Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO-NPs added to hfNSC culture during neurosphere formation substantially promote cell-to-cell and cell-to-matrix interactions in neurospheres. Accordingly, GO-NP-treated hfNSCs show enhanced self-renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis. (Figure presented.).
Bibliographical noteFunding Information:
This work was supported by National Research Foundation of Korea (NRF) grants (NRF-2015R1A2A1A15053771, NRF-2015M3A9B4071076, and NRF-2015R1A2A1A05001832). J.K. is a fellowship awardee of the Global Ph.D. Fellowship program (NRF-2013-Global Ph.D. Fellowship Program).
All Science Journal Classification (ASJC) codes
- Polymers and Plastics
- Materials Chemistry