Emerging concepts of motor reserve in Parkinson’s disease

Seok Jong Chung, Jae Jung Lee, Phil Hyu Lee, Young H. Sohn

Research output: Contribution to journalArticlepeer-review

Abstract

The concept of cognitive reserve (CR) in Alzheimer’s disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. An enhanced CR may lead to less cognitive deficits despite severe pathological lesions. Parkinson’s disease (PD) is also a common neurodegenerative disease and is mainly characterized by motor dysfunction related to striatal dopaminergic depletion. The degree of motor deficits in PD is closely correlated to the degree of dopamine depletion; however, significant individual variations still exist. Therefore, we hypothesized that the presence of motor reserve (MR) in PD explains the individual differences in motor deficits despite similar levels of striatal dopamine depletion. Since 2015, we have performed a series of studies investigating MR in de novo patients with PD using the data of initial clinical presentation and dopamine transporter PET scan. In this review, we summarized the results of these published studies. In particular, some premorbid experiences (i.e., physical activity and education) and modifiable factors (i.e., body mass index and white matter hyperintensity on brain image studies) could modulate an individual’s capacity to tolerate PD pathology, which can be maintained throughout disease progression.

Original languageEnglish
Pages (from-to)171-184
Number of pages14
JournalJournal of Movement Disorders
Volume13
Issue number3
DOIs
Publication statusPublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 The Korean Movement Disorder Society.

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neurology

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