Endoscopic resection for duodenal carcinoid tumors: A multicenter, retrospective study

Korean College of Helicobacter and Upper Gastrointestinal Research

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background and Aim: Gastrointestinal carcinoid tumors <10mm in diameter and limited to the submucosal layer demonstrate a low frequency of lymph node and distant metastasis, and are suitable for endoscopic treatment. The aim of this study was to assess the efficacy, safety, and long-term prognosis of endoscopic resections for the treatment of duodenal carcinoid tumors. Methods: This study included a total of 41 duodenal carcinoid tumors in 38 patients between January 2006 and December 2011. The indications for endoscopic resection were lesions ≤10mm in diameter, confined to the submucosal layer, and without lymph node or distant metastasis. Endoscopic resection was accomplished using endoscopic mucosal resection (EMR), EMR with a ligation device (EMR-L), EMR after circumferential precutting, or endoscopic submucosal dissection (ESD). Results: EMR was performed in 18 tumors, EMR-L in 16, EMR after circumferential precutting in 3, and ESD in 4. En-bloc resection was performed in 39 tumors (95%), and endoscopic complete resection was achieved in 40 (98%); pathological complete resection was achieved in 17 tumors (41%). The endoscopic complete resection rate did not differ according to the resection method, but the pathological complete resection rate was higher for ESD than for EMR and EMR-L. Intraprocedural bleeding was noted in five cases, with no occurrence of perforation. Recurrence was not observed during the mean follow-up period of 17 months (range 1-53 months). Conclusion: Endoscopic resection appears to be a safe and effective treatment for duodenal carcinoid tumors measuring ≤10mm in diameter and confined to the submucosal layer.

Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume29
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1

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Carcinoid Tumor
Multicenter Studies
Retrospective Studies
Endoscopic Mucosal Resection
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Ligation
Therapeutics
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Korean College of Helicobacter and Upper Gastrointestinal Research. / Endoscopic resection for duodenal carcinoid tumors : A multicenter, retrospective study. In: Journal of Gastroenterology and Hepatology (Australia). 2014 ; Vol. 29, No. 2. pp. 318-324.
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abstract = "Background and Aim: Gastrointestinal carcinoid tumors <10mm in diameter and limited to the submucosal layer demonstrate a low frequency of lymph node and distant metastasis, and are suitable for endoscopic treatment. The aim of this study was to assess the efficacy, safety, and long-term prognosis of endoscopic resections for the treatment of duodenal carcinoid tumors. Methods: This study included a total of 41 duodenal carcinoid tumors in 38 patients between January 2006 and December 2011. The indications for endoscopic resection were lesions ≤10mm in diameter, confined to the submucosal layer, and without lymph node or distant metastasis. Endoscopic resection was accomplished using endoscopic mucosal resection (EMR), EMR with a ligation device (EMR-L), EMR after circumferential precutting, or endoscopic submucosal dissection (ESD). Results: EMR was performed in 18 tumors, EMR-L in 16, EMR after circumferential precutting in 3, and ESD in 4. En-bloc resection was performed in 39 tumors (95{\%}), and endoscopic complete resection was achieved in 40 (98{\%}); pathological complete resection was achieved in 17 tumors (41{\%}). The endoscopic complete resection rate did not differ according to the resection method, but the pathological complete resection rate was higher for ESD than for EMR and EMR-L. Intraprocedural bleeding was noted in five cases, with no occurrence of perforation. Recurrence was not observed during the mean follow-up period of 17 months (range 1-53 months). Conclusion: Endoscopic resection appears to be a safe and effective treatment for duodenal carcinoid tumors measuring ≤10mm in diameter and confined to the submucosal layer.",
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Endoscopic resection for duodenal carcinoid tumors : A multicenter, retrospective study. / Korean College of Helicobacter and Upper Gastrointestinal Research.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 29, No. 2, 01.02.2014, p. 318-324.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Endoscopic resection for duodenal carcinoid tumors

T2 - A multicenter, retrospective study

AU - Korean College of Helicobacter and Upper Gastrointestinal Research

AU - Kim, Gwang Ha

AU - Kim, Jin Il

AU - Jeon, Seong Woo

AU - Moon, Jeong Seop

AU - Chung, Il Kwun

AU - Jee, Sam Ryong

AU - Kim, Heung Up

AU - Seo, Geom Seog

AU - Baik, Gwang Ho

AU - Lee, Yong Chan

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Background and Aim: Gastrointestinal carcinoid tumors <10mm in diameter and limited to the submucosal layer demonstrate a low frequency of lymph node and distant metastasis, and are suitable for endoscopic treatment. The aim of this study was to assess the efficacy, safety, and long-term prognosis of endoscopic resections for the treatment of duodenal carcinoid tumors. Methods: This study included a total of 41 duodenal carcinoid tumors in 38 patients between January 2006 and December 2011. The indications for endoscopic resection were lesions ≤10mm in diameter, confined to the submucosal layer, and without lymph node or distant metastasis. Endoscopic resection was accomplished using endoscopic mucosal resection (EMR), EMR with a ligation device (EMR-L), EMR after circumferential precutting, or endoscopic submucosal dissection (ESD). Results: EMR was performed in 18 tumors, EMR-L in 16, EMR after circumferential precutting in 3, and ESD in 4. En-bloc resection was performed in 39 tumors (95%), and endoscopic complete resection was achieved in 40 (98%); pathological complete resection was achieved in 17 tumors (41%). The endoscopic complete resection rate did not differ according to the resection method, but the pathological complete resection rate was higher for ESD than for EMR and EMR-L. Intraprocedural bleeding was noted in five cases, with no occurrence of perforation. Recurrence was not observed during the mean follow-up period of 17 months (range 1-53 months). Conclusion: Endoscopic resection appears to be a safe and effective treatment for duodenal carcinoid tumors measuring ≤10mm in diameter and confined to the submucosal layer.

AB - Background and Aim: Gastrointestinal carcinoid tumors <10mm in diameter and limited to the submucosal layer demonstrate a low frequency of lymph node and distant metastasis, and are suitable for endoscopic treatment. The aim of this study was to assess the efficacy, safety, and long-term prognosis of endoscopic resections for the treatment of duodenal carcinoid tumors. Methods: This study included a total of 41 duodenal carcinoid tumors in 38 patients between January 2006 and December 2011. The indications for endoscopic resection were lesions ≤10mm in diameter, confined to the submucosal layer, and without lymph node or distant metastasis. Endoscopic resection was accomplished using endoscopic mucosal resection (EMR), EMR with a ligation device (EMR-L), EMR after circumferential precutting, or endoscopic submucosal dissection (ESD). Results: EMR was performed in 18 tumors, EMR-L in 16, EMR after circumferential precutting in 3, and ESD in 4. En-bloc resection was performed in 39 tumors (95%), and endoscopic complete resection was achieved in 40 (98%); pathological complete resection was achieved in 17 tumors (41%). The endoscopic complete resection rate did not differ according to the resection method, but the pathological complete resection rate was higher for ESD than for EMR and EMR-L. Intraprocedural bleeding was noted in five cases, with no occurrence of perforation. Recurrence was not observed during the mean follow-up period of 17 months (range 1-53 months). Conclusion: Endoscopic resection appears to be a safe and effective treatment for duodenal carcinoid tumors measuring ≤10mm in diameter and confined to the submucosal layer.

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DO - 10.1111/jgh.12390

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