Abstract
Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.
Original language | English |
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Pages (from-to) | 514-518 |
Number of pages | 5 |
Journal | Journal of Biophotonics |
Volume | 4 |
Issue number | 7-8 |
DOIs | |
Publication status | Published - 2011 Aug |
All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Materials Science(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Engineering(all)
- Physics and Astronomy(all)