Enhanced biolubrication on biomedical devices using hyaluronic acid-silica nanohybrid hydrogels

Changha Hwang; You Jin Min; Yun Jeong Seong; Dae Eun Kim; Hyoun Ee Kim; Seol Ha Jeong

doi:10.1016/j.colsurfb.2019.110503

Enhanced biolubrication on biomedical devices using hyaluronic acid-silica nanohybrid hydrogels

Changha Hwang, You Jin Min, Yun Jeong Seong, Dae Eun Kim, Hyoun Ee Kim, Seol Ha Jeong

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In this work, highly lubricous hyaluronic acid-silica (HA-SiO₂) nanohybrid coatings were fabricated through a sequential process consisting of a sol-gel followed by electrophoretic deposition (EPD). SiO₂ nanoparticles were uniformly distributed in the coating layers, and the coating thickness was identified as approximately 1–2 μm regardless of the amount of SiO_2. Incorporation of SiO₂ into the HA polymer matrix enhanced the mechanical stability of the nanohybrid coatings, indicating greater interfacial bonding strength compared to HA coating layers alone. In addition, due to improved stability, the nanohybrid coatings showed excellent biolubrication properties, which were evaluated with a tribological experiment. These results indicate that the nanohybrid coatings have great potential to be used in biomedical applications that require superior biolubrication properties.

Original language	English
Article number	110503
Journal	Colloids and Surfaces B: Biointerfaces
Volume	184
DOIs	https://doi.org/10.1016/j.colsurfb.2019.110503
Publication status	Published - 2019 Dec 1

Bibliographical note

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) , funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C0493 ) Appendix A

Publisher Copyright:
© 2019

All Science Journal Classification (ASJC) codes

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

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title = "Enhanced biolubrication on biomedical devices using hyaluronic acid-silica nanohybrid hydrogels",

abstract = "In this work, highly lubricous hyaluronic acid-silica (HA-SiO2) nanohybrid coatings were fabricated through a sequential process consisting of a sol-gel followed by electrophoretic deposition (EPD). SiO2 nanoparticles were uniformly distributed in the coating layers, and the coating thickness was identified as approximately 1–2 μm regardless of the amount of SiO2. Incorporation of SiO2 into the HA polymer matrix enhanced the mechanical stability of the nanohybrid coatings, indicating greater interfacial bonding strength compared to HA coating layers alone. In addition, due to improved stability, the nanohybrid coatings showed excellent biolubrication properties, which were evaluated with a tribological experiment. These results indicate that the nanohybrid coatings have great potential to be used in biomedical applications that require superior biolubrication properties.",

author = "Changha Hwang and Min, {You Jin} and Seong, {Yun Jeong} and Kim, {Dae Eun} and Kim, {Hyoun Ee} and Jeong, {Seol Ha}",

note = "Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) , funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C0493 ) Appendix A Publisher Copyright: {\textcopyright} 2019",

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AU - Hwang, Changha

AU - Min, You Jin

AU - Seong, Yun Jeong

AU - Kim, Dae Eun

AU - Kim, Hyoun Ee

AU - Jeong, Seol Ha

N1 - Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) , funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C0493 ) Appendix A Publisher Copyright: © 2019

PY - 2019/12/1

Y1 - 2019/12/1

N2 - In this work, highly lubricous hyaluronic acid-silica (HA-SiO2) nanohybrid coatings were fabricated through a sequential process consisting of a sol-gel followed by electrophoretic deposition (EPD). SiO2 nanoparticles were uniformly distributed in the coating layers, and the coating thickness was identified as approximately 1–2 μm regardless of the amount of SiO2. Incorporation of SiO2 into the HA polymer matrix enhanced the mechanical stability of the nanohybrid coatings, indicating greater interfacial bonding strength compared to HA coating layers alone. In addition, due to improved stability, the nanohybrid coatings showed excellent biolubrication properties, which were evaluated with a tribological experiment. These results indicate that the nanohybrid coatings have great potential to be used in biomedical applications that require superior biolubrication properties.

AB - In this work, highly lubricous hyaluronic acid-silica (HA-SiO2) nanohybrid coatings were fabricated through a sequential process consisting of a sol-gel followed by electrophoretic deposition (EPD). SiO2 nanoparticles were uniformly distributed in the coating layers, and the coating thickness was identified as approximately 1–2 μm regardless of the amount of SiO2. Incorporation of SiO2 into the HA polymer matrix enhanced the mechanical stability of the nanohybrid coatings, indicating greater interfacial bonding strength compared to HA coating layers alone. In addition, due to improved stability, the nanohybrid coatings showed excellent biolubrication properties, which were evaluated with a tribological experiment. These results indicate that the nanohybrid coatings have great potential to be used in biomedical applications that require superior biolubrication properties.

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Enhanced biolubrication on biomedical devices using hyaluronic acid-silica nanohybrid hydrogels

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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