Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin

Soomin Kim, Ji Eun Jang, Jihee Kim, Young In Lee, Dong Won Lee, Seung Yong Song, Ju Hee Lee

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Natural plant oils have been used as a translational alternative to modern medicine. Particularly, virgin coconut oil (VCO) has gained popularity because of its potential benefits in pharmaceutical, nutritional, and cosmetic applications. Cultured coconut extract (CCE) is an alternative end product of VCO, which undergoes a further bacterial fermentation process. This study aimed to investigate the effects of CCE on human skin. We analyzed the expression of skin barrier molecules and collagens after applying CCE on human explanted skin. To evaluate the anti-inflammatory properties of CCE, the expression of inflammatory markers was analyzed after ultraviolet B (UVB) irradiation. The CCE-treated group showed increased expression of cornified cell envelope components, which contribute to protective barrier functions of the stratum corneum. Further, the expression of inflammatory markers was lower in the CCE-treated group after exposure to UVB radiation. These results suggest an anti-inflammatory effect of CCE against UVB irradiation-induced inflammation. Additionally, the CCE-treated group showed increased collagen and hyaluronan synthase-3 expression. In our study, CCE showed a barrier-enhancing effect and anti-inflammatory properties against ex vivo UVB irradiation-induced inflammation. The promising effect of CCE may be attributed to its high levels of polyphenols and fatty acid components.

Original languageEnglish
Pages (from-to)367-375
Number of pages9
JournalFood and Chemical Toxicology
Volume106
DOIs
Publication statusPublished - 2017 Aug

Bibliographical note

Funding Information:
This research was supported by National Research Foundation of Korea (grant number: NRF-2014M3A7B4051596) and faculty research grant of Yonsei University College of Medicine (6-2010-0057). This study was also partially supported by Naerok Resource.

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Fingerprint Dive into the research topics of 'Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin'. Together they form a unique fingerprint.

Cite this