Enhanced cell differentiation when RB is hypophosphorylated and down-regulated by radicicol, a SRC-kinase inhibitor

Andrew Yen, Stephen Soong, Ho Jeong Kwon, Minoru Yoshida, Teruhiko Beppu, Susi Varvayanis

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Radicicol, an inhibitor of src or src-like kinases, causes hypophosphorylation and down-regulation of the RB retinoblastoma tumor suppressor protein in HL-60 human promyelocytic leukemia cells. Both of these changes in the RB protein typically are associated with myeloid or monocytic differentiation of these cells induced by retinoic acid or 1,25-dihydroxy vitamin D3. When added with either inducer, radicicol caused the typically induced myeloid or monocytic differentiation of these cells to be accelerated. By itself radicicol caused a transient inhibition of G1 to S transit, but did not cause phenotypic conversion. The down-regulation and dephosphorylation of RB by radicicol may thus facilitate cell differentiation.

Original languageEnglish
Pages (from-to)163-171
Number of pages9
JournalExperimental Cell Research
Volume214
Issue number1
DOIs
Publication statusPublished - 1994 Sep

All Science Journal Classification (ASJC) codes

  • Cell Biology

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