Enhanced cellular responses of vascular endothelial cells on poly-γ-glutamic acid/PU composite film treated with microwave-induced plasma at atmospheric pressure

Bong Joo Park, Byoung Ju Kwon, Jae Kyeong Kang, Mi Hee Lee, Inho Han, Jeong Koo Kim, Jong Chul Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Poly-γ-glutamic acid (γ-PGA), which is produced by microbial fermentation, is a biodegradable, hydrophilic and non-toxic biomaterial. γ-PGA has many carboxyl groups that makes it a polyanionic biopolymer with swelling ability, biocompatibility and anticoagulant activity. On the other hand, few studies have examined the effect of γ-PGA on the cellular activity of human umbilical vein endothelial cells (HUVECs). The present study evaluated the effects of γ-PGA and fabricated γ-PGA/PU composite films on the attachment and proliferation of HUVECs after treatment with microwave plasma at atmospheric pressure. The results confirmed that γ-PGA is capable of increasing the proliferation and differentiation of HUVECs to form capillary tubes with enhanced alignment and organization. Moreover, the microwave plasma modified γ-PGA/PU composite film was more hydrophilic and the surface roughness was enhanced. In addition, the attachment and proliferation of the HUVECs were increased by the plasma treatment. These results suggest that γ-PGA and surface modified γ-PGA/PU composite can be applied as bioactive and biocompatible materials in vascular tissue engineering but further testing of γ-PGA and γ-PGA/PU composite films will be needed to confirm the potential effects for use in vascular applications. [InlineMediaObject not available: see fulltext.]

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalMacromolecular Research
Volume19
Issue number6
DOIs
Publication statusPublished - 2011 Jun 1

Fingerprint

Prostaglandins A
Endothelial cells
Composite films
Atmospheric pressure
Glutamic Acid
Microwaves
Plasmas
Acids
Biomaterials
Capillary tubes
Biopolymers
Biocompatibility
Tissue engineering
Fermentation
Swelling
Biocompatible Materials
Surface roughness
Composite materials
Testing
Anticoagulants

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Park, Bong Joo ; Kwon, Byoung Ju ; Kang, Jae Kyeong ; Lee, Mi Hee ; Han, Inho ; Kim, Jeong Koo ; Park, Jong Chul. / Enhanced cellular responses of vascular endothelial cells on poly-γ-glutamic acid/PU composite film treated with microwave-induced plasma at atmospheric pressure. In: Macromolecular Research. 2011 ; Vol. 19, No. 6. pp. 537-541.
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abstract = "Poly-γ-glutamic acid (γ-PGA), which is produced by microbial fermentation, is a biodegradable, hydrophilic and non-toxic biomaterial. γ-PGA has many carboxyl groups that makes it a polyanionic biopolymer with swelling ability, biocompatibility and anticoagulant activity. On the other hand, few studies have examined the effect of γ-PGA on the cellular activity of human umbilical vein endothelial cells (HUVECs). The present study evaluated the effects of γ-PGA and fabricated γ-PGA/PU composite films on the attachment and proliferation of HUVECs after treatment with microwave plasma at atmospheric pressure. The results confirmed that γ-PGA is capable of increasing the proliferation and differentiation of HUVECs to form capillary tubes with enhanced alignment and organization. Moreover, the microwave plasma modified γ-PGA/PU composite film was more hydrophilic and the surface roughness was enhanced. In addition, the attachment and proliferation of the HUVECs were increased by the plasma treatment. These results suggest that γ-PGA and surface modified γ-PGA/PU composite can be applied as bioactive and biocompatible materials in vascular tissue engineering but further testing of γ-PGA and γ-PGA/PU composite films will be needed to confirm the potential effects for use in vascular applications. [InlineMediaObject not available: see fulltext.]",
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Enhanced cellular responses of vascular endothelial cells on poly-γ-glutamic acid/PU composite film treated with microwave-induced plasma at atmospheric pressure. / Park, Bong Joo; Kwon, Byoung Ju; Kang, Jae Kyeong; Lee, Mi Hee; Han, Inho; Kim, Jeong Koo; Park, Jong Chul.

In: Macromolecular Research, Vol. 19, No. 6, 01.06.2011, p. 537-541.

Research output: Contribution to journalArticle

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