Elevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients

Hyang Mo Koo, Hwa Mi Do, Eun Jin Kim, Mi Jung Lee, Dong Ho Shin, Seung Jun Kim, Hyung Jung Oh, Dong Eun Yoo, Jwa Kyung Kim, Jung Tak Park, Seung Hyeok Han, Shin Wook Kang, Kyu Hun Choi, Tae Hyun Yoo

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Backgrounds: Osteoprotegerin (OPG) is known to regulate bone mineral metabolism and to be also associated with inflammation, cardiovascular disease (CVD) and mortality. Malnutrition-inflammation-atherosclerosis (MIA) syndrome is commonly found and closely linked to mortality in dialysis patients. The aim of this study was to investigate the associations between OPG and MIA syndrome in prevalent peritoneal dialysis (PD) patients. Methods: Prevalent PD patients for more than 6 months were prospectively followed up from March 2005 to May 2010. At baseline, OPG, hs-CRP, albumin, and %lean body mass (LBM) by creatinine kinetics were checked, and subjective global assessment (SGA) was performed. New-onset cardiovascular events were evaluated during the study period. Based on the median level of OPG, patients were classified as lower OPG (LO) group (n= 88) and higher OPG (HO) group (n= 88). Results: A total of 176 patients (age 52.0 ± 11.8 years, male 50.6%, duration of PD 105.3 ± 67.2 months) were recruited and followed. In HO group, age, hs-CRP level and Charlson's comorbidity indices were higher, whereas serum albumin level, %LBM and SGA score were significantly lower than LO group. OPG levels were positively correlated with inflammatory markers, whereas negatively correlated with nutritional status. Cardiovascular events occurred in 51 patients during the study period. Newly developed cardiovascular events were significantly common in HO group (n= 36, 40.9%) than LO group (n= 15, 17%, p= 0.002). Cox regression analysis revealed that higher OPG level (per 1-SD increase in OPG, HR: 1.44; 95% CI: 1.03-2.00; p= 0.034) was a significant risk factor for cardiovascular events even after adjustments for demographic and biochemical parameters. Conclusion: OPG was significantly correlated with markers of systemic inflammation and malnutrition and was a significant predictor of CVD in PD patients. These findings suggest OPG might be a prognostic indicator of MIA syndrome in prevalent PD patients.

Original languageEnglish
Pages (from-to)925-930
Number of pages6
JournalAtherosclerosis
Volume219
Issue number2
DOIs
Publication statusPublished - 2011 Dec 1

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Osteoprotegerin
Peritoneal Dialysis
Malnutrition
Inflammation
Atherosclerosis
Cardiovascular Diseases
Mortality
Nutritional Status
Serum Albumin
Minerals
Comorbidity
Dialysis
Albumins
Creatinine
Regression Analysis
Demography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Koo, Hyang Mo ; Do, Hwa Mi ; Kim, Eun Jin ; Lee, Mi Jung ; Shin, Dong Ho ; Kim, Seung Jun ; Oh, Hyung Jung ; Yoo, Dong Eun ; Kim, Jwa Kyung ; Park, Jung Tak ; Han, Seung Hyeok ; Kang, Shin Wook ; Choi, Kyu Hun ; Yoo, Tae Hyun. / Elevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients. In: Atherosclerosis. 2011 ; Vol. 219, No. 2. pp. 925-930.
@article{c0cff792eba647d9b41e958cff4b3458,
title = "Elevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients",
abstract = "Backgrounds: Osteoprotegerin (OPG) is known to regulate bone mineral metabolism and to be also associated with inflammation, cardiovascular disease (CVD) and mortality. Malnutrition-inflammation-atherosclerosis (MIA) syndrome is commonly found and closely linked to mortality in dialysis patients. The aim of this study was to investigate the associations between OPG and MIA syndrome in prevalent peritoneal dialysis (PD) patients. Methods: Prevalent PD patients for more than 6 months were prospectively followed up from March 2005 to May 2010. At baseline, OPG, hs-CRP, albumin, and {\%}lean body mass (LBM) by creatinine kinetics were checked, and subjective global assessment (SGA) was performed. New-onset cardiovascular events were evaluated during the study period. Based on the median level of OPG, patients were classified as lower OPG (LO) group (n= 88) and higher OPG (HO) group (n= 88). Results: A total of 176 patients (age 52.0 ± 11.8 years, male 50.6{\%}, duration of PD 105.3 ± 67.2 months) were recruited and followed. In HO group, age, hs-CRP level and Charlson's comorbidity indices were higher, whereas serum albumin level, {\%}LBM and SGA score were significantly lower than LO group. OPG levels were positively correlated with inflammatory markers, whereas negatively correlated with nutritional status. Cardiovascular events occurred in 51 patients during the study period. Newly developed cardiovascular events were significantly common in HO group (n= 36, 40.9{\%}) than LO group (n= 15, 17{\%}, p= 0.002). Cox regression analysis revealed that higher OPG level (per 1-SD increase in OPG, HR: 1.44; 95{\%} CI: 1.03-2.00; p= 0.034) was a significant risk factor for cardiovascular events even after adjustments for demographic and biochemical parameters. Conclusion: OPG was significantly correlated with markers of systemic inflammation and malnutrition and was a significant predictor of CVD in PD patients. These findings suggest OPG might be a prognostic indicator of MIA syndrome in prevalent PD patients.",
author = "Koo, {Hyang Mo} and Do, {Hwa Mi} and Kim, {Eun Jin} and Lee, {Mi Jung} and Shin, {Dong Ho} and Kim, {Seung Jun} and Oh, {Hyung Jung} and Yoo, {Dong Eun} and Kim, {Jwa Kyung} and Park, {Jung Tak} and Han, {Seung Hyeok} and Kang, {Shin Wook} and Choi, {Kyu Hun} and Yoo, {Tae Hyun}",
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Elevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients. / Koo, Hyang Mo; Do, Hwa Mi; Kim, Eun Jin; Lee, Mi Jung; Shin, Dong Ho; Kim, Seung Jun; Oh, Hyung Jung; Yoo, Dong Eun; Kim, Jwa Kyung; Park, Jung Tak; Han, Seung Hyeok; Kang, Shin Wook; Choi, Kyu Hun; Yoo, Tae Hyun.

