Elucidation of the strongest factors influencing rapid retinal nerve fiber layer thinning in glaucoma

Eun Ji Lee, Tae Woo Kim, Ji Ah Kim, Gyu Nam Kim, Joon Mo Kim, Michaël J.A. Girard, Jean Martial Mari, Hyunjoong Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

PURPOSE. To determine which groupings of prognostic factors best explain the rapid progressive retinal nerve fiber layer (RNFL) thinning in patients with primary open-angle glaucoma (POAG). METHODS. Optic nerves of 111 POAG patients who were followed for at least 2.5 years, during which the RNFL thickness was measured by serial spectral-domain optical coherence tomography (OCT) were included. Eyes were imaged using enhanced depth-imaging spectraldomain OCT and swept-source OCT angiography to determine the lamina cribrosa curvature index (LCCI), and the presence of a choroidal microvasculature dropout (cMvD), respectively. The rate of RNFL thinning was determined by linear regression of serial OCT RNFL thickness measurements. A regression tree model was used to find groupings of factors that best explain the rate of future RNFL thinning. RESULTS. Disc hemorrhage, larger LCCI, and presence of cMvD were associated with faster global RNFL thinning in the multivariate regression analysis. The regression tree analysis revealed three stratified groups based on the rate of RNFL thinning, divided by the LCCI and the presence of cMvD. Eyes with LCCI ≥11.87 had the fastest RNFL thinning (2.4 ± 0.8 lm/ year, mean ± SD). Among eyes with LCCI <11.87, the presence of cMvD was the strongest factor influencing faster RNFL thinning (1.5 ± 0.8 lm/year). Eyes with LCCI <11.87 and without a cMvD exhibited the slowest RNFL thinning (0.8 ± 0.9 lm/year). CONCLUSIONS. Our regression tree model demonstrated that larger LCCI, and then the presence of cMvD were the first and second strongest prognostic factors for faster progressive RNFL thinning. Further studies may be needed to confirm these findings.

Original languageEnglish
Pages (from-to)3343-3351
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Volume60
Issue number10
DOIs
Publication statusPublished - 2019 Aug

Fingerprint

Nerve Fibers
Glaucoma
Microvessels
Optical Coherence Tomography
Regression Analysis
Optic Nerve
Linear Models
Angiography
Multivariate Analysis
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Lee, Eun Ji ; Kim, Tae Woo ; Kim, Ji Ah ; Kim, Gyu Nam ; Kim, Joon Mo ; Girard, Michaël J.A. ; Mari, Jean Martial ; Kim, Hyunjoong. / Elucidation of the strongest factors influencing rapid retinal nerve fiber layer thinning in glaucoma. In: Investigative Ophthalmology and Visual Science. 2019 ; Vol. 60, No. 10. pp. 3343-3351.
@article{6b36e0d88ff94d9888c22f06cee0faab,
title = "Elucidation of the strongest factors influencing rapid retinal nerve fiber layer thinning in glaucoma",
abstract = "PURPOSE. To determine which groupings of prognostic factors best explain the rapid progressive retinal nerve fiber layer (RNFL) thinning in patients with primary open-angle glaucoma (POAG). METHODS. Optic nerves of 111 POAG patients who were followed for at least 2.5 years, during which the RNFL thickness was measured by serial spectral-domain optical coherence tomography (OCT) were included. Eyes were imaged using enhanced depth-imaging spectraldomain OCT and swept-source OCT angiography to determine the lamina cribrosa curvature index (LCCI), and the presence of a choroidal microvasculature dropout (cMvD), respectively. The rate of RNFL thinning was determined by linear regression of serial OCT RNFL thickness measurements. A regression tree model was used to find groupings of factors that best explain the rate of future RNFL thinning. RESULTS. Disc hemorrhage, larger LCCI, and presence of cMvD were associated with faster global RNFL thinning in the multivariate regression analysis. The regression tree analysis revealed three stratified groups based on the rate of RNFL thinning, divided by the LCCI and the presence of cMvD. Eyes with LCCI ≥11.87 had the fastest RNFL thinning (2.4 ± 0.8 lm/ year, mean ± SD). Among eyes with LCCI <11.87, the presence of cMvD was the strongest factor influencing faster RNFL thinning (1.5 ± 0.8 lm/year). Eyes with LCCI <11.87 and without a cMvD exhibited the slowest RNFL thinning (0.8 ± 0.9 lm/year). CONCLUSIONS. Our regression tree model demonstrated that larger LCCI, and then the presence of cMvD were the first and second strongest prognostic factors for faster progressive RNFL thinning. Further studies may be needed to confirm these findings.",
author = "Lee, {Eun Ji} and Kim, {Tae Woo} and Kim, {Ji Ah} and Kim, {Gyu Nam} and Kim, {Joon Mo} and Girard, {Micha{\"e}l J.A.} and Mari, {Jean Martial} and Hyunjoong Kim",
year = "2019",
month = "8",
doi = "10.1167/iovs.18-26519",
language = "English",
volume = "60",
pages = "3343--3351",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "10",

}

Elucidation of the strongest factors influencing rapid retinal nerve fiber layer thinning in glaucoma. / Lee, Eun Ji; Kim, Tae Woo; Kim, Ji Ah; Kim, Gyu Nam; Kim, Joon Mo; Girard, Michaël J.A.; Mari, Jean Martial; Kim, Hyunjoong.

