Enhanced neurite outgrowth of rat neural cortical cells on surface-modified films of poly(lactic-co-glycolic acid)

Dong Wook Han, Sub Lee Min, Joo Park Bong, Koo Kim Jeong, Jong Chul Park

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Neural cortical cells, isolated from prenatal rat cerebra, were grown on surface-modified poly(lactic-coglycolic acid, 65:35) (PLGA) films coated with poly-D-lysine (PDL) with either laminin (LN), fibronectin (FN) or collagen (CN). Immunocytochemistry showed that the isolated cells were highly immunopositive for both neurofilament and MAP-2 with well-organized neurites and somatodendritic localization. The presence of PDL with LN or FN on the PLGA films was essential for increased neural cell growth. Also, PLGA films coated with either PDL/LN or PDL/FN mixtures had higher neurite outgrowth and regular differentiation.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalBiotechnology Letters
Volume27
Issue number1
DOIs
Publication statusPublished - 2005 Jan 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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