End-stage renal disease impairs the multidirectional movements of the common carotid artery: Assessment using dimensional speckle-tracking carotid strain ultrasonography

Sang Eun Lee, Jinyong Lee, Tae Hyun Yoo, In Jeong Cho, Hyuk Jae Chang

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Arterial stiffening is a major contributing factor in the development of cardiovascular disease in patients with end-stage renal disease (ESRD). However, there is no gold standard for evaluating arterial stiffness. This study aimed to evaluate the newly developed speckle-tracking carotid strain imaging method in assessing arterial stiffness in patients with ESRD. METHODS: In total, 85 patients with normal renal function (controls) and 36 with ESRD were enrolled in this single-center study. Carotid B-mode ultrasonography was performed for all patients. Arterial stiffness indices and strain parameters of the common carotid arteries were analyzed. Values were compared between the groups, and multivariate linear regression analysis was performed to assess the impact of ESRD on carotid strain. RESULTS: There were no differences in the intima-media thickness, β stiffness index, and arterial compliance, but arterial distensibility was lower, and the elastic modulus and pulse wave velocity β (PWV) were higher among patients with ESRD (all p < 0.05), whether assessed in the longitudinal or transverse plane. Both longitudinal and transverse strain rates were reduced in patients with ESRD (all p < 0.05). In multivariate analyses, ESRD independently reduced both transverse radial strain and strain rate (all p < 0.05), and the transverse circumferential strain and strain rate (p < 0.05). However, all conventional aortic stiffness indices and longitudinal strain parameters were not associated with ESRD. CONCLUSIONS: Speckle-tracking carotid strain ultrasonography was successfully performed in both normal subjects and patients with ESRD. Multidirectional carotid strain analyses may provide more value than conventional aortic stiffness indices for risk stratification in patients with ESRD.

Original languageEnglish
Pages (from-to)155-164
Number of pages10
JournalJournal of Cardiovascular Imaging
Volume26
Issue number3
DOIs
Publication statusPublished - 2018 Sep

Bibliographical note

Funding Information:
This work was supported by the Technology Innovation Program (10052749, Development of ultrafast cardiovascular diagnostic system based on the multifunctional 3D ultrasound imaging) funded by the Ministry of Trade, Industry and Energy (MOTIE) of Korea.

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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