Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation

Praveen C. Ashok, Anna Chiara De Luca, Michael Mazilu, Kishan Dholakia

Research output: Contribution to journalLetter

28 Citations (Scopus)

Abstract

Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.

Original languageEnglish
Pages (from-to)514-518
Number of pages5
JournalJournal of Biophotonics
Volume4
Issue number7-8
DOIs
Publication statusPublished - 2011 Aug

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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