Enhanced Micro-Channeling System via Dissolving Microneedle to Improve Transdermal Serum Delivery for Various Clinical Skincare Treatments

Jeeho Sim, Seong Dae Gong, Geonwoo Kang, Mingyu Jang, Huisuk Yang, Jaesung Park, Youngchan Kim, Hyunkyu Lee, Hyunji Jung, Youseong Kim, Chansol Jeon, Hyeri Ahn, Minkyung Kim, Jaibyung Choi, Ho Lee, Hyungil Jung

Research output: Contribution to journalArticlepeer-review


Topical liquid formulations, dissolving microneedles (DMNs), and microscale needles composed of biodegradable materials have been widely used for the transdermal delivery of active compounds for skincare. However, transdermal active compound delivery by topical liquid formulation application is inhibited by skin barriers, and the skincare efficacy of DMNs is restricted by the low encapsulation capacity and incomplete insertion. In this study, topical serum application via a dissolvable micro-channeling system (DMCS) was used to enhance serum delivery through micro-channels embedded with DMNs. Transdermal serum delivery was evaluated after the topical-serum-only application and combinatorial serum application by assessing the intensity of allophycocyanin (APC) loaded with the serum in the porcine skin. APC intensity was significantly higher in the skin layer at a depth of 120–270 μm upon combinatorial serum application as compared to topical-serum-only application. In addition, the combinatorial serum application showed significantly improved efficacy in the clinical assessment of skin hydration, depigmentation, improvement of wrinkles, elasticity, dermal density, skin pores, and skin soothing without any safety issues compared to the serum-only application. The results indicate that combinatorial serum application with DMCS is a promising candidate for improving skincare treatments with optimal transdermal delivery of active compounds.

Original languageEnglish
Article number2804
Issue number12
Publication statusPublished - 2022 Dec

Bibliographical note

Funding Information:
This work was supported by the Industrial Core Technology Development Program (20000462, Development of anti-aging beauty care system using multi-active and controlled releasing transdermal delivery for skin-layer-specific effects) funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea), and Brain Korea 21 (BK21) program. Article processing charges were funded by the MDPI, and Jeeho Sim is grateful for financial support from Hyundai Motor Chung Mong-Koo Foundation.

Publisher Copyright:
© 2022 by the authors.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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