Endovascular therapy combined with immunosuppressive treatment for pseudoaneurysms in patients with behçet's disease

Bon Kwon Koo, Won Heum Shim, Young sup Yoon, Byoung Kwon Lee, Donghoon Choi, Yangsoo Jang, Do Yun Lee, Byung chul Chang

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Abstract

Purpose: To evaluate the feasibility, efficacy, and outcome of endovascular therapy combined with immunosuppression for the treatment of arterial pseudoaneurysms due to Behçet's disease. Methods: Eleven pseudoaneurysms (3 in the abdominal aorta, 3 in the subclavian artery, and individual lesions in the brachiocephalic artery, renal artery, common iliac artery, common carotid artery, and the descending thoracic aorta) in 9 patients with Behçet's disease were treated with 10 stent-grafts and 1 self-expanding stent. All patients with elevated erythrocyte sedimentation rate (ESR) were treated with immunosuppressive agents (azathioprine, prednisolone) before and after the procedure. Results: Endovascular treatment was successful in all cases, without major adverse events. The ESR was reduced from 42.7±18.0 mm/h initially to 18.6±12.6 mm/h after immunosuppressive therapy prior to endovascular repair. During follow-up (mean 24.1±14.0 months, range 6-43), 8 of 11 lesions showed complete resolution. One stent-graft to treat a postsurgical recurrent carotid artery pseudoaneurysm was occluded, and an abdominal aortic pseudoaneurysm recurred; both patients stopped their medications. ESR during follow-up was 7.9±4.5 mm/h. Conclusions: Endovascular treatment for pseudoaneurysms due to Behçet's disease is feasible and effective when disease activity is strictly controlled with immunosuppressive therapy.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalJournal of Endovascular Therapy
Volume10
Issue number1
DOIs
Publication statusPublished - 2003 Feb 1

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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