Endothelial dysfunction in patients with exaggerated blood pressure response during treadmill test

Hyuk Jae Chang, Jaehoon Chung, So Yeon Choi, Myeong Ho Yoon, Gyo Seung Hwang, Joon Han Shin, Seung Jea Tahk, Byung Il William Choi

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Abstract

Background: The diagnostic and prognostic importance of exaggerated blood pressure response to exercise is controversial. Endothelial dysfunction has been demonstrated in patients with atherosclerosis and risk factors for coronary artery disease, but there is a paucity of information on patients with exercise-induced hypertension. Hypothesis: We designed the study to evaluate endothelial function in patients with exaggerated blood pressure response during exercise. Methods: Exercise-induced hypertension was defined as systolic blood pressure ≥210 mmHg in men and ≥190 mmHg in women during the treadmill test. Using a high-resolution ultrasound technique, endothelial function of the brachial artery in patients with exercise-induced hypertension (n = 25) and control subjects (n = 25) was investigated. Results: Endothelium-dependent vasodilation was impaired in patients with exercise-induced hypertension compared with controls (7.77 ± 5.14 vs. 2.81 ± 2.29%, p < 0.05). On univariate analysis, the extent of vasodilation correlated negatively with age (r = -0.43, p < 0.05) and A systolic blood pressure (r = -0.39, p < 0.05). Even after adjustment for factors known to affect endothelial function, endothelium-dependent vasodilation was decreased in patients with exercise-induced hypertension (β = 5.375, p = 0.02). Conclusion: Patients with exercise-induced hypertension have impaired endothelium-dependent vasodilation. This study also supports the concept that endothelial dysfunction may play an important role in exercise-induced hypertension.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalClinical Cardiology
Volume27
Issue number7
DOIs
Publication statusPublished - 2004 Jul

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Chang, H. J., Chung, J., Choi, S. Y., Yoon, M. H., Hwang, G. S., Shin, J. H., Tahk, S. J., & Choi, B. I. W. (2004). Endothelial dysfunction in patients with exaggerated blood pressure response during treadmill test. Clinical Cardiology, 27(7), 421-425. https://doi.org/10.1002/clc.4960270713