Abstract
Objectives This work aimed to compare some pharmacological properties of red ginseng extract (RG) and fermented red ginseng extract (FRG). Methods Antinociceptive activity was analysed using the acetic acid-induced abdominal constriction response. Anti-inflammatory activity was evaluated using acetic acid-induced vascular permeability and carrageenan-induced inflammation in the air pouch, and analysed through the measurement of nitrite content in the lipopolysaccharide (LPS)-stimulated macrophage cells. Anti-angiogenic activity was determined using the chick chorioallantoic membrane assay. Key findings In-vivo anti-inflammatory activity of FRG was stronger than that of RG in two animal models, vascular permeability and air-pouch models. In the vascular permeability model, the doses of RG and FRG required for half-maximal inhibition (IC50) were 181 and 59 mg/kg, respectively. FRG exhibited significantly stronger antinociceptive activity than RG. In the acetic acid-induced abdominal constriction response, the IC50 values of RG and FRG were 153 and 27 mg/kg, respectively. Although both RG and FRG were able to suppress production of nitric oxide in the LPS-stimulated RAW264.7 macrophage cells, the suppressive activity of FRG appeared to be stronger than that of RG. However, RG and FRG showed similar anti-angiogenic activity. Conclusions FRG possesses enhanced anti-inflammatory and antinociceptive activity but similar anti-angiogenic activity than RG.
| Original language | English |
|---|---|
| Pages (from-to) | 756-762 |
| Number of pages | 7 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 64 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 May 1 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmaceutical Science
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Enhancement of anti-inflammatory and antinociceptive actions of red ginseng extract by fermentation. / Jung, Hyun Joo; Choi, Hojin; Lim, Hye Won; Shin, Daehyun; Kim, Hacksoo; Kwon, Bin; Lee, Jongeun; Park, Eun Hee; Lim, Chang Jin.
In: Journal of Pharmacy and Pharmacology, Vol. 64, No. 5, 01.05.2012, p. 756-762.Research output: Contribution to journal › Article
TY - JOUR
T1 - Enhancement of anti-inflammatory and antinociceptive actions of red ginseng extract by fermentation
AU - Jung, Hyun Joo
AU - Choi, Hojin
AU - Lim, Hye Won
AU - Shin, Daehyun
AU - Kim, Hacksoo
AU - Kwon, Bin
AU - Lee, Jongeun
AU - Park, Eun Hee
AU - Lim, Chang Jin
PY - 2012/5/1
Y1 - 2012/5/1
N2 - Objectives This work aimed to compare some pharmacological properties of red ginseng extract (RG) and fermented red ginseng extract (FRG). Methods Antinociceptive activity was analysed using the acetic acid-induced abdominal constriction response. Anti-inflammatory activity was evaluated using acetic acid-induced vascular permeability and carrageenan-induced inflammation in the air pouch, and analysed through the measurement of nitrite content in the lipopolysaccharide (LPS)-stimulated macrophage cells. Anti-angiogenic activity was determined using the chick chorioallantoic membrane assay. Key findings In-vivo anti-inflammatory activity of FRG was stronger than that of RG in two animal models, vascular permeability and air-pouch models. In the vascular permeability model, the doses of RG and FRG required for half-maximal inhibition (IC50) were 181 and 59 mg/kg, respectively. FRG exhibited significantly stronger antinociceptive activity than RG. In the acetic acid-induced abdominal constriction response, the IC50 values of RG and FRG were 153 and 27 mg/kg, respectively. Although both RG and FRG were able to suppress production of nitric oxide in the LPS-stimulated RAW264.7 macrophage cells, the suppressive activity of FRG appeared to be stronger than that of RG. However, RG and FRG showed similar anti-angiogenic activity. Conclusions FRG possesses enhanced anti-inflammatory and antinociceptive activity but similar anti-angiogenic activity than RG.
AB - Objectives This work aimed to compare some pharmacological properties of red ginseng extract (RG) and fermented red ginseng extract (FRG). Methods Antinociceptive activity was analysed using the acetic acid-induced abdominal constriction response. Anti-inflammatory activity was evaluated using acetic acid-induced vascular permeability and carrageenan-induced inflammation in the air pouch, and analysed through the measurement of nitrite content in the lipopolysaccharide (LPS)-stimulated macrophage cells. Anti-angiogenic activity was determined using the chick chorioallantoic membrane assay. Key findings In-vivo anti-inflammatory activity of FRG was stronger than that of RG in two animal models, vascular permeability and air-pouch models. In the vascular permeability model, the doses of RG and FRG required for half-maximal inhibition (IC50) were 181 and 59 mg/kg, respectively. FRG exhibited significantly stronger antinociceptive activity than RG. In the acetic acid-induced abdominal constriction response, the IC50 values of RG and FRG were 153 and 27 mg/kg, respectively. Although both RG and FRG were able to suppress production of nitric oxide in the LPS-stimulated RAW264.7 macrophage cells, the suppressive activity of FRG appeared to be stronger than that of RG. However, RG and FRG showed similar anti-angiogenic activity. Conclusions FRG possesses enhanced anti-inflammatory and antinociceptive activity but similar anti-angiogenic activity than RG.
UR - http://www.scopus.com/inward/record.url?scp=84862812499&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862812499&partnerID=8YFLogxK
U2 - 10.1111/j.2042-7158.2012.01460.x
DO - 10.1111/j.2042-7158.2012.01460.x
M3 - Article
C2 - 22471373
AN - SCOPUS:84862812499
VL - 64
SP - 756
EP - 762
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 5
ER -