Emergence and wide dissemination of CTX-M-type ESBLs, and CMY-2- And DHA-1-type AmpC β-lactamases in Korean respiratory isolates of Klebsiella pneumoniae

Hwa Yum Jong, Shinyoung Kim, Hyukmin Lee, Dongeun Yong, Kyungwon Lee, Sang Nae Cho, Yunsop Chong

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24 Citations (Scopus)

Abstract

Respiratory isolates of Klebsiella pneumoniae in Korea during 2002-2003 were studied to determine the prevalence and types of extended-spectrum β-lactamases (ESBLs) and plasmid-mediated AmpC β-lactamases (PABLs). ESBL-production was tested by double-disk synergy, and genotypes of β-lactamases were determined by PCR and sequencing. ESBLs were detected in 28.4% of 373 isolates, and the most prevalent types were SHV-12 (63 isolates) and CTX-M-14 (9 isolates). Forty of 75 ESBL-producers (53.5%) also had PABLs: 21 isolates with CMY-2-like, 17 with DHA-1-like. Pulsed-field gel electrophoresis showed 19 types and 25 of 74 isolates had an identical pattern, indicating nosocomial spread. Dissemination of ESBL- and PABL-producing K. pneumoniae strains in Korea is a particular concern, as it limits the choice of antimicrobial agents for treatment of infections.

Original languageEnglish
Pages (from-to)961-965
Number of pages5
JournalJournal of Korean medical science
Volume20
Issue number6
DOIs
Publication statusPublished - 2005 Dec

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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