Endoscopic disconnection for hypothalamic hamartoma with intractable seizure: Report of four cases

Joong Uhn Choi, Kook Hee Yang, Tae Gon Kim, Jong Hee Chang, Jin Woo Chang, Byung In Lee, Dong Seok Kim

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Although intractable epilepsy associated with hypothalamic hamartoma (HH) can be controlled by microsurgical resection of the lesion, excision of deep-seated lesions is often associated with morbidity and mortality. Endoscopic disconnection is less invasive and seems to be well suited for this indication. The authors discuss the role of endoscopic-assisted surgery in the management of HH-induced seizures. Four patients with HH-related intractable gelastic seizure underwent endoscopic disconnection surgery. Postoperatively, all patients exhibited improvement. Two patients became seizure free immediately after endoscopic disconnection surgery, one patient with a widespread seizure focus involving the motor strip continued to experience rare complex partial seizures but gelastic seizures ceased, and one experienced a reduced frequency of seizures but persistence of some generalized seizures. Three patients suffered postoperative disconnection-like syndrome, which continued 3 to 7 days and spontaneously disappeared. The authors advocate the endoscopic disconnection surgery as a safe and effective treatment for HH-related epilepsy by blocking the spread of epileptic discharges from the lesion.

Original languageEnglish
Pages (from-to)506-511
Number of pages6
JournalJournal of neurosurgery
Volume100
Issue number5 SUPPL.
Publication statusPublished - 2004 May 1

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Seizures
Laughter
Hypothalamic hamartomas
Motor Cortex
Epilepsy
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Choi, J. U., Yang, K. H., Kim, T. G., Chang, J. H., Chang, J. W., Lee, B. I., & Kim, D. S. (2004). Endoscopic disconnection for hypothalamic hamartoma with intractable seizure: Report of four cases. Journal of neurosurgery, 100(5 SUPPL.), 506-511.
Choi, Joong Uhn ; Yang, Kook Hee ; Kim, Tae Gon ; Chang, Jong Hee ; Chang, Jin Woo ; Lee, Byung In ; Kim, Dong Seok. / Endoscopic disconnection for hypothalamic hamartoma with intractable seizure : Report of four cases. In: Journal of neurosurgery. 2004 ; Vol. 100, No. 5 SUPPL. pp. 506-511.
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Choi, JU, Yang, KH, Kim, TG, Chang, JH, Chang, JW, Lee, BI & Kim, DS 2004, 'Endoscopic disconnection for hypothalamic hamartoma with intractable seizure: Report of four cases', Journal of neurosurgery, vol. 100, no. 5 SUPPL., pp. 506-511.

Endoscopic disconnection for hypothalamic hamartoma with intractable seizure : Report of four cases. / Choi, Joong Uhn; Yang, Kook Hee; Kim, Tae Gon; Chang, Jong Hee; Chang, Jin Woo; Lee, Byung In; Kim, Dong Seok.

In: Journal of neurosurgery, Vol. 100, No. 5 SUPPL., 01.05.2004, p. 506-511.

Research output: Contribution to journalArticle

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