Engineering nanocarriers for siRNA delivery

Shawn J. Tan, Pichamon Kiatwuthinon, Young Hoon Roh, Jason S. Kahn, Dan Luo

Research output: Contribution to journalReview article

88 Citations (Scopus)

Abstract

The discovery of RNA interference has revitalized the long ongoing pursuit of gene therapy for the treatment of diseases. Nevertheless, despite promising results from experimental studies, there remains a pressing need for the development of nanocarriers that are clinically-relevant, biocompatible, efficient, and that can be tailored to specific disease targets. This review surveys the broad spectrum of nanomaterials and their functional add-ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery. Nanomaterials for drug delivery: There is a pressing need for the development of nanocarriers that are clinically-relevant, biocompatible, efficient, and that can be tailored to specific disease targets. This review surveys the broad spectrum of nanomaterials and their functional add-ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery.

Original languageEnglish
Pages (from-to)841-856
Number of pages16
JournalSmall
Volume7
Issue number7
DOIs
Publication statusPublished - 2011 Apr 4

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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    Tan, S. J., Kiatwuthinon, P., Roh, Y. H., Kahn, J. S., & Luo, D. (2011). Engineering nanocarriers for siRNA delivery. Small, 7(7), 841-856. https://doi.org/10.1002/smll.201001389