Engineering discoidal polymeric nanoconstructs with enhanced magneto-optical properties for tumor imaging

Jaehong Key, Santosh Aryal, Francesco Gentile, Jeyarama S. Ananta, Meng Zhong, Melissa D. Landis, Paolo Decuzzi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The invivo performance of nanoparticles is affected by their size, shape and surface properties. Fabrication methods based on emulsification and nano-precipitation cannot control these features precisely and independently over multiple scales. Herein, discoidal polymeric nanoconstructs (DPNs) with a diameter of 1000nm and a height of 500nm are demonstrated via a modified hydrogel-template strategy. The DPNs are obtained by mixing in one synthesis step the constituent polymers - poly(lactic acid-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) dimethacrylate - and the payload with magneto-optical properties - 5nm ultra-small super-paramagnetic iron oxide nanoparticles (SPIOs) and Rhodamine B dye (RhB). The DPN geometrical features are characterized by multiple microscopy techniques. The release of the Rhodamine B dye is pH dependent and increases under acidic conditions by the enhanced hydrolysis of the polymeric matrix. Each DPN is loaded with ~100fg of iron and can be efficiently dragged by static and external magnetic fields. Moreover, the USPIO confinement within the DPN porous structure is responsible for a significant enhancement in MRI relaxivity (r2~500 (mMs)-1), up to ~5 times larger than commercially available systems. These nanoconstructs suggest a general strategy to engineer theranostic systems for anti-angiogenic treatment and vascular imaging.

Original languageEnglish
Pages (from-to)5402-5410
Number of pages9
JournalBiomaterials
Volume34
Issue number21
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

rhodamine B
glycolic acid
Nanoparticles
Tumors
Coloring Agents
Dyes
Optical properties
Imaging techniques
Plasma confinement
Emulsification
Surface Properties
Hydrogel
Magnetic Fields
Lactic acid
Iron oxides
Hydrogels
Magnetic resonance imaging
Polyethylene glycols
Surface properties
Blood Vessels

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Key, Jaehong ; Aryal, Santosh ; Gentile, Francesco ; Ananta, Jeyarama S. ; Zhong, Meng ; Landis, Melissa D. ; Decuzzi, Paolo. / Engineering discoidal polymeric nanoconstructs with enhanced magneto-optical properties for tumor imaging. In: Biomaterials. 2013 ; Vol. 34, No. 21. pp. 5402-5410.
@article{72c5ab7e70ae44cbb0d0f37f192e7735,
title = "Engineering discoidal polymeric nanoconstructs with enhanced magneto-optical properties for tumor imaging",
abstract = "The invivo performance of nanoparticles is affected by their size, shape and surface properties. Fabrication methods based on emulsification and nano-precipitation cannot control these features precisely and independently over multiple scales. Herein, discoidal polymeric nanoconstructs (DPNs) with a diameter of 1000nm and a height of 500nm are demonstrated via a modified hydrogel-template strategy. The DPNs are obtained by mixing in one synthesis step the constituent polymers - poly(lactic acid-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) dimethacrylate - and the payload with magneto-optical properties - 5nm ultra-small super-paramagnetic iron oxide nanoparticles (SPIOs) and Rhodamine B dye (RhB). The DPN geometrical features are characterized by multiple microscopy techniques. The release of the Rhodamine B dye is pH dependent and increases under acidic conditions by the enhanced hydrolysis of the polymeric matrix. Each DPN is loaded with ~100fg of iron and can be efficiently dragged by static and external magnetic fields. Moreover, the USPIO confinement within the DPN porous structure is responsible for a significant enhancement in MRI relaxivity (r2~500 (mMs)-1), up to ~5 times larger than commercially available systems. These nanoconstructs suggest a general strategy to engineer theranostic systems for anti-angiogenic treatment and vascular imaging.",
author = "Jaehong Key and Santosh Aryal and Francesco Gentile and Ananta, {Jeyarama S.} and Meng Zhong and Landis, {Melissa D.} and Paolo Decuzzi",
year = "2013",
month = "7",
day = "1",
doi = "10.1016/j.biomaterials.2013.03.078",
language = "English",
volume = "34",
pages = "5402--5410",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier BV",
number = "21",

