Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation

Praveen C. Ashok; Anna Chiara De Luca; Michael Mazilu; Kishan Dholakia

doi:10.1002/jbio.201000107

Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation

Praveen C. Ashok, Anna Chiara De Luca, Michael Mazilu, Kishan Dholakia

Department of Physics

Research output: Contribution to journal › Letter › peer-review

29 Citations (Scopus)

Abstract

Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.

Original language	English
Pages (from-to)	514-518
Number of pages	5
Journal	Journal of Biophotonics
Volume	4
Issue number	7-8
DOIs	https://doi.org/10.1002/jbio.201000107
Publication status	Published - 2011 Aug

All Science Journal Classification (ASJC) codes

Chemistry(all)
Materials Science(all)
Biochemistry, Genetics and Molecular Biology(all)
Engineering(all)
Physics and Astronomy(all)

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10.1002/jbio.201000107

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title = "Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation",

abstract = "Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.",

author = "Ashok, {Praveen C.} and {De Luca}, {Anna Chiara} and Michael Mazilu and Kishan Dholakia",

year = "2011",

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language = "English",

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pages = "514--518",

journal = "Journal of Biophotonics",

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T1 - Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation

AU - Ashok, Praveen C.

AU - De Luca, Anna Chiara

AU - Mazilu, Michael

AU - Dholakia, Kishan

PY - 2011/8

Y1 - 2011/8

N2 - Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.

AB - Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.

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JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 7-8

ER -

Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation

Abstract

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