Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination

Sang Jun Ha, Su Hyung Park, Hye Ju Kim, Seung Chul Kim, Hyang Ju Kang, Eun Gae Lee, Soon Geon Kwon, Byong Moon Kim, Sung Hee Lee, Won Bae Kim, Young Chul Sung, Sang Nae Cho

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.

Original languageEnglish
Pages (from-to)4954-4959
Number of pages6
JournalInfection and Immunity
Volume74
Issue number8
DOIs
Publication statusPublished - 2006 Aug

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination'. Together they form a unique fingerprint.

  • Cite this

    Ha, S. J., Park, S. H., Kim, H. J., Kim, S. C., Kang, H. J., Lee, E. G., Kwon, S. G., Kim, B. M., Lee, S. H., Kim, W. B., Sung, Y. C., & Cho, S. N. (2006). Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination. Infection and Immunity, 74(8), 4954-4959. https://doi.org/10.1128/IAI.01781-05