Endothelial progenitor cell homing: Prominent role of the IGF2-IGF2R-PLC 22 axis

Yong Sun Maeng, Hyun Jung Choi, Ja Young Kwon, Yong Won Park, Kyu Sil Choi, Jeong Ki Min, Yun Hee Kim, Pann Ghill Suh, Kyung Sun Kang, Moo Ho Won, Young Myeong Kim, Young Guen Kwon

Research output: Contribution to journalArticlepeer-review

116 Citations (Scopus)

Abstract

Homing of endothelial progenitor cells (EPCs) to the neovascular zone is now considered to be an essential step in the formation of vascular networks during embryonic development and also for neovascularization in postnatal life. We report here the prominent role of the insulinlike growth factor 2 (IGF2)/IGF2 receptor (IGF2R) system in promoting EPC homing. With high-level expression of IGF2R in EPCs, IGF2-induced hypoxic conditions stimulated multiple steps of EPC homing in vitro and promoted both EPC recruitment and incorporation into the neovascular area, resulting in enhanced angiogenesis in vivo. Remarkably, all IGF2 actions were exerted predominantly through IGF2R-linked G(i) protein signaling and required intracellular Ca2 + mobilization induced by the β 2 isoform of phospholipase C. Together, these findings indicate that locally generated IGF2 at either ischemic or tumor sites may contribute to postnatal vasculogenesis by augmenting the recruitment of EPCs. The utilization of the IGF2/IGF2R system may therefore be useful for the development of novel means to treat angiogenesisdependent diseases.

Original languageEnglish
Pages (from-to)233-243
Number of pages11
JournalBlood
Volume113
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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