In: Investigative Ophthalmology and Visual Science, Vol. 60, No. 10, 08.2019, p. 3343-3351.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Elucidation of the strongest factors influencing rapid retinal nerve fiber layer thinning in glaucoma

AU - Lee, Eun Ji

AU - Kim, Tae Woo

AU - Kim, Ji Ah

AU - Kim, Gyu Nam

AU - Kim, Joon Mo

AU - Girard, Michaël J.A.

AU - Mari, Jean Martial

AU - Kim, Hyunjoong

PY - 2019/8

Y1 - 2019/8

N2 - PURPOSE. To determine which groupings of prognostic factors best explain the rapid progressive retinal nerve fiber layer (RNFL) thinning in patients with primary open-angle glaucoma (POAG). METHODS. Optic nerves of 111 POAG patients who were followed for at least 2.5 years, during which the RNFL thickness was measured by serial spectral-domain optical coherence tomography (OCT) were included. Eyes were imaged using enhanced depth-imaging spectraldomain OCT and swept-source OCT angiography to determine the lamina cribrosa curvature index (LCCI), and the presence of a choroidal microvasculature dropout (cMvD), respectively. The rate of RNFL thinning was determined by linear regression of serial OCT RNFL thickness measurements. A regression tree model was used to find groupings of factors that best explain the rate of future RNFL thinning. RESULTS. Disc hemorrhage, larger LCCI, and presence of cMvD were associated with faster global RNFL thinning in the multivariate regression analysis. The regression tree analysis revealed three stratified groups based on the rate of RNFL thinning, divided by the LCCI and the presence of cMvD. Eyes with LCCI ≥11.87 had the fastest RNFL thinning (2.4 ± 0.8 lm/ year, mean ± SD). Among eyes with LCCI <11.87, the presence of cMvD was the strongest factor influencing faster RNFL thinning (1.5 ± 0.8 lm/year). Eyes with LCCI <11.87 and without a cMvD exhibited the slowest RNFL thinning (0.8 ± 0.9 lm/year). CONCLUSIONS. Our regression tree model demonstrated that larger LCCI, and then the presence of cMvD were the first and second strongest prognostic factors for faster progressive RNFL thinning. Further studies may be needed to confirm these findings.

AB - PURPOSE. To determine which groupings of prognostic factors best explain the rapid progressive retinal nerve fiber layer (RNFL) thinning in patients with primary open-angle glaucoma (POAG). METHODS. Optic nerves of 111 POAG patients who were followed for at least 2.5 years, during which the RNFL thickness was measured by serial spectral-domain optical coherence tomography (OCT) were included. Eyes were imaged using enhanced depth-imaging spectraldomain OCT and swept-source OCT angiography to determine the lamina cribrosa curvature index (LCCI), and the presence of a choroidal microvasculature dropout (cMvD), respectively. The rate of RNFL thinning was determined by linear regression of serial OCT RNFL thickness measurements. A regression tree model was used to find groupings of factors that best explain the rate of future RNFL thinning. RESULTS. Disc hemorrhage, larger LCCI, and presence of cMvD were associated with faster global RNFL thinning in the multivariate regression analysis. The regression tree analysis revealed three stratified groups based on the rate of RNFL thinning, divided by the LCCI and the presence of cMvD. Eyes with LCCI ≥11.87 had the fastest RNFL thinning (2.4 ± 0.8 lm/ year, mean ± SD). Among eyes with LCCI <11.87, the presence of cMvD was the strongest factor influencing faster RNFL thinning (1.5 ± 0.8 lm/year). Eyes with LCCI <11.87 and without a cMvD exhibited the slowest RNFL thinning (0.8 ± 0.9 lm/year). CONCLUSIONS. Our regression tree model demonstrated that larger LCCI, and then the presence of cMvD were the first and second strongest prognostic factors for faster progressive RNFL thinning. Further studies may be needed to confirm these findings.

UR - http://www.scopus.com/inward/record.url?scp=85070702592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070702592&partnerID=8YFLogxK

U2 - 10.1167/iovs.18-26519

DO - 10.1167/iovs.18-26519

M3 - Article

C2 - 31370062

AN - SCOPUS:85070702592

VL - 60

SP - 3343

EP - 3351

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 10

ER -