}

Engineering discoidal polymeric nanoconstructs with enhanced magneto-optical properties for tumor imaging. / Key, Jaehong; Aryal, Santosh; Gentile, Francesco; Ananta, Jeyarama S.; Zhong, Meng; Landis, Melissa D.; Decuzzi, Paolo.

In: Biomaterials, Vol. 34, No. 21, 01.07.2013, p. 5402-5410.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Engineering discoidal polymeric nanoconstructs with enhanced magneto-optical properties for tumor imaging

AU - Key, Jaehong

AU - Aryal, Santosh

AU - Gentile, Francesco

AU - Ananta, Jeyarama S.

AU - Zhong, Meng

AU - Landis, Melissa D.

AU - Decuzzi, Paolo

PY - 2013/7/1

Y1 - 2013/7/1

N2 - The invivo performance of nanoparticles is affected by their size, shape and surface properties. Fabrication methods based on emulsification and nano-precipitation cannot control these features precisely and independently over multiple scales. Herein, discoidal polymeric nanoconstructs (DPNs) with a diameter of 1000nm and a height of 500nm are demonstrated via a modified hydrogel-template strategy. The DPNs are obtained by mixing in one synthesis step the constituent polymers - poly(lactic acid-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) dimethacrylate - and the payload with magneto-optical properties - 5nm ultra-small super-paramagnetic iron oxide nanoparticles (SPIOs) and Rhodamine B dye (RhB). The DPN geometrical features are characterized by multiple microscopy techniques. The release of the Rhodamine B dye is pH dependent and increases under acidic conditions by the enhanced hydrolysis of the polymeric matrix. Each DPN is loaded with ~100fg of iron and can be efficiently dragged by static and external magnetic fields. Moreover, the USPIO confinement within the DPN porous structure is responsible for a significant enhancement in MRI relaxivity (r2~500 (mMs)-1), up to ~5 times larger than commercially available systems. These nanoconstructs suggest a general strategy to engineer theranostic systems for anti-angiogenic treatment and vascular imaging.

AB - The invivo performance of nanoparticles is affected by their size, shape and surface properties. Fabrication methods based on emulsification and nano-precipitation cannot control these features precisely and independently over multiple scales. Herein, discoidal polymeric nanoconstructs (DPNs) with a diameter of 1000nm and a height of 500nm are demonstrated via a modified hydrogel-template strategy. The DPNs are obtained by mixing in one synthesis step the constituent polymers - poly(lactic acid-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) dimethacrylate - and the payload with magneto-optical properties - 5nm ultra-small super-paramagnetic iron oxide nanoparticles (SPIOs) and Rhodamine B dye (RhB). The DPN geometrical features are characterized by multiple microscopy techniques. The release of the Rhodamine B dye is pH dependent and increases under acidic conditions by the enhanced hydrolysis of the polymeric matrix. Each DPN is loaded with ~100fg of iron and can be efficiently dragged by static and external magnetic fields. Moreover, the USPIO confinement within the DPN porous structure is responsible for a significant enhancement in MRI relaxivity (r2~500 (mMs)-1), up to ~5 times larger than commercially available systems. These nanoconstructs suggest a general strategy to engineer theranostic systems for anti-angiogenic treatment and vascular imaging.

UR - http://www.scopus.com/inward/record.url?scp=84877015120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877015120&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2013.03.078

DO - 10.1016/j.biomaterials.2013.03.078

M3 - Article

C2 - 23611451

AN - SCOPUS:84877015120

VL - 34

SP - 5402

EP - 5410

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

IS - 21

ER -