Elevated white blood cell count is associated with arterial stiffness

Yong Jae Lee, Ji Won Lee, Jong Koo Kim, Jung Hyun Lee, Jin Hyun Kim, Kil Young Kwon, Hye Ree Lee, Duk Chul Lee, Jae Yong Shim

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background and aims: White blood cell (WBC) count, a usual marker of systemic inflammation, is known to be associated with atherosclerotic cardiovascular disease. The aim of the present study was to determine the association of WBC count with arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). Methods and results: We examined the association between WBC count and baPWV in 788 Korean adults (375 men, 413 women) in a health examination program. The odds ratios for a high baPWV were calculated using multivariate logistic regression analysis after adjusting for confounding variables across WBC count quartiles (Q1: ≤5190, Q2: 5200-6080, Q3: 6090-7310, and Q4: ≥7320 cells/mm3). A high baPWV was defined as more than 1440 cm/s (>75th percentile). Age-adjusted baPWV mean values gradually increased with WBC quartiles (Q1 = 1294, Q2 = 1322, Q3 = 1347, and Q4 = 1367 cm/s). The odds ratios (95% CI) for a high baPWV in each WBC count quartile were 1.00, 1.34 (0.61-3.00), 2.20 (0.96-5.06), and 2.69 (1.15-6.47) after adjusting for age, sex, cigarette smoking, alcohol intake, regular exercise, body mass index (BMI), mean arterial blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, γ-glutamyltransferase (GGT), and uric acid. Conclusion: These findings indicate that elevated WBC count is associated with arterial stiffness. Accordingly, early detection of an elevated WBC count is important for arterial function and the assessment of cardiovascular risk.

Original languageEnglish
Pages (from-to)3-7
Number of pages5
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume19
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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Vascular Stiffness
Pulse Wave Analysis
Leukocyte Count
Ankle
Arm
Arterial Pressure
Odds Ratio
Confounding Factors (Epidemiology)
Uric Acid
HDL Cholesterol
Fasting
Triglycerides
Body Mass Index
Leukocytes
Cardiovascular Diseases
Logistic Models
Smoking
Regression Analysis
Alcohols
Exercise

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

Lee, Yong Jae ; Lee, Ji Won ; Kim, Jong Koo ; Lee, Jung Hyun ; Kim, Jin Hyun ; Kwon, Kil Young ; Lee, Hye Ree ; Lee, Duk Chul ; Shim, Jae Yong. / Elevated white blood cell count is associated with arterial stiffness. In: Nutrition, Metabolism and Cardiovascular Diseases. 2009 ; Vol. 19, No. 1. pp. 3-7.
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abstract = "Background and aims: White blood cell (WBC) count, a usual marker of systemic inflammation, is known to be associated with atherosclerotic cardiovascular disease. The aim of the present study was to determine the association of WBC count with arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). Methods and results: We examined the association between WBC count and baPWV in 788 Korean adults (375 men, 413 women) in a health examination program. The odds ratios for a high baPWV were calculated using multivariate logistic regression analysis after adjusting for confounding variables across WBC count quartiles (Q1: ≤5190, Q2: 5200-6080, Q3: 6090-7310, and Q4: ≥7320 cells/mm3). A high baPWV was defined as more than 1440 cm/s (>75th percentile). Age-adjusted baPWV mean values gradually increased with WBC quartiles (Q1 = 1294, Q2 = 1322, Q3 = 1347, and Q4 = 1367 cm/s). The odds ratios (95{\%} CI) for a high baPWV in each WBC count quartile were 1.00, 1.34 (0.61-3.00), 2.20 (0.96-5.06), and 2.69 (1.15-6.47) after adjusting for age, sex, cigarette smoking, alcohol intake, regular exercise, body mass index (BMI), mean arterial blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, γ-glutamyltransferase (GGT), and uric acid. Conclusion: These findings indicate that elevated WBC count is associated with arterial stiffness. Accordingly, early detection of an elevated WBC count is important for arterial function and the assessment of cardiovascular risk.",
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Lee, YJ, Lee, JW, Kim, JK, Lee, JH, Kim, JH, Kwon, KY, Lee, HR, Lee, DC & Shim, JY 2009, 'Elevated white blood cell count is associated with arterial stiffness', Nutrition, Metabolism and Cardiovascular Diseases, vol. 19, no. 1, pp. 3-7. https://doi.org/10.1016/j.numecd.2008.02.003

