Engineered magnetic hybrid nanoparticles with enhanced relaxivity for tumor imaging

Santosh Aryal, Jaehong Key, Cinzia Stigliano, Jeyarama S. Ananta, Meng Zhong, Paolo Decuzzi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Clinically used contrast agents for magnetic resonance imaging (MRI) suffer by the lack of specificity; short circulation time; and insufficient relaxivity. Here, a one-step combinatorial approach is described for the synthesis of magnetic lipid-polymer (hybrid) nanoparticles (MHNPs) encapsulating 5nm ultra-small super-paramagnetic iron oxide particles (USPIOs) and decorated with Gd3+ ions. The MHNPs comprise a hydrophobic poly(lactic acid-co-glycolic acid) (PLGA) core, containing up to ~5% USPIOs (w/w), stabilized by lipid and polyethylene glycol (PEG). Gd3+ ions are directly chelated to the external lipid monolayer. Three different nanoparticle configurations are presented including Gd3+ chelates only (Gd-MHNPs); USPIOs only (Fe-MHNPs); and the combination thereof (MHNPs). All three MHNPs exhibit a hydrodynamic diameter of about 150nm. The Gd-MHNPs present a longitudinal relaxivity (r1=12.95±0.53 (mms)-1) about four times larger than conventional Gd-based contrast agents (r1=3.4 (mms)-1); MHNPs have a transversal relaxivity of r2=164.07±7.0 (mms)-1, which is three to four times larger than most conventional systems (r2~50 (mms)-1). In melanoma bearing mice, elemental analysis for Gd shows about 3% of the injected MHNPs accumulating in the tumor and 2% still circulating in the blood, at 24h post-injection. In a clinical 3T MRI scanner, MHNPs provide significant contrast confirming the observed tumor deposition. This approach can also accommodate the co-loading of hydrophobic therapeutic compounds in the MHNP core, paving the way for theranostic systems.

Original languageEnglish
Pages (from-to)7725-7732
Number of pages8
JournalBiomaterials
Volume34
Issue number31
DOIs
Publication statusPublished - 2013 Oct 1

Fingerprint

Iron oxides
Nanoparticles
Lipids
Tumors
glycolic acid
Magnetic resonance
Imaging techniques
Contrast Media
Bearings (structural)
Magnetic Resonance Imaging
Ions
Neoplasms
Hydrodynamics
Lactic acid
Polyethylene glycols
Monolayers
Melanoma
Polymers
Blood
Injections

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Aryal, Santosh ; Key, Jaehong ; Stigliano, Cinzia ; Ananta, Jeyarama S. ; Zhong, Meng ; Decuzzi, Paolo. / Engineered magnetic hybrid nanoparticles with enhanced relaxivity for tumor imaging. In: Biomaterials. 2013 ; Vol. 34, No. 31. pp. 7725-7732.
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Aryal, S, Key, J, Stigliano, C, Ananta, JS, Zhong, M & Decuzzi, P 2013, 'Engineered magnetic hybrid nanoparticles with enhanced relaxivity for tumor imaging', Biomaterials, vol. 34, no. 31, pp. 7725-7732. https://doi.org/10.1016/j.biomaterials.2013.07.003

Engineered magnetic hybrid nanoparticles with enhanced relaxivity for tumor imaging. / Aryal, Santosh; Key, Jaehong; Stigliano, Cinzia; Ananta, Jeyarama S.; Zhong, Meng; Decuzzi, Paolo.

In: Biomaterials, Vol. 34, No. 31, 01.10.2013, p. 7725-7732.

Research output: Contribution to journalArticle

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