Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin

Soomin Kim, Ji Eun Jang, Jihee Kim, Young In Lee, Dong Won Lee, Seung Yong Song, JuHee Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Natural plant oils have been used as a translational alternative to modern medicine. Particularly, virgin coconut oil (VCO) has gained popularity because of its potential benefits in pharmaceutical, nutritional, and cosmetic applications. Cultured coconut extract (CCE) is an alternative end product of VCO, which undergoes a further bacterial fermentation process. This study aimed to investigate the effects of CCE on human skin. We analyzed the expression of skin barrier molecules and collagens after applying CCE on human explanted skin. To evaluate the anti-inflammatory properties of CCE, the expression of inflammatory markers was analyzed after ultraviolet B (UVB) irradiation. The CCE-treated group showed increased expression of cornified cell envelope components, which contribute to protective barrier functions of the stratum corneum. Further, the expression of inflammatory markers was lower in the CCE-treated group after exposure to UVB radiation. These results suggest an anti-inflammatory effect of CCE against UVB irradiation-induced inflammation. Additionally, the CCE-treated group showed increased collagen and hyaluronan synthase-3 expression. In our study, CCE showed a barrier-enhancing effect and anti-inflammatory properties against ex vivo UVB irradiation-induced inflammation. The promising effect of CCE may be attributed to its high levels of polyphenols and fatty acid components.

Original languageEnglish
Pages (from-to)367-375
Number of pages9
JournalFood and Chemical Toxicology
Volume106
DOIs
Publication statusPublished - 2017 Aug 1

Fingerprint

Cocos
coconuts
anti-inflammatory activity
skin (animal)
Skin
Anti-Inflammatory Agents
Irradiation
extracts
Collagen
Plant Oils
Cosmetics
Polyphenols
ultraviolet radiation
Fermentation
Medicine
Fatty Acids
Cells
coconut oil
irradiation
Radiation

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

Kim, Soomin ; Jang, Ji Eun ; Kim, Jihee ; Lee, Young In ; Lee, Dong Won ; Song, Seung Yong ; Lee, JuHee. / Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin. In: Food and Chemical Toxicology. 2017 ; Vol. 106. pp. 367-375.
@article{75ce52c33ab44a759159f308bec9f88b,
title = "Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin",
abstract = "Natural plant oils have been used as a translational alternative to modern medicine. Particularly, virgin coconut oil (VCO) has gained popularity because of its potential benefits in pharmaceutical, nutritional, and cosmetic applications. Cultured coconut extract (CCE) is an alternative end product of VCO, which undergoes a further bacterial fermentation process. This study aimed to investigate the effects of CCE on human skin. We analyzed the expression of skin barrier molecules and collagens after applying CCE on human explanted skin. To evaluate the anti-inflammatory properties of CCE, the expression of inflammatory markers was analyzed after ultraviolet B (UVB) irradiation. The CCE-treated group showed increased expression of cornified cell envelope components, which contribute to protective barrier functions of the stratum corneum. Further, the expression of inflammatory markers was lower in the CCE-treated group after exposure to UVB radiation. These results suggest an anti-inflammatory effect of CCE against UVB irradiation-induced inflammation. Additionally, the CCE-treated group showed increased collagen and hyaluronan synthase-3 expression. In our study, CCE showed a barrier-enhancing effect and anti-inflammatory properties against ex vivo UVB irradiation-induced inflammation. The promising effect of CCE may be attributed to its high levels of polyphenols and fatty acid components.",
author = "Soomin Kim and Jang, {Ji Eun} and Jihee Kim and Lee, {Young In} and Lee, {Dong Won} and Song, {Seung Yong} and JuHee Lee",
year = "2017",
month = "8",
day = "1",
doi = "10.1016/j.fct.2017.05.060",
language = "English",
volume = "106",
pages = "367--375",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",

}

Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin. / Kim, Soomin; Jang, Ji Eun; Kim, Jihee; Lee, Young In; Lee, Dong Won; Song, Seung Yong; Lee, JuHee.

In: Food and Chemical Toxicology, Vol. 106, 01.08.2017, p. 367-375.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin

AU - Kim, Soomin

AU - Jang, Ji Eun

AU - Kim, Jihee

AU - Lee, Young In

AU - Lee, Dong Won

AU - Song, Seung Yong

AU - Lee, JuHee

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Natural plant oils have been used as a translational alternative to modern medicine. Particularly, virgin coconut oil (VCO) has gained popularity because of its potential benefits in pharmaceutical, nutritional, and cosmetic applications. Cultured coconut extract (CCE) is an alternative end product of VCO, which undergoes a further bacterial fermentation process. This study aimed to investigate the effects of CCE on human skin. We analyzed the expression of skin barrier molecules and collagens after applying CCE on human explanted skin. To evaluate the anti-inflammatory properties of CCE, the expression of inflammatory markers was analyzed after ultraviolet B (UVB) irradiation. The CCE-treated group showed increased expression of cornified cell envelope components, which contribute to protective barrier functions of the stratum corneum. Further, the expression of inflammatory markers was lower in the CCE-treated group after exposure to UVB radiation. These results suggest an anti-inflammatory effect of CCE against UVB irradiation-induced inflammation. Additionally, the CCE-treated group showed increased collagen and hyaluronan synthase-3 expression. In our study, CCE showed a barrier-enhancing effect and anti-inflammatory properties against ex vivo UVB irradiation-induced inflammation. The promising effect of CCE may be attributed to its high levels of polyphenols and fatty acid components.

AB - Natural plant oils have been used as a translational alternative to modern medicine. Particularly, virgin coconut oil (VCO) has gained popularity because of its potential benefits in pharmaceutical, nutritional, and cosmetic applications. Cultured coconut extract (CCE) is an alternative end product of VCO, which undergoes a further bacterial fermentation process. This study aimed to investigate the effects of CCE on human skin. We analyzed the expression of skin barrier molecules and collagens after applying CCE on human explanted skin. To evaluate the anti-inflammatory properties of CCE, the expression of inflammatory markers was analyzed after ultraviolet B (UVB) irradiation. The CCE-treated group showed increased expression of cornified cell envelope components, which contribute to protective barrier functions of the stratum corneum. Further, the expression of inflammatory markers was lower in the CCE-treated group after exposure to UVB radiation. These results suggest an anti-inflammatory effect of CCE against UVB irradiation-induced inflammation. Additionally, the CCE-treated group showed increased collagen and hyaluronan synthase-3 expression. In our study, CCE showed a barrier-enhancing effect and anti-inflammatory properties against ex vivo UVB irradiation-induced inflammation. The promising effect of CCE may be attributed to its high levels of polyphenols and fatty acid components.

UR - http://www.scopus.com/inward/record.url?scp=85020312266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020312266&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2017.05.060

DO - 10.1016/j.fct.2017.05.060

M3 - Article

VL - 106

SP - 367

EP - 375

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -