Elimination of β-lactam antibiotics by UV irradiation, and the consequential changes in antibacterial activity

Yeon Jung Jung, Wan Gi Kim, Ko Woon Baek, Yun Young Hwang, Yeo Joon Yoon, Byung Soo Oh, Joon Wun Kang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This research was performed to assess the elimination of antibiotics and the consequential loss of antibacterial activity in water using UV irradiation. The target compounds were amoxicillin (AM), ampicillin (AP), cephradine (CP), and penicillin G (PG), which belong to the β-lactam class of antibiotics. Of the four antibiotics examined, cephradine possessed the greatest photolysis rate compared with the other three antibiotics. The quantum yield (φM) and molar adsorption coefficient (ε254) at 254 nm were determined with the direct photolysis kinetic model. The photo-product formation of the four antibiotics was observed by scanning and comparing UV spectra (200 < λ > 400 nm) of the aqueous solutions before and after UV photolysis. In addition, biological assay was performed to investigate the antibacterial activity of both the original substances and their degradation products, which accrue during UV irradiation. In the cases of amoxicillin and ampicillin, the antibacterial potential of their photo-products was observed at the concentrations examined. Consequently, occurrence of photo-byproducts of the two antibiotics necessitates detailed study on the potential risk to the actual environment.

Original languageEnglish
Title of host publicationWater Quality Technology Conference and Exposition 2008
Pages3511-3523
Number of pages13
Publication statusPublished - 2008 Dec 1
EventWater Quality Technology Conference and Exposition 2008 - Cincinnati, OH, United States
Duration: 2008 Nov 162008 Nov 20

Publication series

NameWater Quality Technology Conference and Exposition 2008

Other

OtherWater Quality Technology Conference and Exposition 2008
CountryUnited States
CityCincinnati, OH
Period08/11/1608/11/20

All Science Journal Classification (ASJC) codes

  • Safety, Risk, Reliability and Quality
  • Water Science and Technology
  • Geography, Planning and Development

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  • Cite this

    Jung, Y. J., Kim, W. G., Baek, K. W., Hwang, Y. Y., Yoon, Y. J., Oh, B. S., & Kang, J. W. (2008). Elimination of β-lactam antibiotics by UV irradiation, and the consequential changes in antibacterial activity. In Water Quality Technology Conference and Exposition 2008 (pp. 3511-3523). (Water Quality Technology Conference and Exposition 2008).