Enhanced bone formation by marrow-derived endothelial and osteogenic cell transplantation

Sang Soo Kim, Min Sun Park, Seung-Woo Cho, Sun Woong Kang, Kang Min Ahn, Jong Ho Lee, Byung Soo Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Bone marrow-derived osteogenic cells can regenerate bone tissues in vivo. The aim of the present study is to determine whether the cotransplantation of bone marrowderived endothelial-like cells (BMECs) enhances bone regeneration by bone marrow-derived osteogenic cell (BMOC) transplantation in osseous defects. Canine bone marrow cells were differentiated separately into BMECs and BMOCs. Using apatite-coated poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds as cell delivery vehicles, BMOCs were transplanted with or without BMECs into critical-sized calvarial defects in immunodeficient mice. Histological analyses, microcomputed tomography, and soft X-ray were performed to assess mineralized bone formation at 8 weeks. Cotransplantation of BMECs and BMOCs resulted in greater bone formation than transplantation of BMOCs alone. There was a significant (p < 0.05) increase in bone formation area following cotransplantation (30.8% ± 2.5%), compared with transplantation of BMOCs alone (15.3% 6± 1.9%). These results demonstrate that the cotransplantation of BMECs enhances bone regeneration mediated by BMOC transplantation in osseous defects.

Original languageEnglish
Pages (from-to)246-253
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume92
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

Fingerprint

Bone
Defects
Polyglactin 910
Apatites
Apatite
Durapatite
Hydroxyapatite
Scaffolds
Tomography
Cells
Tissue
X rays

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Cite this

Kim, Sang Soo ; Park, Min Sun ; Cho, Seung-Woo ; Kang, Sun Woong ; Ahn, Kang Min ; Lee, Jong Ho ; Kim, Byung Soo. / Enhanced bone formation by marrow-derived endothelial and osteogenic cell transplantation. In: Journal of Biomedical Materials Research - Part A. 2010 ; Vol. 92, No. 1. pp. 246-253.
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Enhanced bone formation by marrow-derived endothelial and osteogenic cell transplantation. / Kim, Sang Soo; Park, Min Sun; Cho, Seung-Woo; Kang, Sun Woong; Ahn, Kang Min; Lee, Jong Ho; Kim, Byung Soo.

In: Journal of Biomedical Materials Research - Part A, Vol. 92, No. 1, 01.01.2010, p. 246-253.

Research output: Contribution to journalArticle

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