In: Atherosclerosis, Vol. 219, No. 2, 01.12.2011, p. 925-930.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Elevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients

AU - Koo, Hyang Mo

AU - Do, Hwa Mi

AU - Kim, Eun Jin

AU - Lee, Mi Jung

AU - Shin, Dong Ho

AU - Kim, Seung Jun

AU - Oh, Hyung Jung

AU - Yoo, Dong Eun

AU - Kim, Jwa Kyung

AU - Park, Jung Tak

AU - Han, Seung Hyeok

AU - Kang, Shin Wook

AU - Choi, Kyu Hun

AU - Yoo, Tae Hyun

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Backgrounds: Osteoprotegerin (OPG) is known to regulate bone mineral metabolism and to be also associated with inflammation, cardiovascular disease (CVD) and mortality. Malnutrition-inflammation-atherosclerosis (MIA) syndrome is commonly found and closely linked to mortality in dialysis patients. The aim of this study was to investigate the associations between OPG and MIA syndrome in prevalent peritoneal dialysis (PD) patients. Methods: Prevalent PD patients for more than 6 months were prospectively followed up from March 2005 to May 2010. At baseline, OPG, hs-CRP, albumin, and %lean body mass (LBM) by creatinine kinetics were checked, and subjective global assessment (SGA) was performed. New-onset cardiovascular events were evaluated during the study period. Based on the median level of OPG, patients were classified as lower OPG (LO) group (n= 88) and higher OPG (HO) group (n= 88). Results: A total of 176 patients (age 52.0 ± 11.8 years, male 50.6%, duration of PD 105.3 ± 67.2 months) were recruited and followed. In HO group, age, hs-CRP level and Charlson's comorbidity indices were higher, whereas serum albumin level, %LBM and SGA score were significantly lower than LO group. OPG levels were positively correlated with inflammatory markers, whereas negatively correlated with nutritional status. Cardiovascular events occurred in 51 patients during the study period. Newly developed cardiovascular events were significantly common in HO group (n= 36, 40.9%) than LO group (n= 15, 17%, p= 0.002). Cox regression analysis revealed that higher OPG level (per 1-SD increase in OPG, HR: 1.44; 95% CI: 1.03-2.00; p= 0.034) was a significant risk factor for cardiovascular events even after adjustments for demographic and biochemical parameters. Conclusion: OPG was significantly correlated with markers of systemic inflammation and malnutrition and was a significant predictor of CVD in PD patients. These findings suggest OPG might be a prognostic indicator of MIA syndrome in prevalent PD patients.

AB - Backgrounds: Osteoprotegerin (OPG) is known to regulate bone mineral metabolism and to be also associated with inflammation, cardiovascular disease (CVD) and mortality. Malnutrition-inflammation-atherosclerosis (MIA) syndrome is commonly found and closely linked to mortality in dialysis patients. The aim of this study was to investigate the associations between OPG and MIA syndrome in prevalent peritoneal dialysis (PD) patients. Methods: Prevalent PD patients for more than 6 months were prospectively followed up from March 2005 to May 2010. At baseline, OPG, hs-CRP, albumin, and %lean body mass (LBM) by creatinine kinetics were checked, and subjective global assessment (SGA) was performed. New-onset cardiovascular events were evaluated during the study period. Based on the median level of OPG, patients were classified as lower OPG (LO) group (n= 88) and higher OPG (HO) group (n= 88). Results: A total of 176 patients (age 52.0 ± 11.8 years, male 50.6%, duration of PD 105.3 ± 67.2 months) were recruited and followed. In HO group, age, hs-CRP level and Charlson's comorbidity indices were higher, whereas serum albumin level, %LBM and SGA score were significantly lower than LO group. OPG levels were positively correlated with inflammatory markers, whereas negatively correlated with nutritional status. Cardiovascular events occurred in 51 patients during the study period. Newly developed cardiovascular events were significantly common in HO group (n= 36, 40.9%) than LO group (n= 15, 17%, p= 0.002). Cox regression analysis revealed that higher OPG level (per 1-SD increase in OPG, HR: 1.44; 95% CI: 1.03-2.00; p= 0.034) was a significant risk factor for cardiovascular events even after adjustments for demographic and biochemical parameters. Conclusion: OPG was significantly correlated with markers of systemic inflammation and malnutrition and was a significant predictor of CVD in PD patients. These findings suggest OPG might be a prognostic indicator of MIA syndrome in prevalent PD patients.

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