Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease

Ji Young Hong, Sun Hee Jang, Song Yee Kim, Kyung Soo Chung, Joo Han Song, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Young Ae Kang

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Increased serum CA 19-9 levels in patients with nonmalignant diseases have been investigated in previous reports. This study evaluates the clinical significance of serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease and pulmonary tuberculosis. The median CA 19-9 level was higher in patients with pulmonary nontuberculous mycobacterial disease than in patients with pulmonary tuberculosis (pulmonary nontuberculous mycobacterial disease: 13.80, tuberculosis: 5.85, p < 0.001). A multivariate logistic regression analysis performed in this study showed that Mycobacterium abscessus (OR 9.97, 95% CI: 1.58, 62.80; p = 0.014) and active phase of pulmonary nontuberculous mycobacterial disease (OR 12.18, 95% CI: 1.07, 138.36, p = 0.044) were found to be risk factors for serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease. The serum CA 19-9 levels showed a tendency to decrease during successful treatment of pulmonary nontuberculous mycobacterial disease but not in pulmonary tuberculosis. These findings suggest that CA 19-9 may be a useful marker for monitoring therapeutic responses in pulmonary nontuberculous mycobacterial disease, although it is not pulmonary nontuberculous mycobacterial disease-specific marker.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalBrazilian Journal of Infectious Diseases
Volume20
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

Bibliographical note

Funding Information:
This work was supported by a National Research Foundation of Korea grant funded by the Korean Government ( 2011-0013018 ).

Publisher Copyright:
© 2015 Elsevier Editora Ltda.

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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