Abstract
Background and aims: White blood cell (WBC) count, a usual marker of systemic inflammation, is known to be associated with atherosclerotic cardiovascular disease. The aim of the present study was to determine the association of WBC count with arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). Methods and results: We examined the association between WBC count and baPWV in 788 Korean adults (375 men, 413 women) in a health examination program. The odds ratios for a high baPWV were calculated using multivariate logistic regression analysis after adjusting for confounding variables across WBC count quartiles (Q1: ≤5190, Q2: 5200-6080, Q3: 6090-7310, and Q4: ≥7320 cells/mm3). A high baPWV was defined as more than 1440 cm/s (>75th percentile). Age-adjusted baPWV mean values gradually increased with WBC quartiles (Q1 = 1294, Q2 = 1322, Q3 = 1347, and Q4 = 1367 cm/s). The odds ratios (95% CI) for a high baPWV in each WBC count quartile were 1.00, 1.34 (0.61-3.00), 2.20 (0.96-5.06), and 2.69 (1.15-6.47) after adjusting for age, sex, cigarette smoking, alcohol intake, regular exercise, body mass index (BMI), mean arterial blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, γ-glutamyltransferase (GGT), and uric acid. Conclusion: These findings indicate that elevated WBC count is associated with arterial stiffness. Accordingly, early detection of an elevated WBC count is important for arterial function and the assessment of cardiovascular risk.
| Original language | English |
|---|---|
| Pages (from-to) | 3-7 |
| Number of pages | 5 |
| Journal | Nutrition, Metabolism and Cardiovascular Diseases |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 Jan 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
- Cardiology and Cardiovascular Medicine
Cite this
}
Elevated white blood cell count is associated with arterial stiffness. / Lee, Yong Jae; Lee, Ji Won; Kim, Jong Koo; Lee, Jung Hyun; Kim, Jin Hyun; Kwon, Kil Young; Lee, Hye Ree; Lee, Duk Chul; Shim, Jae Yong.
In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 19, No. 1, 01.01.2009, p. 3-7.Research output: Contribution to journal › Article
TY - JOUR
T1 - Elevated white blood cell count is associated with arterial stiffness
AU - Lee, Yong Jae
AU - Lee, Ji Won
AU - Kim, Jong Koo
AU - Lee, Jung Hyun
AU - Kim, Jin Hyun
AU - Kwon, Kil Young
AU - Lee, Hye Ree
AU - Lee, Duk Chul
AU - Shim, Jae Yong
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Background and aims: White blood cell (WBC) count, a usual marker of systemic inflammation, is known to be associated with atherosclerotic cardiovascular disease. The aim of the present study was to determine the association of WBC count with arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). Methods and results: We examined the association between WBC count and baPWV in 788 Korean adults (375 men, 413 women) in a health examination program. The odds ratios for a high baPWV were calculated using multivariate logistic regression analysis after adjusting for confounding variables across WBC count quartiles (Q1: ≤5190, Q2: 5200-6080, Q3: 6090-7310, and Q4: ≥7320 cells/mm3). A high baPWV was defined as more than 1440 cm/s (>75th percentile). Age-adjusted baPWV mean values gradually increased with WBC quartiles (Q1 = 1294, Q2 = 1322, Q3 = 1347, and Q4 = 1367 cm/s). The odds ratios (95% CI) for a high baPWV in each WBC count quartile were 1.00, 1.34 (0.61-3.00), 2.20 (0.96-5.06), and 2.69 (1.15-6.47) after adjusting for age, sex, cigarette smoking, alcohol intake, regular exercise, body mass index (BMI), mean arterial blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, γ-glutamyltransferase (GGT), and uric acid. Conclusion: These findings indicate that elevated WBC count is associated with arterial stiffness. Accordingly, early detection of an elevated WBC count is important for arterial function and the assessment of cardiovascular risk.
AB - Background and aims: White blood cell (WBC) count, a usual marker of systemic inflammation, is known to be associated with atherosclerotic cardiovascular disease. The aim of the present study was to determine the association of WBC count with arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). Methods and results: We examined the association between WBC count and baPWV in 788 Korean adults (375 men, 413 women) in a health examination program. The odds ratios for a high baPWV were calculated using multivariate logistic regression analysis after adjusting for confounding variables across WBC count quartiles (Q1: ≤5190, Q2: 5200-6080, Q3: 6090-7310, and Q4: ≥7320 cells/mm3). A high baPWV was defined as more than 1440 cm/s (>75th percentile). Age-adjusted baPWV mean values gradually increased with WBC quartiles (Q1 = 1294, Q2 = 1322, Q3 = 1347, and Q4 = 1367 cm/s). The odds ratios (95% CI) for a high baPWV in each WBC count quartile were 1.00, 1.34 (0.61-3.00), 2.20 (0.96-5.06), and 2.69 (1.15-6.47) after adjusting for age, sex, cigarette smoking, alcohol intake, regular exercise, body mass index (BMI), mean arterial blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, γ-glutamyltransferase (GGT), and uric acid. Conclusion: These findings indicate that elevated WBC count is associated with arterial stiffness. Accordingly, early detection of an elevated WBC count is important for arterial function and the assessment of cardiovascular risk.
UR - http://www.scopus.com/inward/record.url?scp=58149203583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149203583&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2008.02.003
DO - 10.1016/j.numecd.2008.02.003
M3 - Article
C2 - 18456481
AN - SCOPUS:58149203583
VL - 19
SP - 3
EP - 7
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
IS - 1
ER -