Engineering biomaterial systems to enhance viral vector gene delivery

Jae-Hyung Jang, David V. Schaffer, Lonnie D. Shea

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

Integrating viral gene delivery with engineered biomaterials is a promising strategy to overcome a number of challenges associated with virus-mediated gene delivery, including inefficient delivery to specific cell types, limited tropism, spread of vectors to distant sites, and immune responses. Viral vectors can be combined with biomaterials either through encapsulation within the material or immobilization onto a material surface. Subsequent biomaterial-based delivery can increase the vector's residence time within the target site, thereby potentially providing localized delivery, enhancing transduction, and extending the duration of gene expression. Alternatively, physical or chemical modification of viral vectors with biomaterials can be employed to modulate the tropism of viruses or reduce inflammatory and immune responses, both of which may benefit transduction. This review describes strategies to promote viral gene delivery technologies using biomaterials, potentially providing opportunities for numerous applications of gene therapy to inherited or acquired disorders, infectious disease, and regenerative medicine.

Original languageEnglish
Pages (from-to)1407-1415
Number of pages9
JournalMolecular Therapy
Volume19
Issue number8
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Viral Genes
Biocompatible Materials
Tropism
Infectious Disease Medicine
Satellite Viruses
Regenerative Medicine
Immobilization
Genetic Therapy
Viruses
Technology
Gene Expression
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

Cite this

Jang, Jae-Hyung ; Schaffer, David V. ; Shea, Lonnie D. / Engineering biomaterial systems to enhance viral vector gene delivery. In: Molecular Therapy. 2011 ; Vol. 19, No. 8. pp. 1407-1415.
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Engineering biomaterial systems to enhance viral vector gene delivery. / Jang, Jae-Hyung; Schaffer, David V.; Shea, Lonnie D.

In: Molecular Therapy, Vol. 19, No. 8, 01.01.2011, p. 1407-1415.

Research output: Contribution to journalReview article

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