Enhanced oral bioavailability of the hydrophobic chemopreventive agent (Sr13668) in beagle dogs

Aryamitra A. Banerjee, Hao Shen, Mathew Hautman, Jaseem Anwer, Seungpyo Hong, Izet M. Kapetanovic, Ying Liu, Alexander V. Lyubimov

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Potency and activity of SR13668 in cancer prevention have been proven in several in vitro and in vivo cancer models. However, the compound is highly hydrophobic and its limited oral bioavailability has hindered its clinical translation. In this study, we encapsulated SR13668 into polymeric nanoparticles to increase compound aqueous solubility and therefore bioavailability. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (100-200nm) encapsulating SR13668 with narrow size distribution and high drug loading were generated by a continuous and scalable process of flash nanoprecipitation integrated with spray dry. A single gavage dose of SR13668-PLGA nanoparticles at 2.8 mg/kg was administered in eight beagle dogs. Drug levels in animal whole blood and plasma were measured over 24 hours. Enhanced bioavailability of SR13668 using nanoparticles compared with formulations of Labrasol® and neat drug in 0.5% methylcellulose is reported. This is the first attempt to study pharmacokinetics of SR13668 in large animals with orally administrated nanoparticle suspension.

Original languageEnglish
Pages (from-to)464-469
Number of pages6
JournalCurrent Pharmaceutical Biotechnology
Volume14
Issue number4
DOIs
Publication statusPublished - 2013 Jun 14

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Biological Availability
Nanoparticles
Dogs
Pharmaceutical Preparations
Methylcellulose
Solubility
SR 13668
Neoplasms
Suspensions
Pharmacokinetics
polylactic acid-polyglycolic acid copolymer

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Pharmaceutical Science

Cite this

Banerjee, Aryamitra A. ; Shen, Hao ; Hautman, Mathew ; Anwer, Jaseem ; Hong, Seungpyo ; Kapetanovic, Izet M. ; Liu, Ying ; Lyubimov, Alexander V. / Enhanced oral bioavailability of the hydrophobic chemopreventive agent (Sr13668) in beagle dogs. In: Current Pharmaceutical Biotechnology. 2013 ; Vol. 14, No. 4. pp. 464-469.
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Banerjee, AA, Shen, H, Hautman, M, Anwer, J, Hong, S, Kapetanovic, IM, Liu, Y & Lyubimov, AV 2013, 'Enhanced oral bioavailability of the hydrophobic chemopreventive agent (Sr13668) in beagle dogs', Current Pharmaceutical Biotechnology, vol. 14, no. 4, pp. 464-469. https://doi.org/10.2174/1389201011314040012

Enhanced oral bioavailability of the hydrophobic chemopreventive agent (Sr13668) in beagle dogs. / Banerjee, Aryamitra A.; Shen, Hao; Hautman, Mathew; Anwer, Jaseem; Hong, Seungpyo; Kapetanovic, Izet M.; Liu, Ying; Lyubimov, Alexander V.

In: Current Pharmaceutical Biotechnology, Vol. 14, No. 4, 14.06.2013, p. 464-469.

Research output: Contribution to journalArticle

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AU - Hong, Seungpyo

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