Abstract
Background and Objective: Endoscopic resection (ER) has become an important curative option for early gastric cancer (EGC). However, the application of ER for undifferentiated EGC remains controversial. The aim of this study was to evaluate the clinicopathologic outcomes of ER performed in undifferentiated EGC with special reference to histopathologic subtypes to examine the feasibility of ER in undifferentiated EGC. Design and Setting: Retrospective, single-center study. Patients: From January 2001 to April 2007, 58 lesions in 58 patients with undifferentiated EGC (17 poorly differentiated adenocarcinoma; 41 signet-ring cell carcinoma) were treated by ER at Severance Hospital, Seoul, Korea. Main Outcome Measurements: The therapeutic efficacy of ER was assessed according to en bloc resection, histologic complete resection (CR), lateral or vertical cut end-positive (including submucosal invasion), and recurrence rates in 3- to 65-month follow-up periods. Results: The en bloc resection and CR rates were 84.5% and 67.2%, respectively. The en bloc and CR rates in poorly differentiated were 82.4% and 58.8%, whereas those in signet-ring cell were 85.4% and 70.7%, respectively. There were no significant differences between poorly differentiated and signet-ring cell. However, all (100%) of the histologic incomplete resections in poorly differentiated were vertical cut end-positive, whereas 83.3% of these resections in signet-ring cell were lateral cut end-positive. The recurrence rate was 5.1% in CR during the follow-up period. Limitations: Retrospective, short-term follow-up period. Conclusions: ER may be a feasible local treatment for undifferentiated EGC if CR can be achieved. However, a different approach is necessary between poorly differentiated and signet-ring cell before ER to prevent incomplete resection.
| Original language | English |
|---|---|
| Pages (from-to) | e1-e9 |
| Journal | Gastrointestinal Endoscopy |
| Volume | 69 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2009 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Gastroenterology
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Endoscopic resection for undifferentiated early gastric cancer. / Kim, Jie Hyun; Lee, Yong Chan; Kim, Hyunki; Song, Kyung Ho; Lee, Sang Kil; Cheon, Jae Hee; Kim, Hoguen; Hyung, Woo Jin; Noh, Sung Hoon; Kim, Choong Bai; Chung, Jae Bock.
In: Gastrointestinal Endoscopy, Vol. 69, No. 4, 01.04.2009, p. e1-e9.Research output: Contribution to journal › Article
TY - JOUR
T1 - Endoscopic resection for undifferentiated early gastric cancer
AU - Kim, Jie Hyun
AU - Lee, Yong Chan
AU - Kim, Hyunki
AU - Song, Kyung Ho
AU - Lee, Sang Kil
AU - Cheon, Jae Hee
AU - Kim, Hoguen
AU - Hyung, Woo Jin
AU - Noh, Sung Hoon
AU - Kim, Choong Bai
AU - Chung, Jae Bock
PY - 2009/4/1
Y1 - 2009/4/1
N2 - Background and Objective: Endoscopic resection (ER) has become an important curative option for early gastric cancer (EGC). However, the application of ER for undifferentiated EGC remains controversial. The aim of this study was to evaluate the clinicopathologic outcomes of ER performed in undifferentiated EGC with special reference to histopathologic subtypes to examine the feasibility of ER in undifferentiated EGC. Design and Setting: Retrospective, single-center study. Patients: From January 2001 to April 2007, 58 lesions in 58 patients with undifferentiated EGC (17 poorly differentiated adenocarcinoma; 41 signet-ring cell carcinoma) were treated by ER at Severance Hospital, Seoul, Korea. Main Outcome Measurements: The therapeutic efficacy of ER was assessed according to en bloc resection, histologic complete resection (CR), lateral or vertical cut end-positive (including submucosal invasion), and recurrence rates in 3- to 65-month follow-up periods. Results: The en bloc resection and CR rates were 84.5% and 67.2%, respectively. The en bloc and CR rates in poorly differentiated were 82.4% and 58.8%, whereas those in signet-ring cell were 85.4% and 70.7%, respectively. There were no significant differences between poorly differentiated and signet-ring cell. However, all (100%) of the histologic incomplete resections in poorly differentiated were vertical cut end-positive, whereas 83.3% of these resections in signet-ring cell were lateral cut end-positive. The recurrence rate was 5.1% in CR during the follow-up period. Limitations: Retrospective, short-term follow-up period. Conclusions: ER may be a feasible local treatment for undifferentiated EGC if CR can be achieved. However, a different approach is necessary between poorly differentiated and signet-ring cell before ER to prevent incomplete resection.
AB - Background and Objective: Endoscopic resection (ER) has become an important curative option for early gastric cancer (EGC). However, the application of ER for undifferentiated EGC remains controversial. The aim of this study was to evaluate the clinicopathologic outcomes of ER performed in undifferentiated EGC with special reference to histopathologic subtypes to examine the feasibility of ER in undifferentiated EGC. Design and Setting: Retrospective, single-center study. Patients: From January 2001 to April 2007, 58 lesions in 58 patients with undifferentiated EGC (17 poorly differentiated adenocarcinoma; 41 signet-ring cell carcinoma) were treated by ER at Severance Hospital, Seoul, Korea. Main Outcome Measurements: The therapeutic efficacy of ER was assessed according to en bloc resection, histologic complete resection (CR), lateral or vertical cut end-positive (including submucosal invasion), and recurrence rates in 3- to 65-month follow-up periods. Results: The en bloc resection and CR rates were 84.5% and 67.2%, respectively. The en bloc and CR rates in poorly differentiated were 82.4% and 58.8%, whereas those in signet-ring cell were 85.4% and 70.7%, respectively. There were no significant differences between poorly differentiated and signet-ring cell. However, all (100%) of the histologic incomplete resections in poorly differentiated were vertical cut end-positive, whereas 83.3% of these resections in signet-ring cell were lateral cut end-positive. The recurrence rate was 5.1% in CR during the follow-up period. Limitations: Retrospective, short-term follow-up period. Conclusions: ER may be a feasible local treatment for undifferentiated EGC if CR can be achieved. However, a different approach is necessary between poorly differentiated and signet-ring cell before ER to prevent incomplete resection.
UR - http://www.scopus.com/inward/record.url?scp=62949200528&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62949200528&partnerID=8YFLogxK
U2 - 10.1016/j.gie.2008.10.040
DO - 10.1016/j.gie.2008.10.040
M3 - Article
C2 - 19327466
AN - SCOPUS:62949200528
VL - 69
SP - e1-e9
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
SN - 0016-5107
IS - 4
ER -