Engineering nanocarriers for siRNA delivery

Shawn J. Tan, Pichamon Kiatwuthinon, Young Hoon Roh, Jason S. Kahn, Dan Luo

Research output: Contribution to journalReview article

85 Citations (Scopus)

Abstract

The discovery of RNA interference has revitalized the long ongoing pursuit of gene therapy for the treatment of diseases. Nevertheless, despite promising results from experimental studies, there remains a pressing need for the development of nanocarriers that are clinically-relevant, biocompatible, efficient, and that can be tailored to specific disease targets. This review surveys the broad spectrum of nanomaterials and their functional add-ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery. Nanomaterials for drug delivery: There is a pressing need for the development of nanocarriers that are clinically-relevant, biocompatible, efficient, and that can be tailored to specific disease targets. This review surveys the broad spectrum of nanomaterials and their functional add-ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery.

Original languageEnglish
Pages (from-to)841-856
Number of pages16
JournalSmall
Volume7
Issue number7
DOIs
Publication statusPublished - 2011 Apr 4

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Nanostructures
Nanostructured materials
Small Interfering RNA
Gene therapy
RNA Interference
RNA
Drug delivery
Genetic Therapy
Pharmaceutical Preparations
Surveys and Questionnaires
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

Tan, S. J., Kiatwuthinon, P., Roh, Y. H., Kahn, J. S., & Luo, D. (2011). Engineering nanocarriers for siRNA delivery. Small, 7(7), 841-856. https://doi.org/10.1002/smll.201001389
Tan, Shawn J. ; Kiatwuthinon, Pichamon ; Roh, Young Hoon ; Kahn, Jason S. ; Luo, Dan. / Engineering nanocarriers for siRNA delivery. In: Small. 2011 ; Vol. 7, No. 7. pp. 841-856.
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Tan, SJ, Kiatwuthinon, P, Roh, YH, Kahn, JS & Luo, D 2011, 'Engineering nanocarriers for siRNA delivery', Small, vol. 7, no. 7, pp. 841-856. https://doi.org/10.1002/smll.201001389

Engineering nanocarriers for siRNA delivery. / Tan, Shawn J.; Kiatwuthinon, Pichamon; Roh, Young Hoon; Kahn, Jason S.; Luo, Dan.

In: Small, Vol. 7, No. 7, 04.04.2011, p. 841-856.

Research output: Contribution to journalReview article

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Tan SJ, Kiatwuthinon P, Roh YH, Kahn JS, Luo D. Engineering nanocarriers for siRNA delivery. Small. 2011 Apr 4;7(7):841-856. https://doi.org/10.1002/smll.201001389