Endothelial dysfunction and hyperhomocysteinemia in Parkinson's disease: Flow-mediated dilation study

Jung Han Yoon, Jin Soo Lee, Seok Woo Yong, Ji Man Hong, philhyu Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Levodopa (l-dopa) therapy in Parkinson's disease (PD) increases serum homocysteine levels because of its metabolism via catechol O-methyltransferase, which may lead to endothelial dysfunction. Method: We enrolled 40 PD patients treated with l-dopa, 33 PD patients treated with l-dopa/entacapone, 22 untreated PD and 30 controls, and compared the flow-mediated dilation in these subjects. Results: The flow-mediated dilation was significantly lower in PD patients with l-dopa (6.0±1.8%) than in those with l-dopa/entacapone (7.2±1.1%, P=0.03), untreated PD patients (7.8±1.2%, P<0.05), and controls (8.5±2.9%, P<0.05). The homocysteine level was significantly higher in PD patients with l-dopa than in other groups. In a multivariate logistic regression model, the uppermost homocysteine quartile was an independent predictor of the lowest tertile of flow-mediated dilation (odds ratio, 6.33; 95% confidence interval, 1.61-26.65; P=0.012). Conclusions: Our findings indicate that endothelial dysfunction may be associated with chronic l-dopa treatment in patients with PD.

Original languageEnglish
Pages (from-to)1551-1555
Number of pages5
JournalMovement Disorders
Volume29
Issue number12
DOIs
Publication statusPublished - 2014 Jan 1

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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