Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem

Hyun Woo Park, Si Young Cho, Hyun Hee Kim, Bong Sik Yun, Jeong Un Kim, Sang Jun Lee, Jiyong Park

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Syringaresinol exists either exclusively as one enantiomer or enantiomeric mixtures in plant foods. We found that (+)-syringaresinol, but not (-)-syringaresinol, upregulates silent information regulator two ortholog 1 (SIRT1) gene expression, and thus, Panax ginseng berry with predominantly high contents of (+)-syringaresinol exhibits higher activity in inducing SIRT1 gene expression than Acanthopanax senticosus Harms stem with almost equal proportion of the two enantiomers. These findings highlight the importance of the absolute configuration of syringaresinol for the biological activity.

Original languageEnglish
Pages (from-to)307-309
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number2
DOIs
Publication statusPublished - 2015 Jan 15

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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