Elevated oxidized low-density lipoprotein concentrations in postmenopausal women with the metabolic syndrome

Sung Hee Park, Ji Young Kim, Jong Ho Lee, Hyun Young Park

Research output: Contribution to journalArticle

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Abstract

Background: Low-density lipoprotein cholesterol (LDL-C) and oxidized low-density lipoprotein (ox-LDL) are probably associated with atherosclerosis and coronary artery disease. The influence of LDL-C and ox-LDL on metabolic syndrome among healthy, postmenopausal women has not been well studied. The aim of this study was to assess the association between LDL-C, ox-LDL, and metabolic syndrome in postmenopausal women. Methods: The study design was a cross-sectional study. A total of 1309 postmenopausal women (355 with metabolic syndrome and 954 without metabolic syndrome) aged 60-79. years were included. Lipid profiles, glucose, ox-LDL, adiponectin, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α concentrations were measured. Results: Plasma ox-LDL levels were higher in subjects with metabolic syndrome, when compared without metabolic syndrome subjects. A multiple linear regression analysis revealed that ox-LDL was significantly associated with high-density lipoprotein cholesterol, LDL-C, triglycerides, and adiponectin. After a multivariable adjustment, the odds ratios for the second, third, and fourth quartiles of ox-LDL in metabolic syndrome compared with the lowest quartile were 1.76 (95% confidence interval [CI], 1.15-2.70), 2.45 (95% CI, 1.58-3.79), and 3.98 (95% CI, 2.52-6.28), respectively. LDL levels were not significantly associated with metabolic syndrome. Conclusions: Ox-LDL concentration was associated with metabolic syndrome in postmenopausal women. These findings suggest that high ox-LDL levels are associated with high cardiovascular risk in postmenopausal women with metabolic syndrome.

Original languageEnglish
Pages (from-to)435-440
Number of pages6
JournalClinica Chimica Acta
Volume412
Issue number5-6
DOIs
Publication statusPublished - 2011 Feb 20

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LDL Cholesterol
Adiponectin
Confidence Intervals
oxidized low density lipoprotein
Interleukin-1
Linear regression
Regression analysis
HDL Cholesterol
Coronary Artery Disease
Linear Models
Interleukin-6
Atherosclerosis
Triglycerides
Tumor Necrosis Factor-alpha
Cross-Sectional Studies
Odds Ratio
Regression Analysis
Lipids
Plasmas
Glucose

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Park, Sung Hee ; Kim, Ji Young ; Lee, Jong Ho ; Park, Hyun Young. / Elevated oxidized low-density lipoprotein concentrations in postmenopausal women with the metabolic syndrome. In: Clinica Chimica Acta. 2011 ; Vol. 412, No. 5-6. pp. 435-440.
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abstract = "Background: Low-density lipoprotein cholesterol (LDL-C) and oxidized low-density lipoprotein (ox-LDL) are probably associated with atherosclerosis and coronary artery disease. The influence of LDL-C and ox-LDL on metabolic syndrome among healthy, postmenopausal women has not been well studied. The aim of this study was to assess the association between LDL-C, ox-LDL, and metabolic syndrome in postmenopausal women. Methods: The study design was a cross-sectional study. A total of 1309 postmenopausal women (355 with metabolic syndrome and 954 without metabolic syndrome) aged 60-79. years were included. Lipid profiles, glucose, ox-LDL, adiponectin, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α concentrations were measured. Results: Plasma ox-LDL levels were higher in subjects with metabolic syndrome, when compared without metabolic syndrome subjects. A multiple linear regression analysis revealed that ox-LDL was significantly associated with high-density lipoprotein cholesterol, LDL-C, triglycerides, and adiponectin. After a multivariable adjustment, the odds ratios for the second, third, and fourth quartiles of ox-LDL in metabolic syndrome compared with the lowest quartile were 1.76 (95{\%} confidence interval [CI], 1.15-2.70), 2.45 (95{\%} CI, 1.58-3.79), and 3.98 (95{\%} CI, 2.52-6.28), respectively. LDL levels were not significantly associated with metabolic syndrome. Conclusions: Ox-LDL concentration was associated with metabolic syndrome in postmenopausal women. These findings suggest that high ox-LDL levels are associated with high cardiovascular risk in postmenopausal women with metabolic syndrome.",
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Elevated oxidized low-density lipoprotein concentrations in postmenopausal women with the metabolic syndrome. / Park, Sung Hee; Kim, Ji Young; Lee, Jong Ho; Park, Hyun Young.

In: Clinica Chimica Acta, Vol. 412, No. 5-6, 20.02.2011, p. 435-440.

Research output: Contribution to journalArticle

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N2 - Background: Low-density lipoprotein cholesterol (LDL-C) and oxidized low-density lipoprotein (ox-LDL) are probably associated with atherosclerosis and coronary artery disease. The influence of LDL-C and ox-LDL on metabolic syndrome among healthy, postmenopausal women has not been well studied. The aim of this study was to assess the association between LDL-C, ox-LDL, and metabolic syndrome in postmenopausal women. Methods: The study design was a cross-sectional study. A total of 1309 postmenopausal women (355 with metabolic syndrome and 954 without metabolic syndrome) aged 60-79. years were included. Lipid profiles, glucose, ox-LDL, adiponectin, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α concentrations were measured. Results: Plasma ox-LDL levels were higher in subjects with metabolic syndrome, when compared without metabolic syndrome subjects. A multiple linear regression analysis revealed that ox-LDL was significantly associated with high-density lipoprotein cholesterol, LDL-C, triglycerides, and adiponectin. After a multivariable adjustment, the odds ratios for the second, third, and fourth quartiles of ox-LDL in metabolic syndrome compared with the lowest quartile were 1.76 (95% confidence interval [CI], 1.15-2.70), 2.45 (95% CI, 1.58-3.79), and 3.98 (95% CI, 2.52-6.28), respectively. LDL levels were not significantly associated with metabolic syndrome. Conclusions: Ox-LDL concentration was associated with metabolic syndrome in postmenopausal women. These findings suggest that high ox-LDL levels are associated with high cardiovascular risk in postmenopausal women with metabolic syndrome.

AB - Background: Low-density lipoprotein cholesterol (LDL-C) and oxidized low-density lipoprotein (ox-LDL) are probably associated with atherosclerosis and coronary artery disease. The influence of LDL-C and ox-LDL on metabolic syndrome among healthy, postmenopausal women has not been well studied. The aim of this study was to assess the association between LDL-C, ox-LDL, and metabolic syndrome in postmenopausal women. Methods: The study design was a cross-sectional study. A total of 1309 postmenopausal women (355 with metabolic syndrome and 954 without metabolic syndrome) aged 60-79. years were included. Lipid profiles, glucose, ox-LDL, adiponectin, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α concentrations were measured. Results: Plasma ox-LDL levels were higher in subjects with metabolic syndrome, when compared without metabolic syndrome subjects. A multiple linear regression analysis revealed that ox-LDL was significantly associated with high-density lipoprotein cholesterol, LDL-C, triglycerides, and adiponectin. After a multivariable adjustment, the odds ratios for the second, third, and fourth quartiles of ox-LDL in metabolic syndrome compared with the lowest quartile were 1.76 (95% confidence interval [CI], 1.15-2.70), 2.45 (95% CI, 1.58-3.79), and 3.98 (95% CI, 2.52-6.28), respectively. LDL levels were not significantly associated with metabolic syndrome. Conclusions: Ox-LDL concentration was associated with metabolic syndrome in postmenopausal women. These findings suggest that high ox-LDL levels are associated with high cardiovascular risk in postmenopausal women with metabolic syndrome.

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