 15-3 and CEA levels were significantly associated with a larger tumor size, axillary node metastases, and advanced stage. Patients with elevated CA 15-3 and CEA levels showed worse survival, even in stage-matched analysis. Patients with normal levels of both CA15-3 and CEA showed better survival than those with one or both markers levels elevated. In multivariate analysis, elevated preoperative CA 15-3 and CEA levels were independent prognostic factors. The statistical significance of elevated preoperative tumor markers levels on survival was solidified with longer follow-up and larger study population. Conclusions: Elevated preoperative CA 15-3 and CEA levels are associated with tumor burden and showed independent prognostic significance. Therefore, new treatment strategies are necessary for patients with elevated preoperative CA 15-3 and CEA levels in clinical practice.",
author = "Lee, {J. S.} and S. Park and Park, {J. M.} and Cho, {J. H.} and Kim, {S. I.} and Byeongwoo Park",
year = "2013",
month = "5",
day = "1",
doi = "10.1093/annonc/mds604",
language = "English",
volume = "24",
pages = "1225--1231",
journal = "Annals of Oncology",
issn = "0923-7534",
publisher = "Oxford University Press",
number = "5",

}

Elevated levels of preoperative CA 15-3 and CEA serum levels have independently poor prognostic significance in breast cancer. / Lee, J. S.; Park, S.; Park, J. M.; Cho, J. H.; Kim, S. I.; Park, Byeongwoo.

In: Annals of Oncology, Vol. 24, No. 5, mds604, 01.05.2013, p. 1225-1231.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Elevated levels of preoperative CA 15-3 and CEA serum levels have independently poor prognostic significance in breast cancer

AU - Lee, J. S.

AU - Park, S.

AU - Park, J. M.

AU - Cho, J. H.

AU - Kim, S. I.

AU - Park, Byeongwoo

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Background: To evaluate the prognostic value of preoperative tumor markers, cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA), in breast cancers. Patients and methods: Preoperative CA 15-3 and CEA levels of 1681 patients were measured. The association of both tumor markers levels with clinicopathological parameters and outcomes was investigated by univariate and multivariate analyses. Results: Among 1681 patients, elevated preoperative CA15-3 and CEA levels were identified in 176 and 131 patients, respectively. Higher preoperative CA 15-3 and CEA levels were significantly associated with a larger tumor size, axillary node metastases, and advanced stage. Patients with elevated CA 15-3 and CEA levels showed worse survival, even in stage-matched analysis. Patients with normal levels of both CA15-3 and CEA showed better survival than those with one or both markers levels elevated. In multivariate analysis, elevated preoperative CA 15-3 and CEA levels were independent prognostic factors. The statistical significance of elevated preoperative tumor markers levels on survival was solidified with longer follow-up and larger study population. Conclusions: Elevated preoperative CA 15-3 and CEA levels are associated with tumor burden and showed independent prognostic significance. Therefore, new treatment strategies are necessary for patients with elevated preoperative CA 15-3 and CEA levels in clinical practice.

AB - Background: To evaluate the prognostic value of preoperative tumor markers, cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA), in breast cancers. Patients and methods: Preoperative CA 15-3 and CEA levels of 1681 patients were measured. The association of both tumor markers levels with clinicopathological parameters and outcomes was investigated by univariate and multivariate analyses. Results: Among 1681 patients, elevated preoperative CA15-3 and CEA levels were identified in 176 and 131 patients, respectively. Higher preoperative CA 15-3 and CEA levels were significantly associated with a larger tumor size, axillary node metastases, and advanced stage. Patients with elevated CA 15-3 and CEA levels showed worse survival, even in stage-matched analysis. Patients with normal levels of both CA15-3 and CEA showed better survival than those with one or both markers levels elevated. In multivariate analysis, elevated preoperative CA 15-3 and CEA levels were independent prognostic factors. The statistical significance of elevated preoperative tumor markers levels on survival was solidified with longer follow-up and larger study population. Conclusions: Elevated preoperative CA 15-3 and CEA levels are associated with tumor burden and showed independent prognostic significance. Therefore, new treatment strategies are necessary for patients with elevated preoperative CA 15-3 and CEA levels in clinical practice.

UR - http://www.scopus.com/inward/record.url?scp=84877152314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877152314&partnerID=8YFLogxK

U2 - 10.1093/annonc/mds604

DO - 10.1093/annonc/mds604

M3 - Article

VL - 24

SP - 1225

EP - 1231

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

IS - 5

M1 - mds604

ER -