Endoscopic disconnection for hypothalamic hamartoma with intractable seizure

Report of four cases

Joong Uhn Choi, Kook Hee Yang, Tae Gon Kim, Jong Hee Chang, JinWoo Chang, Byung In Lee, Dong Seok Kim

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Although intractable epilepsy associated with hypothalamic hamartoma (HH) can be controlled by microsurgical resection of the lesion, excision of deep-seated lesions is often associated with morbidity and mortality. Endoscopic disconnection is less invasive and seems to be well suited for this indication. The authors discuss the role of endoscopic-assisted surgery in the management of HH-induced seizures. Four patients with HH-related intractable gelastic seizure underwent endoscopic disconnection surgery. Postoperatively, all patients exhibited improvement. Two patients became seizure free immediately after endoscopic disconnection surgery, one patient with a widespread seizure focus involving the motor strip continued to experience rare complex partial seizures but gelastic seizures ceased, and one experienced a reduced frequency of seizures but persistence of some generalized seizures. Three patients suffered postoperative disconnection-like syndrome, which continued 3 to 7 days and spontaneously disappeared. The authors advocate the endoscopic disconnection surgery as a safe and effective treatment for HH-related epilepsy by blocking the spread of epileptic discharges from the lesion.

Original languageEnglish
Pages (from-to)506-511
Number of pages6
JournalJournal of Neurosurgery
Volume100
Issue number5 SUPPL.
Publication statusPublished - 2004 May 1

Fingerprint

Seizures
Laughter
Hypothalamic hamartomas
Motor Cortex
Epilepsy
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Choi, J. U., Yang, K. H., Kim, T. G., Chang, J. H., Chang, J., Lee, B. I., & Kim, D. S. (2004). Endoscopic disconnection for hypothalamic hamartoma with intractable seizure: Report of four cases. Journal of Neurosurgery, 100(5 SUPPL.), 506-511.
Choi, Joong Uhn ; Yang, Kook Hee ; Kim, Tae Gon ; Chang, Jong Hee ; Chang, JinWoo ; Lee, Byung In ; Kim, Dong Seok. / Endoscopic disconnection for hypothalamic hamartoma with intractable seizure : Report of four cases. In: Journal of Neurosurgery. 2004 ; Vol. 100, No. 5 SUPPL. pp. 506-511.
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Choi, JU, Yang, KH, Kim, TG, Chang, JH, Chang, J, Lee, BI & Kim, DS 2004, 'Endoscopic disconnection for hypothalamic hamartoma with intractable seizure: Report of four cases', Journal of Neurosurgery, vol. 100, no. 5 SUPPL., pp. 506-511.

Endoscopic disconnection for hypothalamic hamartoma with intractable seizure : Report of four cases. / Choi, Joong Uhn; Yang, Kook Hee; Kim, Tae Gon; Chang, Jong Hee; Chang, JinWoo; Lee, Byung In; Kim, Dong Seok.

In: Journal of Neurosurgery, Vol. 100, No. 5 SUPPL., 01.05.2004, p. 506-511.

Research output: Contribution to journalArticle

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Choi JU, Yang KH, Kim TG, Chang JH, Chang J, Lee BI et al. Endoscopic disconnection for hypothalamic hamartoma with intractable seizure: Report of four cases. Journal of Neurosurgery. 2004 May 1;100(5 SUPPL.):506-511.