Elevated white blood cell count is associated with arterial stiffness. / Lee, Yong Jae; Lee, Ji Won; Kim, Jong Koo; Lee, Jung Hyun; Kim, Jin Hyun; Kwon, Kil Young; Lee, Hye Ree; Lee, Duk Chul; Shim, Jae Yong.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 19, No. 1, 01.01.2009, p. 3-7.

Research output: Contribution to journalArticle

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T1 - Elevated white blood cell count is associated with arterial stiffness

AU - Lee, Yong Jae

AU - Lee, Ji Won

AU - Kim, Jong Koo

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AU - Lee, Duk Chul

AU - Shim, Jae Yong

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N2 - Background and aims: White blood cell (WBC) count, a usual marker of systemic inflammation, is known to be associated with atherosclerotic cardiovascular disease. The aim of the present study was to determine the association of WBC count with arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). Methods and results: We examined the association between WBC count and baPWV in 788 Korean adults (375 men, 413 women) in a health examination program. The odds ratios for a high baPWV were calculated using multivariate logistic regression analysis after adjusting for confounding variables across WBC count quartiles (Q1: ≤5190, Q2: 5200-6080, Q3: 6090-7310, and Q4: ≥7320 cells/mm3). A high baPWV was defined as more than 1440 cm/s (>75th percentile). Age-adjusted baPWV mean values gradually increased with WBC quartiles (Q1 = 1294, Q2 = 1322, Q3 = 1347, and Q4 = 1367 cm/s). The odds ratios (95% CI) for a high baPWV in each WBC count quartile were 1.00, 1.34 (0.61-3.00), 2.20 (0.96-5.06), and 2.69 (1.15-6.47) after adjusting for age, sex, cigarette smoking, alcohol intake, regular exercise, body mass index (BMI), mean arterial blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, γ-glutamyltransferase (GGT), and uric acid. Conclusion: These findings indicate that elevated WBC count is associated with arterial stiffness. Accordingly, early detection of an elevated WBC count is important for arterial function and the assessment of cardiovascular risk.

AB - Background and aims: White blood cell (WBC) count, a usual marker of systemic inflammation, is known to be associated with atherosclerotic cardiovascular disease. The aim of the present study was to determine the association of WBC count with arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). Methods and results: We examined the association between WBC count and baPWV in 788 Korean adults (375 men, 413 women) in a health examination program. The odds ratios for a high baPWV were calculated using multivariate logistic regression analysis after adjusting for confounding variables across WBC count quartiles (Q1: ≤5190, Q2: 5200-6080, Q3: 6090-7310, and Q4: ≥7320 cells/mm3). A high baPWV was defined as more than 1440 cm/s (>75th percentile). Age-adjusted baPWV mean values gradually increased with WBC quartiles (Q1 = 1294, Q2 = 1322, Q3 = 1347, and Q4 = 1367 cm/s). The odds ratios (95% CI) for a high baPWV in each WBC count quartile were 1.00, 1.34 (0.61-3.00), 2.20 (0.96-5.06), and 2.69 (1.15-6.47) after adjusting for age, sex, cigarette smoking, alcohol intake, regular exercise, body mass index (BMI), mean arterial blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, γ-glutamyltransferase (GGT), and uric acid. Conclusion: These findings indicate that elevated WBC count is associated with arterial stiffness. Accordingly, early detection of an elevated WBC count is important for arterial function and the assessment of cardiovascular risk.

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